Negative blood oxygenation level dependent homunculus and somatotopic information in primary motor cortex and supplementary motor area

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 45, 2012, Pages 18565-18570

  Zeharia, Noa ^a,b   Hertz, Uri ^a,b   Flash, Tamar ^c   Amedi, Amir ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Neural inhibition; Somatotopy

Indexed keywords

ARTICLE; BODY MOVEMENT; BOLD SIGNAL; CLINICAL ARTICLE; ELECTROMYOGRAPHY; EVENT RELATED POTENTIAL; FACE; FEMALE; HAND MOVEMENT; HEMODYNAMICS; HUMAN; LEG MOVEMENT; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; SUPPLEMENTARY MOTOR AREA; TOE; TONGUE; TRUNK; VASCULARIZATION;

FEMALE; HUMANS; LINEAR MODELS; MALE; MOTOR CORTEX; MOVEMENT; OXYGEN;

EID: 84868529282     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119125109     Document Type: Article

References (39)

1. Penfield W, Boldrey E (1937) Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain: A Journal of Neurology 60:389-443.
2. Meier JD, Aflalo TN, Kastner S, Graziano MSA (2008) Complex organization of human primary motor cortex: A high-resolution fMRI study. J Neurophysiol 100:1800-1812.
3. Schieber MH (2001) Constraints on somatotopic organization in the primary motor cortex. J Neurophysiol 86:2125-2143.
4. Chainay H, et al. (2004) Foot, face and hand representation in the human supplementary motor area. Neuroreport 15:765-769. (Pubitemid 38453454)
5. Chassagnon S, Minotti L, Kremer S, Hoffmann D, Kahane P (2008) Somatosensory, motor, and reaching/grasping responses to direct electrical stimulation of the human cingulate motor areas. J Neurosurg 109:593-604.
6. Hanakawa T, et al. (2001) Functional mapping of human medial frontal motor areas. The combined use of functional magnetic resonance imaging and cortical stimulation. Exp Brain Res 138:403-409. (Pubitemid 32467758)
7. Luppino G, Matelli M, Camarda RM, Gallese V, Rizzolatti G (1991) Multiple representations of body movements in mesial area 6 and the adjacent cingulate cortex: An intracortical microstimulation study in the macaque monkey. J Comp Neurol 311:463-482.
8. Engel SA (2012) The development and use of phase-encoded functional MRI designs. Neuroimage 62:1195-1200.
9. Engel SA, et al. (1994) fMRI of human visual cortex. Nature 369:525.
10. Sereno MI, Huang RS (2006) A human parietal face area contains aligned head-centered visual and tactile maps. Nat Neurosci 9:1337-1343. (Pubitemid 44454276)
11. Striem-Amit E, Hertz U, Amedi A (2011) Extensive cochleotopic mapping of human auditory cortical fields obtained with phase-encoding FMRI. PLoS One 6:e17832.
12. Tinazzi M, et al. (2005) Task-specific impairment of motor cortical excitation and inhibition in patients with writer's cramp. Neurosci Lett 378:55-58. (Pubitemid 40341941)
13. Sanger TD, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW Task Force on Childhood Motor Disorders (2003) Classification and definition of disorders causing hypertonia in childhood. Pediatrics 111:e89-e97.
14. Thelen E, Kelso J, Fogel A (1987) Self-organizing systems and infant motor development. Dev Rev 7:39-65.
15. Brown P, Day BL, Rothwell JC, Thompson PD, Marsden CD (1991) Intrahemispheric and interhemispheric spread of cerebral cortical myoclonic activity and its relevance to epilepsy. Brain 114:2333-2351.
16. Huntley GW, Jones EG (1991) Relationship of intrinsic connections to forelimb movement representations in monkey motor cortex: A correlative anatomic and physiological study. J Neurophysiol 66:390-413.
17. Woolsey CN, et al. (1952) Patterns of localization in precentral and "supplementary" motor areas and their relation to the concept of a premotor area. Res Publ Assoc Res Nerv Ment Dis 30:238-264.
18. Shmuel A, Augath M, Oeltermann A, Logothetis NK (2006) Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1. Nat Neurosci 9:569-577.
19. Shmuel A, et al. (2002) Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain. Neuron 36:1195-1210. (Pubitemid 36044518)
20. Ferbert A, et al. (1992) Interhemispheric inhibition of the human motor cortex. J Physiol 453:525-546.
21. Perez MA, Cohen LG (2008) Mechanisms underlying functional changes in the primary motor cortex ipsilateral to an active hand. J Neurosci 28:5631-5640.
22. Stefanovic B, Warnking JM, Pike GB (2004) Hemodynamic and metabolic responses to neuronal inhibition. Neuroimage 22:771-778. (Pubitemid 38759440)
23. Allison JD, Meador KJ, Loring DW, Figueroa RE, Wright JC (2000) Functional MRI cerebral activation and deactivation during finger movement. Neurology 54:135-142. (Pubitemid 30038751)
24. Nass R (1985) Mirror movement asymmetries in congenita1 hemiparesis. Neurology 35:1059.
25. Sehm B, Perez MA, Xu B, Hidler J, Cohen LG (2010) Functional neuroanatomy of mirroring during a unimanual force generation task. Cereb Cortex 20:34-45.
26. Orlov T, Makin TR, Zohary E (2010) Topographic representation of the human body in the occipitotemporal cortex. Neuron 68:586-600.
27. Engel SA, Glover GH, Wandell BA (1997) Retinotopic organization in human visual cortex and the spatial precision of functional MRI. Cereb Cortex 7:181-192. (Pubitemid 27120280)
28. Hertz U, Amedi A (2010) Disentangling unisensory and multisensory components in audiovisual integration using a novel multifrequency fMRI spectral analysis. Neuroimage 52:617-632.
29. Sereno MI, et al. (1995) Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging. Science 268:889-893.
30. Wandell BA, Winawer J (2011) Imaging retinotopic maps in the human brain. Vision Res 51:718-737.
31. Bressler D, Spotswood N, Whitney D (2007) Negative BOLD fMRI response in the visual cortex carries precise stimulus-specific information. PLoS One 2:e410.
32. Linke AC, Vicente-Grabovetsky A, Cusack R (2011) Stimulus-specific suppression preserves information in auditory short-term memory. Proc Natl Acad Sci USA 108: 12961-12966.
33. Kiernan JA (2009) Barr's the Human Nervous System: An Anatomical Viewpoint (Lippincott Williams & Wilkins, Philadelphia), pp 370-371.
34. Toma K, et al. (1999) Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: An event-related fMRI study. J Neurosci 19:3527-3534. (Pubitemid 29203132)
35. Pandya DN, Vignolo LA (1971) Intra- and interhemispheric projections of the precentral, premotor and arcuate areas in the rhesus monkey. Brain Res 26:217-233.
36. Ni Z, et al. (2009) Two phases of interhemispheric inhibition between motor related cortical areas and the primary motor cortex in human. Cereb Cortex 19:1654-1665.
37. Byblow WD, et al. (2007) Functional connectivity between secondary and primary motor areas underlying hand-foot coordination. J Neurophysiol 98:414-422. (Pubitemid 47084831)
38. Forman SD, et al. (1995) Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): Use of a cluster-size threshold. Magn Reson Med 33:636-647.
39. Penfield W, Rasmussen T (1950) The Cerebral Cortex of Man: A Clinical Study of Localization of Function (Macmillian, New York), Available at http://www.cengage.com/permissions.