LC-ESI-MS/MS analysis of testosterone at sub-picogram levels using a novel derivatization reagent

Analytical Chemistry

Volumn 84, Issue 21, 2012, Pages 9310-9317

  Star Weinstock, Michal ^a   Williamson, Brian L ^a   Dey, Subhakar ^a   Pillai, Sasi ^a   Purkayastha, Subhasish ^a  

^a MDS SCIEX   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL METHOD; DERIVATIZATION METHOD; DERIVATIZATION REAGENT; DERIVATIZATIONS; DRIED BLOOD SPOTS; DYNAMIC RANGE; ESI-MS/MS; HIGH SENSITIVITY; HUMAN SERUM; IONIZATION EFFICIENCY; LC-ESI-MS/MS; LC-MS/MS; LOWER LIMIT OF QUANTITATIONS; NEUTRAL STEROIDS; NONDERIVATIZATION; SAMPLE PREPARATION; SERUM SAMPLES; TRACE CONCENTRATIONS; WORK-FLOWS;

ALDEHYDES; BLOOD; HORMONES; KETONES; ORGANIC COMPOUNDS;

TRACE ANALYSIS;

AMINE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; TESTOSTERONE;

ADOLESCENT; ADULT; ANALYSIS; ARTICLE; BLOOD; CHEMISTRY; CHILD; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MALE; METHODOLOGY; MIDDLE AGED; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

ADOLESCENT; ADULT; AMINES; ANALYTIC SAMPLE PREPARATION METHODS; CHILD; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FEMALE; HUMANS; INDICATORS AND REAGENTS; LIMIT OF DETECTION; MALE; MIDDLE AGED; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TESTOSTERONE; YOUNG ADULT;

EID: 84868522843     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac302036r     Document Type: Article

References (27)

1. Mazer, N. A. Int. J. Fertil. Women's Med. 2002, 47, 77-86
2. Migeon, C. J.; Berkovitz, G. D.; Brown, T. R. Sexual differentiation and ambiguity. In The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence; Kappy, M. S.; Blizzard, R. M.; Migeon, C. J., Eds.; Charles C. Thomas: Springfield, IL, 1994; pp 573-715.
3. Kulin, H. E.; Finkelstein, J. W.; D'Arcangelo, M. R.; Susman, E. J.; Chinchilli, V.; Kunselman, S. J. J. Pediatr. Endocrinol. Metab. 1997, 10, 395-400
4. Rosner, W.; Auchus, R. J.; Aziz, R.; Sluss, P. M.; Hershel, R. J. Clin. Endocrinol. Metab. 2010, 92, 405-413
5. Yeap, B. B.; Almeida, O. P.; Hyde, Z.; Norman, P. E.; Chubb, S. A. P.; Jamrosik, K. Eur. J. Endocrinol. 2007, 156, 585-594
6. Chen, Y.; Yazdanpanah, M.; Wang, Y. W.; Hoffman, B. R.; Diamandis, E. P.; Wong, P. Y. Clin. Biochem. 2012, 43, 490-496
7. Rauh, M. Mol. Cell. Endocrinol. 2009, 301, 272-281
8. Moal, V.; Mathieu, E.; Reynier, P.; Malthiéry, Y.; Gallois, Y. Clin. Chim. Acta 2007, 386, 12-19
9. Cawood, M. L.; Field, H. P.; Ford, C. G.; Gillingwater, S.; Kickman, A.; Cowan, D.; Barth, J. H. Clin. Chem. 2005, 51, 1472-1479
10. Demers, M. L. Steroids 2008, 73, 1333-1338
11. Shiraishi, S.; Lee, P. W. N; Leung, A.; Goh, V. H. H.; Swerdloff, R. S.; Wang, C. Clin. Chem. 2008, 54, 1855-1863
12. Kushnir, M. M; Rockwood, A. L.; Roberts, W. L.; Yue, B.; Bergquist, J.; Meikle, A. W. Clin. Biochem. 2011, 44, 77-88
13. Kushnir, M. M.; Rockwood, A. L.; Roberts, W. L.; Pattison, E. G.; Bunker, A. M.; Fitzgerald, R. L.; Meikle, A. W. Clin. Chem. 2006, 52, 120-128
14. Borrey, D.; Moerman, E.; Cockx, A.; Engelrelst, V.; Langlois, M. R. Clin. Chim. Acta 2007, 382, 134-137
15. Bui, H. N.; Struys, E. A.; Martens, F.; de Ronde, W.; Thienpont, L. M.; Kenemans, P.; O Verhoeven, M.; Jakobs, C.; Dijstelbloem, H. M.; Blankenstein, M. A. Ann. Clin. Biochem. 2010, 47, 248-252
16. Niwa, M.; Watanabe, N.; Ochiai, H.; Yamashita, K. J. Chromatogr., B 2005, 824, 258-266
17. Higashi, T.; Yamauchi, A.; Shimada, K. J. Chromatogr., B 2005, 825, 214-222
18. Griffiths, W. J; Wang, Y.; Karu, K.; Samuel, E.; McDonnell, S.; Hornshaw, M.; Shackleton, C. Clin. Chem. 2008, 54, 81317-81324
19. Kirk, J. M.; Tarbin, J.; Keely, B. J. Rapid Commun. Mass Spectrom. 2006, 20, 1247-1252
20. Johnson, D. Rapid Commun. Mass Spectrom. 2005, 19, 193-200
21. Dirksen, A.; Dawson, P. E. Bioconjugate Chem. 2008, 19, 2543-2548
22. Kushnir, M. M.; Blamires, T.; Rockwood, A. L.; Roberts, W.; Yue, B.; Erdogan, E.; Bunker, A. M.; Meikle, A. W. Clin. Chem. 2010, 56, 1138-1147
23. Kalhorn, T. F.; Page, W. N.; Howald, W. N.; Mostaghel, E. A.; Nelsom, P. S. Rapid Commun. Mass Spectrom. 2007, 21, 3200-3206
24. Li, W.; Cohen, L. H. Anal. Chem. 2003, 75, 5854-5859
25. Annesley, T. M. Clin. Chem. 2003, 49, 1041-1044
26. Higashi, T.; Tadashi, N.; Noriko, H.; Kazutake, S. Chem. Pharm. Bull. 2007, 55, 662-665
27. Swerdloff, R. S.; Wang, C. Clin. Chem. 2008, 54, 458-460