Transplantation in the obese: Separating myth from reality

Nephrology Dialysis Transplantation

Volumn 27, Issue 10, 2012, Pages 3732-3735

  Khwaja, Arif ^a   El Nahas, Meguid ^a  

^a NORTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

kidney; obesity; outcomes; sarcopenia; transplantation

Indexed keywords

BODY MASS; CHRONIC KIDNEY DISEASE; COMORBIDITY; DELAYED GRAFT FUNCTION; DIABETES MELLITUS; DISEASE EXACERBATION; GRAFT SURVIVAL; HIGH RISK PATIENT; HUMAN; KIDNEY DONOR; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MUSCLE ATROPHY; OBESITY; PATIENT SAFETY; PATIENT SELECTION; PRIORITY JOURNAL; PROGNOSIS; RENAL REPLACEMENT THERAPY; REVIEW; SURGICAL INFECTION; SURGICAL RISK; TREATMENT OUTCOME; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WEIGHT REDUCTION;

BODY MASS INDEX; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; OBESITY; RENAL REPLACEMENT THERAPY; SARCOPENIA; TISSUE DONORS; TREATMENT OUTCOME; WEIGHT REDUCTION PROGRAMS;

EID: 84868515846     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfs406     Document Type: Review

References (41)

1. Dudley C, Harden P. Renal Association Clinical Practice Guideline on the assessment of the potential kidney transplant recipient. Nephron Clin Pract 2011; 118 (Suppl 1): c209-c224
2. Kalble T, Lucan M, Nicita G et al. EAU guidelines on renal transplantation. Eur Urol 2005; 47: 156-166
3. MacLaughlin HL, Cook SA, Kariyawasam D et al. Nonrandomized trial of weight loss with orlistat, nutrition education, diet, and exercise in obese patients with CKD: 2-year follow-up. Am J Kidney Dis 2010; 55: 69-76
4. Zrim S, Furlong T, Grace BS et al. Body mass index and post-operative complications in kidney transplant recipients. Nephrology (Carlton) 2012; 17: 582-587
5. Kalantar-Zadeh K, Block G, Humphreys MH et al. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 2003; 63: 793-808
6. Kalantar-Zadeh K, Streja E, Kovesdy CP et al. The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis. Mayo Clin Proc 2010; 85: 991-1001
7. Salahudeen AK. Obesity and survival on dialysis. Am J Kidney Dis 2003; 41: 925-932
8. Wong JS, Port FK, Hulbert-Shearon TE et al. Survival advantage in Asian American end-stage renal disease patients. Kidney Int 1999; 55: 2515-2523
9. Leavey SF, McCullough K, Hecking E et al. Body mass index and mortality in 'healthier' as compared with 'sicker' haemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 2001; 16: 2386-2394
10. Zoccali C, Testa A, Spoto B et al. Mendelian randomization: a new approach to studying epidemiology in ESRD. Am J Kidney Dis 2006; 47: 332-341
11. Kalantar-Zadeh K, Streja E, Molnar MZ et al. Mortality prediction by surrogates of body composition: an examination of the obesity paradox in hemodialysis patients using composite ranking score analysis. Am J Epidemiol 2012; 175: 793-803
12. Noori N, Kopple JD, Kovesdy CP et al. Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients. Clin J Am Soc Nephrol 2010; 5: 2258-2268
13. Molnar MZ, Streja E, Kovesdy CP et al. Associations of body mass index and weight loss with mortality in transplant-waitlisted maintenance hemodialysis patients. Am J Transplant 2011; 11: 725-736
14. Schold JD, Srinivas TR, Guerra G et al. A 'weight-listing' paradox for candidates of renal transplantation? Am J Transplant 2007; 7: 550-559
15. Molnar MZ, Kovesdy CP, Bunnapradist S et al. Associations of pretransplant serum albumin with post-transplant outcomes in kidney transplant recipients. Am J Transplant 2011; 11: 1006-1015
16. MacLaughlin HL, Hall WL, Patel AG et al. Laparoscopic sleeve gastrectomy is a novel and effective treatment for obesity in patients with chronic kidney disease. Obes Surg 2012; 22: 119-123
17. Turgeon NA, Perez S, Mondestin M et al. The impact of renal function on outcomes of bariatric surgery. J Am Soc Nephrol 2012; 23: 885-894
18. Modanlou KA, Muthyala U, Xiao H et al. Bariatric surgery among kidney transplant candidates and recipients: analysis of the United States renal data system and literature review. Transplantation 2009; 87: 1167-1173
19. Howard RJ, Thai VB, Patton PR et al. Obese kidney transplant recipients have good outcomes. Transplant Proc 2001; 33: 3420-3421
20. Furriel F, Parada B, Campos L et al. Pretransplantation overweight and obesity: does it really affect kidney transplantation outcomes? Transplant Proc 2011; 43: 95-99
21. Johnson DW, Isbel NM, Brown AM et al. The effect of obesity on renal transplant outcomes. Transplantation 2002; 74: 675-681
22. Weissenbacher A, Jara M, Ulmer H et al. Recipient and donor body mass index as important risk factors for delayed kidney graft function. Transplantation 2012; 93: 524-529
23. Doshi MD, Garg N, Reese PP et al. Recipient risk factors associated with delayed graft function: a paired kidney analysis. Transplantation 2011; 91: 666-671
24. Molnar MZ, Kovesdy CP, Mucsi I et al. Higher recipient body mass index is associated with post-transplant delayed kidney graft function. Kidney Int 2011; 80: 218-224
25. Meier-Kriesche HU, Arndorfer JA, Kaplan B. The impact of body mass index on renal transplant outcomes: a significant independent risk factor for graft failure and patient death. Transplantation 2002; 73: 70-74
26. Chang SH, Coates PT, McDonald SP. Effects of body mass index at transplant on outcomes of kidney transplantation. Transplantation 2007; 84: 981-987
27. Streja E, Molnar MZ, Kovesdy CP et al. Associations of pretransplant weight and muscle mass with mortality in renal transplant recipients. Clin J Am Soc Nephrol 2011; 6: 1463-1473
28. Gore JL, Pham PT, Danovitch GM et al. Obesity and outcome following renal transplantation. Am J Transplant 2006; 6: 357-363
29. Hoogeveen EK, Aalten J, Rothman KJ et al. Effect of obesity on the outcome of kidney transplantation: a 20-year follow-up. Transplantation 2011; 91: 869-874
30. Bayer ND, Cochetti PT, Anil Kumar MS et al. Association of metabolic syndrome with development of new-onset diabetes after transplantation. Transplantation 2010; 90: 861-866
31. Marrero D, Hernandez D, Tamajon LP et al. Pre-transplant weight but not weight gain is associated with new-onset diabetes after transplantation: a multi-centre cohort Spanish study. NDT Plus 2010; 3: ii15-ii20
32. Yusuf S, Hawken S, Ounpuu S et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364: 937-952
33. Postorino M, Marino C, Tripepi G et al. Abdominal obesity and allcause and cardiovascular mortality in end-stage renal disease. J Am Coll Cardiol 2009; 53: 1265-1272
34. Kovesdy CP, Czira ME, Rudas A et al. Body mass index, waist circumference and mortality in kidney transplant recipients. Am J Transplant 2010; 10: 2644-2651
35. Glanton CW, Kao TC, Cruess D et al. Impact of renal transplantation on survival in end-stage renal disease patients with elevated body mass index. Kidney Int 2003; 63: 647-653
36. Segev DL, Simpkins CE, Thompson RE et al. Obesity impacts access to kidney transplantation. J Am Soc Nephrol 2008; 19: 349-355
37. Nogueira JM, Weir MR, Jacobs S et al. A study of renal outcomes in obese living kidney donors. Transplantation 2010; 90: 993-999
38. Nogueira JM, Weir MR, Jacobs S et al. A study of renal outcomes in African American living kidney donors. Transplantation 2009; 88: 1371-1376
39. O'Brien B, Mastoridis S, Sabharwal A et al. Expanding the donor pool: living donor nephrectomy in the elderly and the overweight. Transplantation 2012; 93: 1158-1165
40. Tavakol MM, Vincenti FG, Assadi H et al. Long-term renal function and cardiovascular disease risk in obese kidney donors. Clin J Am Soc Nephrol 2009; 4: 1230-1238
41. Ortiz J, Gregg A, Wen X et al. Impact of donor obesity and donation after cardiac death on outcomes after kidney transplantation. Clin Transplant 2012; 26: E284-E292.