HIV incidence in young girls in KwaZulu-Natal, South Africa-public health imperative for their inclusion in HIV biomedical intervention trials

AIDS and Behavior

Volumn 16, Issue 7, 2012, Pages 1870-1876

  Karim, Quarraisha Abdool ^a,b   Kharsany, Ayesha B M ^a   Frohlich, Janet A ^a   Werner, Lise ^a   Mlotshwa, Mukelisiwe ^a   Madlala, Bernadette T ^a   Karim, Salim S Abdool ^a,b  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b Mailman School of Public Health   (United States)

Author keywords

Biomedical HIV prevention research; South Africa; Young girls

Indexed keywords

ADOLESCENT; ARTICLE; CLINICAL TRIAL (TOPIC); FEASIBILITY STUDY; FEMALE; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; INCIDENCE; MEDICAL RESEARCH; PATIENT SELECTION; PREGNANCY; PROPORTIONAL HAZARDS MODEL; PUBLIC HEALTH; SEXUAL BEHAVIOR; SOUTH AFRICA;

ADOLESCENT; BIOMEDICAL RESEARCH; CLINICAL TRIALS AS TOPIC; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HIV SEROPREVALENCE; HUMANS; INCIDENCE; PATIENT SELECTION; PREGNANCY; PROPORTIONAL HAZARDS MODELS; PUBLIC HEALTH; SEXUAL BEHAVIOR; SOUTH AFRICA;

EID: 84868460128     PISSN: 10907165     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10461-012-0209-y     Document Type: Article

References (30)

1. World Health Organisation and Joint United Nations Programme on HIV/AIDS. GLOBAL HIV/AIDS RESPONSE - epidemic update and health sector progress towards Universal Access. http://whqlibdoc.who.int/publications/2011/9789241502986-eng. pdf2011
2. Gouws E, Stanecki KA, Lyerla R, Ghys PD. The epidemiology of HIV infection among young people aged 15-24 years in southern Africa. AIDS. 2008;22(Suppl 4):S5-16
3. Gouws E. HIV incidence rates in South Africa. In: Abdool Karim S. S, Abdool Karim Q, editors. HIV/AIDS in South Africa. New York: Cambridge University Press; 2nd Edition. 2010. pp. 74-84
4. Rehle T, Shisana O, Pillay V, Zuma K, Puren A, Parker W. National HIV incidence measures-new insights into the South African epidemic. S Afr Med J. 2007;97:194-9
5. National Department of Health. The 2010 National Antenatal Sentinel HIV and Syphilis Prevalence Survey in South Africa. 2011
6. Shisana O, Rehle T, Simbayi LC, Zuma K, Jooste S, Pillay-van- Wyk V, et al. South African national HIV prevalence, incidence, behaviour and communication survey 2008: A turning tide among teenagers?. Cape Town: HSRC Press; 2009
7. Collins C, Coates TJ, Curran J. Moving beyond the alphabet soup of HIV prevention. AIDS. 2008;22(Suppl 2):S5-8
8. Johnson BT, Scott-Sheldon LA, Huedo-Medina TB, Carey MP. Interventions to reduce sexual risk for human immunodeficiency virus in adolescents: a meta-analysis of trials, 1985-2008. Arch Pediatr Adolesc Med. 2011;165:77-84
9. Abdool Karim Q, Kharsany AB, Frohlich JA, Werner L, Mashego M, Mlotshwa M, et al. Stabilizing HIV prevalence masks high HIV incidence rates amongst rural and urban women in KwaZulu-Natal, South Africa. Int J Epidemiol. 2011;40:922-30
10. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493-505
11. Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363:2587-99
12. Centre for Disease Control Prevention. The CDC Botswana TDF- 2 study: CDC trial and another major study find PrEP can reduce risk of HIV infection among heterosexuals. July 13, 2011. http://www.cdc.gov/nchhstp/newsroom/ PrEPHeterosexuals.html. Accessed 20 Jan 2012
13. Science News. Partners PrEP study: pivotal study in Africa finds that HIV medications prevent HIV infection. July 13, 2011. http://www.sciencedaily.com/ releases/2011/07/ 110713092149.htm. Accessed 20 Jan 2012
14. Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168-74
15. Early end for FEM-PrEP HIV prevention trial. AIDS Patient Care STDS 2011,25:383
16. National Institute of Allergy and Infectious Diseases (NIAID). Clinical trial of antiretroviral-based HIV prevention strategies for women now under way. Sept. 16, 2009 http://www.niaid.nih.gov/ news/newsreleases/2009/pages/voice. aspx. Accessed 20 Jan 2012
17. Van Damme L, Corneli A, Ahmed K, Agot K, Lombaard J, Kapiga S, Grant R, Kashuba A, Crucitti T, Taylor D, and FEMPrEP Study Group. The FEM-PrEP Trial of Emtricitabine/ Tenofovir Disoproxil Fumarate (Truvada) among African Women. 19th Conference on Retroviruses and Opportunistic Infections March 5-8, 2012, Seattle, Washington:Abstract Number 32LB
18. Mayer KH, Maslankowski LA, Gai F, El-Sadr WM, Justman J, Kwiecien A, et al. Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women. AIDS. 2006;20:543-51
19. DiClemente RJ, Ruiz MS, Sales JM. Barriers to adolescents' participation in HIV biomedical prevention research. J Acquir Immune Defic Syndr. 2010;54(Suppl 1):S12-7
20. Singh JA, Abdool Karim SS, Abdool Karim Q, Mlisana K, Williamson C, Gray C, et al. Enrolling adolescents in research on HIV and other sensitive issues: lessons from South Africa. PLoS Med. 2006;3:e180
21. MacQueen KM, Karim QA. Practice brief: adolescents and HIV clinical trials: ethics, culture, and context. J Assoc Nurses AIDS Care. 2007;18:78-82
22. Nelson RM, Lewis LL, Struble K, Wood SF. Ethical and regulatory considerations for the inclusion of adolescents in HIV biomedical prevention research. J Acquir Immune Defic Syndr. 2010;54(Suppl 1):S18-24
23. Strode A, Slack C, Essack Z. Child consent in South African law: implications for researchers, service providers and policy-makers. S Afr Med J. 2011;101:604-6
24. Strode A, Slack C, Mushariwa M. HIV vaccine research-South Africa's ethical-legal framework and its ability to promote the welfare of trial participants. S Afr Med J. 2005;95:598-601
25. Slack C, Strode A, Fleischer T, Gray G, Ranchod C. Enrolling adolescents in HIV vaccine trials: reflections on legal complexities from South Africa. BMC Med Ethics. 2007;8:5
26. Ethical issues in the NIMH Collaborative HIV/STD Prevention Trial. AIDS 2007,21 Suppl 2: S69-80
27. Rennie. S, Sugarman. J, and the HPTN Ethics working group. HIV prevention trials network ethics guidance for research. 2009, Available at: http://www.hptn.org/web%20documents/EWG/ HPTNEthicsGuidance020310.pdf. Accessed 2 May 2011
28. South Africa department of social development. Commencement of certain sections of the Children's Act, June 29 2007. Available at: http://www.info.gov. za/speeches/2007/07062915151003.htm. Accessed 2 May 2011
29. Strode A, Slack C, Essack Z. Child consent in South African law: implications for researchers, service providers and policy-makers. S Afr Med J. 2010;100:247-9
30. Mystakidou K, Panagiotou I, Katsaragakis S, Tsilika E, Parpa E. Ethical and practical challenges in implementing informed consent in HIV/AIDS clinical trials in developing or resource-limited countries. SAHARA J. 2009;6:46-57