The expression of high mobility group box 1 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma

Pathology and Oncology Research

Volumn 18, Issue 4, 2012, Pages 1021-1027

  Chuangui, Chen ^a   Peng, Tang ^a   Zhentao, Yu ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Esophageal squamous cell carcinoma (ESCC); High mobility group box 1 (HMGB1); Lymphangiogenesis; Vascular endothelial growth factor C (VEGF C)

Indexed keywords

CARRIER PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR 1; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN C;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CARCINOGENESIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS RESECTION; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LYMPH NODE METASTASIS; LYMPHATIC PARAMETERS; MAJOR CLINICAL STUDY; MALE; MICRO LYMPHATIC VESSEL DENSITY; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL TIME; TUMOR DIFFERENTIATION; WESTERN BLOTTING;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; ESOPHAGEAL NEOPLASMS; FEMALE; HMGB1 PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; RNA, SMALL INTERFERING; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VESICULAR TRANSPORT PROTEINS;

EID: 84868457926     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-012-9539-3     Document Type: Article

References (18)

1. Duff SE, Li C, Jeziorska M, Kumar S, Saunders MP, Sherlock D, O'Dwyer ST, Jayson GC (2003) Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. Br J Cancer 89:426-30
2. Aurello P, Rossi Del Monte S, D'Angelo F, Cicchini C, Ciardi A, Bellagamba R, Ravaioli M, Ramacciato G (2009) Vascular endothelial growth factor C and microvessel density in gastric carcinoma: correlation with clinicopathological factors. Our experience and review of the literature. Oncol Res 17:405-11
3. Shimoda H, Takahashi Y, Kajiwara T, Kato S (2003) Demonstration of the rat lymphatic vessels using immunohistochemistry and in situ hybridization for 5'- nucleotidase. Biomed Res 24:51-7
4. Liu P, Chen W, Zhu H, Liu B, Song S, Shen W, Wang F, Tucker S, Zhong B, Wang D (2009) Expression of VEGF-C correlates with a poor prognosis based on analysis of prognostic factors in 73 patients with esophageal squamous cell carcinomas. Jpn J Clin Oncol 39:644-50
5. Czura CJ, Wang H, Tracey KJ (2001) Dual roles for HMGB1: DNA binding and cytokine. J Endotoxin Res 7:315-21
6. Yao X, Zhao G, Yang H, Hong X, Bie L, Liu G (2010) Overexpression of high-mobility group box 1 correlates with tumor progression and poor prognosis in human colorectal carcinoma. J Cancer Res Clin Oncol 136:677-84
7. Palumbo R, Sampaolesi M, De Marchis F, Tonlorenzi R, Colombetti S, Mondino A, Cossu G, Bianchi ME (2004) Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. J Cell Biol 164:441-49
8. Gnanasekar M, Thirugnanam S, Ramaswamy K (2009) Short hairpin RNA (shRNA) constructs targeting high mobility group box-1 (HMGB1) expression leads to inhibition of prostate cancer cell survival and apoptosis. Int J Oncol 34:425-431
9. Tang D, Kang R, Zeh HJ 3rd, Lotze MT (2010) High-mobility group box 1 and cancer. Biochim Biophys Acta 1799:131-40
10. Kusume A, Sasahira T, Luo Y, Isobe M, Nakagawa N, Tatsumoto N, Fujii K, Ohmori H, Kuniyasu H (2009) Suppression of dendritic cells by HMGB1 is associated with lymph node metastasis of human colon cancer. Pathobiology 76:155-62
11. Moriwaka Y, Luo Y, Ohmori H, Fujii K, Tatsumoto N, Sasahira T, Kuniyasu H (2010) HMGB1 attenuates anti-metastatic defense of the lymph nodes in colorectal cancer. Pathobiology 77:17-23
12. Kang HJ, Lee H, Choi HJ, Youn JH, Shin JS, Ahn YH, Yoo JS, Paik YK, Kim H (2009) Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers. Lab Invest 89:948-59
13. Schlueter C, Weber H, Meyer B, Rogalla P, Roser K, Hauke S, Bullerdiek J (2005) Angiogenetic signaling through hypoxia HMGB1: an angiogenetic switch molecule. Am J Path 166:1259-63
14. Weidner N, Semple JP, Welch WR, Folkman J (1991) Tumor angiogenesis and metastasis -correlation in invasive breast carcinoma. N Engl J Med 324:1-8
15. Chen C, Sun J, Liu G, Chen J (2009) Effect of small interference RNA targeting HIF-1α mediated by rAAV combined L-ascorbate on pancreatic tumors in athymic mice. Pathol Oncol Res 15:109-14
16. Tuomela J, Valta M, Seppanen J, Tarkkonen K, Vaananen HK, Harkonen P (2009) Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors. BMC Cancer 9:362
17. Zeh HJ 3rd, Lotze MT (2005) Addicted to death: invasive cancer and the immune response to unscheduled cell death. J Immunother 28:1-9
18. Ito N, DeMarco RA, Mailliard RB, Han J, Rabinowich H, Kalinski P, Stolz DB, Zeh HJ 3rd, Lotze MT (2007) Cytolytic cells induce HMGB1 release from melanoma cell lines. J Leukoc Biol 81:75-83