Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging

British Journal of Clinical Pharmacology

Volumn 74, Issue 6, 2012, Pages 1013-1022

  Cao, Ying J ^a   Caffo, Brian S ^b   Fuchs, Edward J ^a   Lee, Linda A ^a   Du, Yong ^c   Li, Liye ^a   Bakshi, Rahul P ^a   Macura, Katarzyna ^c   Khan, Wasif A ^a   Wahl, Richard L ^c   Grohskopf, Lisa A ^d   Hendrix, Craig W ^a  

^a Division of Clinical Pharmacology   (United States)

^b Department of Biostatistics ^*  (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Gastrointestinal distribution; HIV microbicide; HIV prevention; Pharmacokinetics; Rectal dosing

Indexed keywords

GADOLINIUM; INDIUM 111; MICROBICIDE; TECHNETIUM 99M;

ADULT; AGED; ARTICLE; COLON; COMPUTER ASSISTED TOMOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SEMINAL PLASMA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPERM;

ADMINISTRATION, RECTAL; ADULT; ANTI-INFECTIVE AGENTS; CELLULOSE; COLON; GADOLINIUM; GADOLINIUM DTPA; GLYCEROL; HIV INFECTIONS; HOMOSEXUALITY, MALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MODELS, THEORETICAL; PENTETIC ACID; PHOSPHATES; PROPYLENE GLYCOLS; SEMEN; SIGMOIDOSCOPY; TECHNETIUM TC 99M SULFUR COLLOID; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84868450739     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04267.x     Document Type: Article

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