Recurrent left atrial myxomas in Carney complex: A genetic cause of multiple strokes that can be prevented

Journal of Stroke and Cerebrovascular Diseases

Volumn 21, Issue 8, 2012, Pages 914.e1-914.e8

  Briassoulis, George ^a   Kuburovic, Vladimir ^b   Xekouki, Paraskevi ^a   Patronas, Nicholas ^c   Keil, Meg F ^a   Lyssikatos, Charalampos ^a   Stajevic, Mila ^b   Kovacevic, Gordana ^b   Stratakis, Constantine A ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b Mother and Child Health Care Institute of Serbia Dr Vukan Cupic   (Serbia)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Carney complex; embolic; myxomas; regulatory subunit of the protein kinase gene; stroke

Indexed keywords

EID: 84868384605     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2012.01.006     Document Type: Article

References (17)

1. J.A. Carney, L.S. Hruska, and G.D. Beauchamp Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine over activity Mayo Clin Proc 61 1986 165 172
2. L.S. Kirschner, J.A. Carney, and S.D. Pack Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex Nat Genet 26 2000 89 92
3. A. Horvath, J. Bertherat, and L. Groussin Mutations and polymorphisms in the gene encoding regulatory subunit type 1-alpha of protein kinase A (PRKAR1A): An update Hum Mutat 31 2010 369 379
4. S.W. MacGowan, P. Sidhu, and T. Aherne Atrial myxoma: National incidence, diagnosis and surgical management Ir J Med Sci 162 1993 223 226
5. S. Turhan, C. Tulunay, and T. Altin Second recurrence of familial cardiac myxomas in atypical locations Can J Cardiol 24 2008 715 716
6. M. Al-Mateen, M. Hood, and D. Trippel Cerebral embolism from atrial myxoma in pediatric patients Pediatrics 112 2003 162 167
7. C.A. Stratakis, L.S. Kirschner, and J.A. Carney Clinical and molecular features of the Carney complex: Diagnostic criteria and recommendations for patient evaluation J Clin Endocrinol Metab 86 2001 4041 4046
8. R.G. Zahedi, D.S. Wald, and S. Ohri Carney complex Ann Thorac Surg 82 2006 320 322
9. A. Vandersteen, J. Turnbull, and W. Jan Cutaneous signs are important in the diagnosis of the rare neoplasia syndrome Carney complex Eur J Pediatr 168 2009 1401 1404
10. Q. Li, H. Shang, and D. Zhou Repeated embolism and multiple aneurysms: Central nervous system manifestations of cardiac myxoma Eur J Neurol 15 2008 e112 e113
11. K.S. Ryou, S.H. Lee, and S.H. Park Multiple fusiform myxomatous cerebral aneurysms in a patient with Carney complex J Neurosurg 109 2008 318 320
12. W.C. Jean, S.M. Walski-Easton, and E.S. Nussbaum Multiple intracranial aneurysms as delayed complications of an atrial myxoma: Case report Neurosurgery 49 2001 200 202
13. K. Reynen Cardiac myxomas N Engl J Med 333 1995 1610 1617
14. C.A. Stratakis, J.A. Carney, and J.P. Lin Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2 J Clin Invest 97 1996 699 705
15. L. Pinede, P. Duhaut, and R. Loire Clinical presentation of left atrial cardiac myxoma. A series of 112 consecutive cases Medicine (Baltimore) 80 2001 159 172
16. E. Ruttmann, J. Willeit, and H. Ulmer Neurological outcome of septic cardioembolic stroke after infective endocarditis Stroke 37 2006 2094 2099
17. G. Mantovani, S. Bondioni, and S. Corbetta Analysis of GNAS1 and PRKAR1A gene mutations in human cardiac myxomas not associated with multiple endocrine disorders J Endocrinol Invest 32 2009 501 504