A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus

mBio

Volumn 3, Issue 5, 2012, Pages

  Alter, Harvey J ^a   Mikovits, Judy A ^b   Switzer, William M ^c   Ruscetti, Francis W ^d   Lo, Shyh Ching ^e   Klimas, Nancy ^f,g   Komaroff, Anthony L ^h   Montoya, Jose G ⁱ   Bateman, Lucinda ^j   Levine, Susan ^k   Peterson, Daniel ^l   Levin, Bruce ^m   Hanson, Maureen R ⁿ   Genfi, Afia ^m   Bhat, Meera ^m   Zheng, Haoqiang ^c   Wang, Richard ^a   Li, Bingjie ^e   Hung, Guo Chiuan ^e   Lee, Li Ling ⁿ   Sameroff, Stephen ^m   Heneine, Walid ^c   Coffin, John ^o   Hornig, Mady ^m   Lipkin, W Ian ^m   more..

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Mikovits Consulting   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^e CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^f NOVA SOUTHEASTERN UNIVERSITY   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ STANFORD UNIVERSITY   (United States)

^j Fatigue Consultation Clinic   (United States)

^k Levine Clinic   (United States)

^l Simmaron Research Institute   (United States)

^m Och Spine at New York Presbyterian Hospitals   (United States)

ⁿ Department of Obstetrics Gynecology   (United States)

^o TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84868384160     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00266-12     Document Type: Article

References (39)

1. Jason LA, Benton MC, Valentine L, Johnson A, Torres-Harding S. 2008. The economic impact of ME/CFS: individual and societal costs. Dyn. Med. 7:6.
2. Holmes GP, et al. 1987. A cluster of patients with a chronic mononucleosis-like syndrome. Is Epstein-Barr virus the cause? JAMA 257:2297-2302.
3. Buchwald D, et al. 1992. A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Ann. Intern. Med. 116:103-113.
4. Bell KM, Cookfair D, Bell DS, Reese P, Cooper L. 1991. Risk factors associated with chronic fatigue syndrome in a cluster of pediatric cases. Rev. Infect. Dis. 13(Suppl. 1):S32-S38.
5. Levine PH, Snow PG, Ranum BA, Paul C, Holmes MJ. 1997. Epidemic neuromyasthenia and chronic fatigue syndrome in west Otago, New Zealand. A 10-year follow-up. Arch. Intern. Med. 157:750-754.
6. Komaroff AL, Buchwald DS. 1998. Chronic fatigue syndrome: an update. Annu. Rev. Med. 49:1-13.
7. Nakaya T, et al. 1996. Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome. FEBS Lett. 378:145-149.
8. Nasralla M, Haier J, Nicolson GL. 1999. Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome. Eur. J. Clin. Microbiol. Infect. Dis. 18:859-865.
9. Vojdani A, et al. 1998. Detection of Mycoplasma genus and Mycoplasma fermentans by PCR in patients with chronic fatigue syndrome. FEMS Immunol. Med. Microbiol. 22:355-365.
10. Lombardi VC, et al. 2009. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science 326: 585-589.
11. Lo SC, et al. 2010. Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors. Proc. Natl. Acad. Sci. U. S. A. 107:15874-15879.
12. Groom HC, Bishop KN. 2012. The tale of xenotropic murine leukemia virus-related virus. J. Gen. Virol. 93:915-924.
13. Erlwein O, et al. 2010. Failure to detect the novel retrovirus XMRV in chronic fatigue syndrome. PLoS One 5:e8519.
14. Groom HC, et al. 2010. Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. Retrovirology 7:10.
15. Hong P, Li J, Li Y. 2010. Failure to detect xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome. Virol. J. 7:224.
16. Knox K, et al. 2011. No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected. Science 333:94-97.
17. Henrich TJ, et al. 2010. Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immu-nomodulatory conditions. J. Infect. Dis. 202:1478-1481.
18. Switzer WM, et al. 2010. Absence of evidence of xenotropic murine leukemia virus-related virus infectionin persons with chronic fatigue syndrome and healthy controls in the United States. Retrovirology 7:57.
19. Paprotka T, et al. 2011. Recombinant origin of the retrovirus XMRV. Science 333:97-101.
20. Carruthers BM, et al. 2003. Myalgic encephalomyelitis/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols. J. Chronic Fatigue Syndr. 11:7-36.
21. Fukuda K, et al. 1994. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann. Intern. Med. 121:953-959.
22. Hays RD, Morales LS. 2001. The RAND-36 measure of health-related quality of life. Ann. Med. 33:350-357.
23. Crooks V, Waller S, Smith T, Hahn TJ. 1991. The use of the Karnofsky Performance Scale in determining outcomes and risk in geriatric outpatients. J. Gerontol. 46:M139-M144.
24. Walker MP, Schlaberg R, Hays AP, Bowser R, Lipkin WI. 2001. Absence of echovirus sequences in brain and spinal cord of amyotrophic lateral sclerosis patients. Ann. Neurol. 49:249-253.
25. Hornig M, et al. 2008. Lack of association between measles virus vaccine and autism with enteropathy: a case-control study. PLoS One 3:e3140.
26. Tuke PW, Tettmar KI, Tamuri A, Stoye JP, Tedder RS. 2011. PCR master mixes harbour murine DNA sequences. Caveat emptor! PLoS One 6:e19953.
27. Zheng H, Jia H, Shankar A, Heneine W, Switzer WM. 2011. Detection of murine leukemia virus or mouse DNAin commercial RT-PCR reagents and human DNAs. PLoS One 6:e29050.
28. Lipkin WI. 2010. Microbe hunting. Microbiol. Mol. Biol. Rev. 74: 363-377.
29. Pocock SJ, Ashby D, Shaper AG, Walker M, Broughton PM. 1989. Diurnal variations in serum biochemical and haematological measurements. J. Clin. Pathol. 42:172-179.
30. Ware JE, Jr, Sherbourne CD. 1992. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med. Care 30:473-483.
31. Smets EM, Garssen B, Bonke B, De Haes JC. 1995. The Multidimensional Fatigue Inventory (MFI) psychometric qualitiesof an instrument to assess fatigue. J. Psychosom. Res. 39:315-325.
32. Kearney MF, et al. 2011. Nucleic acid, antibody, and virus culture meth-odstodetect xenotropic MLV-related virusinhuman blood samples. Adv. Virol. 2011:272193.
33. Knouf EC, et al. 2009. Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells. J.Virol. 83:7353-7356.
34. Satterfield BC, et al. 2011. Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses. Retrovi-rology 8:12.
35. Switzer WM, et al. 2011. No evidence of murine leukemia virus-related viruses in live attenuated human vaccines. PLoS One 6:e29223.
36. Simmons G, et al. 2011. Failure to confirm XMRV/MLVs in the blood of patients with chronic fatigue syndrome: a multi-laboratory study. Science 334:814-817.
37. Oakes B, et al. 2010. Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences. Retrovirology 7:109.
38. Lee LL, Lin L, Bell DS, Levine S, Hanson MR. 2012. Sensitivity of PCR assays for murine gammaretroviruses and mouse contamination in human blood samples. PLoS One 7:e37482.
39. Robinson MJ, et al. 2010. Mouse DNA contamination in human tissue tested for XMRV. Retrovirology 7:108.