Evaluation of tumorigenic potential of high yielding cloned MDCK cells for live-attenuated influenza vaccine using in vitro growth characteristics, metastatic gene expression and in vivo nude mice model

Biologicals

Volumn 40, Issue 6, 2012, Pages 482-494

  Vepachedu, Ramarao S ^a   Menon, Amritha ^a   Hussain, Althaf I ^a   Liu, Jonathan ^a  

^a MEDIMMUNE   (United States)

Author keywords

In vitro assays; Influenza virus; MDCK cells; Tumorigenicity; Vaccine safety

Indexed keywords

INFLUENZA VACCINE;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL CLONE; CELL LINE; CELL STRAIN; CELL STRAIN MDCK 9B9 1E4; CONTROLLED STUDY; DRUG SAFETY; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE C MYC; ONCOGENE H RAS; PHENOTYPE; PRIORITY JOURNAL; QUALITY CONTROL PROCEDURES; VACCINE PRODUCTION; VIRUS INACTIVATION;

ANIMALS; BASE SEQUENCE; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA PRIMERS; DOGS; FEMALE; GENE EXPRESSION PROFILING; INFLUENZA VACCINES; MICE; MICE, NUDE; MODELS, ANIMAL; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; ONCOGENES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

MAMMALIA; MUS MUSCULUS; ORTHOMYXOVIRIDAE;

EID: 84868375204     PISSN: 10451056     EISSN: 10958320     Source Type: Journal    
DOI: 10.1016/j.biologicals.2012.06.005     Document Type: Article

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