Focus on Molecules: ADAMTSL4

Experimental Eye Research

Volumn 104, Issue , 2012, Pages 95-96

  Chandra, Aman ^a,b,c   D'Cruz, Leon ^b   Aragon Martin, Jose A ^b   Charteris, David G ^a,c   Limb, G Astrid ^a   Child, Anne H ^b   Arno, Gavin ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

ADAMTSL4; Ectopia lentis; Lens

Indexed keywords

ADAMTSL4 PROTEIN; AGGRECANASE 1; FIBRILLIN 1; UNCLASSIFIED DRUG;

ANGIOGENESIS; ECTOPIA LENTIS; GENE DELETION; GENE FREQUENCY; HOMOZYGOSITY; HUMAN; LENS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; SHORT SURVEY;

EYE DISEASES; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; THROMBOSPONDINS;

EID: 84868367777     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.12.007     Document Type: Short Survey

References (4)

1. Apte S.S. A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J. Biol. Chem. 2009, 284:31493-31497.
2. Aragon-Martin J.A., Ahnood D., Charteris D.G., Saggar A., Nischal K.K., Comeglio P., Chandra A., Child A.H., Arno G. Role of ADAMTSL4 mutations in FBN1 mutation-negative ectopia lentis patients. Hum. Mut. 2010, 31:E1622-E1631.
3. Buchner D.A., Meisler M.H. TSRC1, a widely expressed gene containing seven thrombospondin type I repeats. Gene 2003, 307:23-30.
4. Gabriel, L. A., Wang, L. W., Bader, H., Ho, J. C., Majors, A. K., Hollyfield, J. G., Traboulsi, E. I. and Apte, S. S. In press. ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis. Invest. Ophthalmol. Vis. Sci. 2011 Oct 11.