Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine in healthy Korean subjects

Journal of Clinical Pharmacy and Therapeutics

Volumn 37, Issue 6, 2012, Pages 698-703

  Lee, S ^a   Kim, B H ^a   Lim, K ^a   Stalker, D ^b   Wisemandle, W ^b   Shin, S G ^a   Jang, I J ^a   Yu, K S ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Hospira Inc   (United States)

Author keywords

dexmedetomidine; Korean; pharmacodynamics; pharmacokinetics; population pharmacokinetics

Indexed keywords

DEXMEDETOMIDINE; GLYCOPYRRONIUM BROMIDE; PLACEBO;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE; BLOOD SAMPLING; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG CLEARANCE; DRUG TOLERABILITY; ELECTROCARDIOGRAM; HEART RATE; HUMAN; KOREA; LABORATORY TEST; NAUSEA; NORMAL HUMAN; OXYGEN SATURATION; PHARMACODYNAMICS; PHYSICAL EXAMINATION; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEDATION; SINUS ARREST; VISUAL ANALOG SCALE; VITAL SIGN;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ADULT; AREA UNDER CURVE; DEXMEDETOMIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HUMANS; HYPNOTICS AND SEDATIVES; INFUSIONS, INTRAVENOUS; MALE; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; REPUBLIC OF KOREA; TISSUE DISTRIBUTION;

EID: 84868365851     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2012.01357.x     Document Type: Article

References (17)

1. Savola JM, Virtanen R,. Central alpha 2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine. Eur J Pharmacol, 1991; 195: 193-199.
2. Virtanen R, Savola JM, Saano V, Nyman L,. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol, 1988; 150: 9-14.
3. Bhana N, Goa KL, McClellan KJ,. Dexmedetomidine. Drugs, 2000; 59: 263-268; discussion 69-70.
4. Hospira. Precedex (dexmedetomidine hydrochloride injection) prescribing information, 2008.
5. Esmaoglu A, Ulgey A, Akin A, Boyaci A,. Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit. J Crit Care, 2009; 24: 551-555.
6. Cortinez LI, Hsu YW, Sum-Ping ST, et al. Dexmedetomidine pharmacodynamics: part II: crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology, 2004; 101: 1077-1083.
7. Dyck JB, Maze M, Haack C, Vuorilehto L, Shafer SL,. The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology, 1993; 78: 813-820.
8. Venn RM, Karol MD, Grounds RM,. Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive caret. Br J Anaesth, 2002; 88: 669-675.
9. Hsu YW, Cortinez LI, Robertson KM, et al. Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology, 2004; 101: 1066-1076.
10. Dyck JB, Maze M, Haack C, Azarnoff DL, Vuorilehto L, Shafer SL,. Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology, 1993; 78: 821-828.
11. Petroz GC, Sikich N, James M, et al. A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children. Anesthesiology, 2006; 105: 1098-1110.
12. Potts AL, Warman GR, Anderson BJ,. Dexmedetomidine disposition in children: a population analysis. Paediatr Anaesth, 2008; 18: 722-730.
13. Su F, Nicolson SC, Gastonguay MR, et al. Population pharmacokinetics of dexmedetomidine in infants after open heart surgery. Anesth Analg, 2010; 110: 1383-1392.
14. Talke P, Richardson CA, Scheinin M, Fisher DM,. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg, 1997; 85: 1136-1142.
15. Lin L, Guo X, Zhang MZ, Qu CJ, Sun Y, Bai J,. Pharmacokinetics of dexmedetomidine in Chinese post-surgical intensive care unit patients. Acta Anaesthesiol Scand, 2011; 55: 359-367.
16. Zhang X, Schmidt U, Wain JC, Bigatello L,. Bradycardia leading to asystole during dexmedetomidine infusion in an 18 year-old double-lung transplant recipient. J Clin Anesth, 2010; 22: 45-49.
17. Nagasaka Y, Machino A, Fujikake K, Kawamoto E, Wakamatsu M,. Cardiac arrest induced by dexmedetomidine. Masui, 2009; 58: 987-989.