C-myc and N-myc in the developing brain

Aging

Volumn 2, Issue 5, 2010, Pages 261-262

  Wey, Alice ^a   Knoepfler, Paul S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84868349537     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100151     Document Type: Note

References (6)

1. Knoepfler PS, PF Cheng and RN Eisenman. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev 2002. 16: 2699-2712.
2. Hatton BA et al. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res 2006. 66: 8655-8661.
3. van Bokhoven H et al. MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. Nat Genet 2005. 37: 465-467.
4. Knoepfler PS et al. Myc influences global chromatin structure. Embo J 2006. 25: 2723-2734.
5. Cotterman R, et al. N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor. Cancer Res 2008. 68: 9654-9662.
6. Wey A and PS. Knoepfler. c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain. OncoTarget 2010. 1.