Remodeling of intrinsic cardiac neurons: Effects of β-adrenergic receptor blockade in guinea pig models of chronic heart disease

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 303, Issue 9, 2012, Pages

  Hardwick, Jean C ^a   Marie Southerland, E ^b   Girasole, Allison E ^a   Ryan, Shannon E ^a   Negrotto, Sara ^b   Ardell, Jeffrey L ^b  

^a ITHACA COLLEGE   (United States)

^b East Tennessee State University   (United States)

Author keywords

Angiotensin II; Intracardiac; Myocardial infarction; Pressure overload; Timolol

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ANGIOTENSIN II; BETHANECHOL; NORADRENALIN; TIMOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CHRONIC DISEASE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; HEART DISEASE; HEART INFARCTION; HEART VENTRICLE OVERLOAD; MALE; NERVE CELL; NONHUMAN; OSMOTIC PUMP; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; ANIMAL CELL; DESCENDING AORTA; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG INHIBITION; GUINEA PIG; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; INTRINSIC CARDIAC NEURON; NERVE CELL EXCITABILITY; NERVE FIBER; NERVE PLEXUS; NERVE TRACT; TREATMENT DURATION; VASOCONSTRICTION; VEIN; ANIMAL; DISEASE MODEL; DRUG EFFECT; HEART; INNERVATION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENERGIC AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANGIOTENSIN II; ANIMALS; CHOLINERGIC AGENTS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; EVOKED POTENTIALS; GUINEA PIGS; HEART; HEART DISEASES; MALE; MYOCARDIAL INFARCTION; NEURONS; RECEPTORS, ADRENERGIC, BETA; TIMOLOL;

EID: 84868343127     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00223.2012     Document Type: Article

References (24)

1. Armour JA. Potential clinical relevance of the "little brain" on the mammalian heart. Exp Physiol 93: 165-176, 2008.
2. Arora RC, Cardinal R, Smith FM, Ardell JL, Dell'Italia LJ, Armour JA. Intrinsic cardiac nervous system in tachycardia induced heart failure. Am J Physiol Regul Integr Comp Physiol 285: R1212-R1223, 2003.
3. Bratton B, Davies P, Janig W, McAllen R. Ganglionic transmission in a vasomotor pathway studied in vivo. J Physiol 588: 1647-1659, 2010.
4. Caughey GH, Beauchamp J, Schlatter D, Raymond WW, Trivedi NN, Banner D, Mauser H, Fingerle J. Guinea pig chymase is leucinespecific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases. J Biol Chem 283: 13943-13951, 2008.
5. Clarke GL, Bhattacherjee A, Tague SE, Hasan W, Smith PG. ssadrenoceptor blockers increase cardiac sympathetic innervation by inhibiting autoreceptor suppression of axon growth. J Neurosci 30: 12446-12454, 2010.
6. Dell'Italia LJ. Translational success stories: angiotensin receptor 1 antagonists in heart failure. Circ Res 109: 437-452, 2011.
7. Dell'Italia LJ, Ardell JL. Sympathetic nervous system in the evolution of heart failure. In: Basic and Clinical Neurocardiology, edited by Armour JA and Ardell JL. Oxford, UK: Oxford University, 2004.
8. Girasole AE, Palmer CP, Corrado SL, Marie SE, Ardell JL, Hardwick JC. Angiotensin II potentiates adrenergic and muscarinic modulation of guinea pig intracardiac neurons. Am J Physiol Regul Integr Comp Physiol 301: R1391-R1399, 2011.
9. Gonzalez GE, Seropian IM, Krieger ML, Palleiro J, Lopez Verrilli MA, Gironacci MM, Cavallero S, Wilensky L, Tomasi VH, Gelpi RJ, Morales C. Effect of early versus late AT(1) receptor blockade with losartan on postmyocardial infarction ventricular remodeling in rabbits. Am J Physiol Heart Circ Physiol 297: H375-H386, 2009.
10. Hankes GH, Ardell JL, Tallaj J, Wei CC, Aban I, Holland M, Rynders P, Dillon R, Cardinal R, Hoover DB, Armour JA, Husain A, Dell'Italia LJ. Beta1-adrenoceptor blockade mitigates excessive norepinephrine release into cardiac interstitium in mitral regurgitation in dog. Am J Physiol Heart Circ Physiol 291: H147-H151, 2006.
11. Hardwick JC, Baran CN, Southerland EM, Ardell JL. Remodeling of the guinea pig intrinsic cardiac plexus with chronic pressure overload. Am J Physiol Regul Integr Comp Physiol 297: R859-R866, 2009.
12. Hardwick JC, Mawe GM, Parsons RL. Evidence for afferent fiber innervation of parasympathetic neurons of the guinea-pig cardiac ganglion. J Auton Nerv Syst 53: 166-174, 1995.
13. Hardwick JC, Southerland EM, Ardell JL. Chronic myocardial infarction induces phenotypic and functional remodeling in the guinea pig cardiac plexus. Am J Physiol Regul Integr Comp Physiol 295: R1926-R1933, 2008.
14. Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF. Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5. Heart Fail Rev 15: 495-512, 2010.
15. Kullmann PH, Horn JP. Excitatory muscarinic modulation strengthens virtual nicotinic synapses on sympathetic neurons and thereby enhances synaptic gain. J Neurophysiol 96: 3104-3113, 2006.
16. Li W, Knowlton D, Van Winkle DM, Habecker BA. Infarction alters both the distribution and noradrenergic properties of cardiac sympathetic neurons. Am J Physiol Heart Circ Physiol 286: H2229-H2236, 2004.
17. Mackins CJ, Kano S, Seyedi N, Schafer U, Reid AC, Machida T, Silver RB, Levi R. Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. J Clin Invest 116: 1063-1070, 2006.
18. Malpas SC. Sympathetic nervous system overactivity and its role in the development of cardiovascular disease. Physiol Rev 90: 513-557, 2010.
19. Miyazaki M, Takai S, Jin D, Muramatsu M. Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models. Pharmacol Ther 112: 668-676, 2006.
20. Morrey C, Brazin J, Seyedi N, Corti F, Silver RB, Levi R. Interaction between sensory C-fibers and cardiac mast cells in ischemia/reperfusion: activation of a local renin-angiotensin system culminating in severe arrhythmic dysfunction. J Pharmacol Exp Ther 335: 76-84, 2010.
21. Ng J, Villuendas R, Cokic I, Schliamser JE, Gordon D, Koduri H, Benefield B, Simon J, Murthy SN, Lomasney JW, Wasserstrom JA, Goldberger JJ, Aistrup GL, Arora R. Autonomic remodeling in the left atrium and pulmonary veins in heart failure: creation of a dynamic substrate for atrial fibrillation. Circ Arrhythm Electrophysiol 4: 388-396, 2011.
22. Parrish DC, Alston EN, Rohrer H, Nkadi P, Woodward WR, Schutz G, Habecker BA. Infarction-induced cytokines cause local depletion of tyrosine hydroxylase in cardiac sympathetic nerves. Exp Physiol 95: 304-314, 2010.
23. Porter TR, Eckberg DL, Fritsch JM, Rea RF, Beightol LA, Schmedtje JF Jr, Mohanty PK. Autonomic pathophysiology in heart failure patients Sympathetic-cholinergic interrelations. J Clin Invest 85: 1362-1371, 1990.
24. Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J. The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. J Am Coll Cardiol 54: 1747-1762, 2009.