Observing the mouse thyroid sphingomyelin under space conditions: A case study from the MDS mission in comparison with hypergravity conditions

Astrobiology

Volumn 12, Issue 11, 2012, Pages 1035-1041

  Albi, E ^a   Curcio, F ^b   Spelat, R ^b   Lazzarini, A ^a,b   Lazzarini, R ^a   Loreti, E ^c   Ferri, I ^c   Ambesi Impiombato, F S ^b  

^a Laboratory of Nuclear Lipid BioPathology   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

SPHINGOMYELIN;

ANIMAL; ARTICLE; C57BL MOUSE; CELL NUCLEUS; COMPARATIVE STUDY; GRAVITY; MALE; METABOLISM; MOUSE; SPACE FLIGHT; THYROID GLAND; WEIGHTLESSNESS;

ANIMALS; CELL NUCLEUS; HYPERGRAVITY; MALE; MICE; MICE, INBRED C57BL; SPACE FLIGHT; SPHINGOMYELINS; THYROID GLAND; WEIGHTLESSNESS;

ANIMALIA;

EID: 84868343093     PISSN: 15311074     EISSN: None     Source Type: Journal    
DOI: 10.1089/ast.2012.0881     Document Type: Article

References (9)

1. Albi, E., Cataldi, S., Rossi, G., Viola Magni, M., Toller, M., Casani, S., and Perrella, G. (2008) The nuclear ceramide/diacylglycerol balance depends on the physiological state of thyroid cells and changes during UV-C radiation induced apoptosis. Arch Biochem Biophys 478:52-58
2. Albi, E., Ambesi-Impiombato, S., Villani, M., De Pol, I., Spelat, R., Lazzarini, R., and Perrella, G. (2010) Thyroid cell growth: Sphingomyelin metabolism as non-invasive marker for cell damage acquired during spaceflight. Astrobiology 10:811-820
3. Albi, E., Ambesi-Impiombato, F.S., Peverini, M., Damaskopoulou, E., Fontanini, E., Lazzarini, R., Curcio, F., and Perrella, G. (2011) Thyrotropin receptor and membrane interactions in FRTL-5 thyroid cell strain in microgravity. Astrobiology 11:57-64
4. Cancedda, R., Pignataro, S., Alberici, G., and Tenconi, C. (2002) Mice Drawer System: phase c/d development and perspective. J Gravit Physiol 9:337-338
5. Edidin, M. (2003) The state of lipid rafts: From model membrane to cells. Annu Rev Biophys Biomol Struct 32:257-283
6. Latif, R., Ando, T., Daniel, S., and Davies, T.F. (2003) Localization and regulation of thyrotropin receptors within lipid rafts. Endocrinology 144:4725-4728
7. Latif, R., Ando, T., and Davies, T.F. (2007) Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology 148:3164-3175
8. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein measurement with folin phenol reagent. J Biol Chem 193:265-275
9. Masini, M.A., Albi, E., Barmo, C., Bonfiglio, T., Bruni, L., Canesi, L., Cataldi, S., Curcio, F., D'Amora, M., Ferri, I., Goto, K., Kawano, F., Lazzarini, R., Loreti, E., Nakai, N., Ohira, T., Ohira, Y., Palmero, S., Prato, P., Ricci, F., Scarabelli, L., Shibaguchi, T., Spelat, R., Strollo, F., and Ambesi-Impiombato, F.S. (2012) The impact of long-term exposure to space environment on adult mammalian organisms: A study on mouse thyroid and testis. PLoS One 7, e35418