Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model

Journal of Translational Medicine

Volumn 10, Issue 1, 2012, Pages

  Ruf, Peter ^a   Schäfer, Beatrix ^a   Eissler, Nina ^b   Mocikat, Ralph ^b   Hess, Juergen ^c   Plöscher, Matthias ^c   Wosch, Susanne ^a   Suckstorff, Ivonne ^a   Zehetmeier, Christine ^a   Lindhofer, Horst ^a,c  

^a TRION Research GmbH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c TRION Pharma GmbH   (Germany)

Author keywords

Ganglioside GD2; Immunotherapy; Melanoma; Trifunctional bispecific asntibody

Indexed keywords

BISPECIFIC ANTIBODY; CD3 ANTIGEN; GANGLIOSIDE GD2; GD2 SYNTHASE; GD3 SYNTHASE; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G3; SYNTHETASE; TRIFUNCTIONAL BISPECIFIC ANTIBODY SUREK; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CANCER IMMUNIZATION; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFICACY; DRUG PROTEIN BINDING; GENETIC TRANSFECTION; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; LONG TERM MEMORY; MEDIAN EFFECTIVE CONCENTRATION; MELANOMA; MOUSE; NONHUMAN; PROTECTION; TUMOR CELL DESTRUCTION;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, NEOPLASM; ANTIBODY SPECIFICITY; CYTOTOXICITY, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GANGLIOSIDES; HUMANS; IMMUNE SERA; IMMUNITY, HUMORAL; IMMUNIZATION; IMMUNOGLOBULIN G; MELANOMA; MICE; SKIN NEOPLASMS; SURVIVAL ANALYSIS; T-LYMPHOCYTES; TIME FACTORS; TREATMENT OUTCOME;

EID: 84868318334     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-10-219     Document Type: Article

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