Progestin-dependent effect of oral contraceptives on plasma aldosterone/renin ratio

Clinical Biochemistry

Volumn 45, Issue 16-17, 2012, Pages 1516-1518

  Locsei, Zoltán ^a   Horváth, Dóra ^a   Rácz, Károly ^b   Szabolcs, István ^b,c   Kovács, Gábor L ^d   Toldy, Erzsébet ^a,d  

^a Markusovszky Teaching Hospital   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c NATIONAL MEDICAL CENTER   (Hungary)

^d UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Aldosterone plasma renin activity ratio; Aldosterone plasma renin concentration ratio; Oral contraceptives; Progestin

Indexed keywords

ALDOSTERONE; DESOGESTREL; DROSPIRENONE; GESTAGEN; GESTODENE; ORAL CONTRACEPTIVE AGENT; RENIN;

ADULT; ALDOSTERONE BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE ACTION; HORMONE DETERMINATION; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

ADULT; ALDOSTERONE; ANDROSTENES; CONTRACEPTIVES, ORAL, SYNTHETIC; DESOGESTREL; ETHINYL ESTRADIOL; FEMALE; HUMANS; NORPREGNENES; PROGESTINS; RENIN; RENIN-ANGIOTENSIN SYSTEM; YOUNG ADULT;

EID: 84868302556     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.06.025     Document Type: Article

References (15)

1. Funder J.W., Carey R.M., Fardella C., Gomez-Sanchez C.E., Mantero F., Stowasser M., et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism, an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2008, 93:3266-3281.
2. Stowasser M., Taylor P.J., Pimenta E., Ahmed A.H., Gordon R.D. Laboratory investigation of primary aldosteronism. Clin. Biochem. Rev. 2010, 31:39-56.
3. de Bruin R.A., Bouhuizen A., Diederich S., Perschel F.H., Boomsma F., Deinum J. Validation of a new automated renin assay. Clin Chem 2004, 50:2111-2116.
4. Hartman D., Sagnella G.A., Chesters C.A., Macgregor G.A. Direct renin assay and plasma renin activity assay compared. Clin Chem 2004, 50:2159-2161.
5. Cavalier E., Delanaye P., Krzesinski J.M., Chapelle J.P. Analytical variation in plasma renin activity: implications for the screening of primary aldosteronism. Clin Chem 2007, 53:803-804.
6. Derkx F.H., Steunkel C., Schalekamp M.P., Visser W., Huisveld I.H., Schalekamp M.A. Immunoreactive renin, prorenin, and enzymatically active renin in plasma during pregnancy and in women taking oral contraceptives. J Clin Endocrinol Metab 1986, 63:1008-1015.
7. Goldhaber S.Z., Hennekens C.H., Spark R.F., Evans D.A., Rosner B., Taylor J.O., et al. Plasma renin substrate, renin activity, and aldosterone levels in a sample of oral contraceptive users from a community survey. Am Heart J 1984, 107:119-122.
8. Ahmed A.H., Gordon R.D., Taylor P.J., Ward G., Pimenta E., Stowasser M. Are women more at risk of false-positive primary aldosteronism screening and unnecessary suppression testing than man?. J Clin Endocrinol Metab 2011, 96:340-346.
9. Ahmed A.H., Gordon R.D., Taylor P.J., Ward G., Pimenta F., Stowasser M. Effect of contraceptives on aldosterone/renin ratio may vary according to the components of contraceptive, renin assay method, and possibility route of administration. J Clin Endocrinol Metab 2011, 96:1-8.
10. Oelkers W., Helmerhorst F.M., Wuttke W., Heithecker R. Effect of an oral contraceptive containing drospirenone on the renin-angiotensin-aldosterone system in healthy female volunteers. Gynecol Endocrinol 2000, 14:204-213.
11. DeLeo V., LaMarca A., Morgante G., Lucani B., Nami R., Ciotta L., et al. Evaluation of plasma levels of renin-aldosterone and blood pressure in women over 35years treated with new oral contraceptives. Contraception 2001, 64:145-148.
12. Schwartz G.L., Turner S.T. Screening for primary aldosteronism in essential hypertension: diagnostic accuracy of the ratio of plasma aldosterone concentration to plasma renin activity. Clin Chem 2005, 51:386-394.
13. Pizzolo F., Pavan C., Corrocher R., Olivieri O. Laboratory diagnosis of primary aldosteronism, and drospirenonee-ethinylestradiol therapy. Am J Hypertens 2007, 20:1334-1337.
14. Daniels C.R., Eisen V., Slater J.D. The renin angiotensinogen reaction during pregnancy and oral contraception: estimation of kinetic parameters by an autologous plasma renin assay. J Endocrinol 1987, 112:465-472.
15. Kang A.K., Duncan J.A., Cattran D.C., Floras J.S., Lai V., Scholey J.W., et al. Effect of oral contraceptives on the renin angiotensin system and renal function. Am J Physiol Regul Integr Comp Physiol 2001, 280:R807-R813.