Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function

FASEB Journal

Volumn 26, Issue 11, 2012, Pages 4506-4516

  Yang, Chunzhang ^a   Matro, Joey C ^b   Huntoon, Kristin M ^a   Ye, Donald Y ^a   Huynh, Thanh T ^b   Fliedner, Stephanie M J ^b   Breza, Jan ^c   Zhuang, Zhengping ^a   Pacak, Karel ^b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

Author keywords

Histone deacetylase inhibitor; Paraganglioma; Pheochromocytoma; Succinate dehydrogenase subunit B

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE SUBUNIT B; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MISSENSE MUTATION; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PULSE CHASE ASSAY; QUALITY CONTROL; QUANTITATIVE ANALYSIS;

CLONING, MOLECULAR; ENZYME STABILITY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HUMANS; MITOCHONDRIA; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PARAGANGLIOMA; PHEOCHROMOCYTOMA; PROTEIN BINDING; PROTEOLYSIS; RNA, MESSENGER; SUCCINATE DEHYDROGENASE;

EID: 84868298330     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-210146     Document Type: Article

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