High-performance method for specific effect on nucleic acids in cells using TiO 2 ∼dNA nanocomposites

Scientific Reports

Volumn 2, Issue , 2012, Pages

  Levina, Asya S ^a   Repkova, Marina N ^a   Ismagilov, Zinfer R ^b   Shikina, Nadezhda V ^b   Malygin, Ernst G ^c   Mazurkova, Natalia A ^c   Zinov'Ev, Victor V ^c   Evdokimov, Alexei A ^c   Baiborodin, Sergei I ^d   Zarytova, Valentina F ^a  

^a INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^b BORESKOV INSTITUTE OF CATALYSIS   (Russian Federation)

^c STATE RESEARCH CENTER OF VIROLOGY AND BIOTECHNOLOGY VECTOR   (Russian Federation)

^d INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; APTAMER; DRUG CARRIER; METAL NANOPARTICLE; NANOCOMPOSITE; POLYLYSINE; TITANIUM; TITANIUM DIOXIDE; VIRUS RNA;

3' UNTRANSLATED REGION; ANIMAL; ARTICLE; CELL SURVIVAL; CHEMISTRY; DOG; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; IC 50; INFLUENZA VIRUS A H3N2; MDCK CELL; SYNTHESIS; VIRUS LOAD; VIRUS REPLICATION;

3' UNTRANSLATED REGIONS; ANIMALS; ANTIVIRAL AGENTS; APTAMERS, NUCLEOTIDE; CELL SURVIVAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; INFLUENZA A VIRUS, H3N2 SUBTYPE; INHIBITORY CONCENTRATION 50; MADIN DARBY CANINE KIDNEY CELLS; METAL NANOPARTICLES; NANOCOMPOSITES; POLYLYSINE; RNA, VIRAL; TITANIUM; VIRAL LOAD; VIRUS REPLICATION;

EID: 84868297505     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00756     Document Type: Article

References (43)

1. Mescalchin, A. &, Restle, T. Oligomeric nucleic acids as antivirals. Molecules 16, 1271-1296 (2011).
2. Spurgers, K. B., Sharkey, C. M., Warfield, K. L. & Bavari, S. Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses. Antiviral Res 78, 26-36 (2008).
3. Seguin, R. M. & Ferrary, N. Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease. Expert Opin. Investig. Drugs 18, 1505-1517 (2009).
4. Silverman, S. K. in Functional Nucleic Acids For Analytical Applications, eds. Yingf, L. & Yi, L., N.Y., Springer, 47-108 (2009).
5. Bhindi, R. et al. DNA enzymes, short interfering RNA, and emerging wave of small-molecule nucleic acid-based gene-silencing strategies. Am. J. Path. 171, 1079-1088 (2007). (Pubitemid 47582883)
6. Bennett, C. F. & Swayze, E. E. RNA targeting therapeutics:molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu. Rev. Pharmacol. Toxicol. 50, 259-293 (2010).
7. Margus, H., Padari, K. & Pooga, M. Cell-penetrating peptides as versatile vehicles for oligonucleotide delivery. Mol. Ther. 20, 525-533 (2012).
8. Lim, K. I. Retroviral integration profiles: their determinants and implications for gene therapy. BMB Rep. 45, 207-212 (2012).
9. Bouard, D., Alazard-Dany, N. & Cosset, F-L. Viral vectors: from virology to transgene expression. British J. Pharm. 157, 153-165 (2009).
10. Hoyer, J. & Neundorf, I. Peptide vectors for the nonviral delivery of nucleic acids. Acc. Chem. Res. 45, 1048-1056 (2012).
11. Morille, M. et al. Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials 29, 3477-3496 (2008).
12. Donkuru, M. et al. Advancing nonviral gene delivery: lipid-And surfactant-based nanoparticle design strategies. Nanomedicine (Lond) 5, 1103-1127 (2010).
13. Koynova, R. & Tenchov, B. Recent patents in cationic lipid carriers for delivery of nucleic acids. Recent Pat. DNA Gene Seq. 5, 8-27 (2011).
14. Zhang, J. S., Liu, F. & Huang, L. Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity. Adv. Drug Deliv. Rev. 57, 689-698 (2005). (Pubitemid 40332597)
15. Yu, B., Zhao, X., Lee, L. J. & Lee, R. J. Targeted delivery systems for oligonucleotide therapeutics. AAPS J. 11, 195-203 (2009).
16. Jafari, M., Soltani, M., Naahidi, S., Karunaratne, D. N. & Chen, P. Nonviral approach for targeted nucleic acid delivery. Curr. Med. Chem. 19, 197-208 (2012).
17. Higuchi, Y., Kawakami, S. & Hashida, M. Strategies for in vivo delivery of siRNAs: recent progress. BioDrugs 24, 195-205 (2010).
18. Cho, K., Wang, X., Nie, S., Chen, Z. G. & Shin, D. M. Therapeutic nanoparticles for drug delivery in cancer. Clin. Cancer Res. 14, 1310-1316 (2008). (Pubitemid 351413909)
19. Marcato, P.D. & Durán, N. New aspects of nanopharmaceutical delivery systems. J. Nanosci. Nanotechnol. 8, 2216-2229 (2008).
20. Parveen, S., Misra, R. & Sahoo, S. K. Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine 8, 147-166 (2012).
21. 2 materials. Advanced Materials Research 79-82, 389-392 (2009).
22. Suzuki, H., Toyooka, T. & Ibuki, Y. Simple and easy method to evaluate uptake potential of nanoparticles in mammalian cells using a flow cytometric light scatter analysis. Environ. Sci. Technol. 41, 3018-3024 (2007). (Pubitemid 46626436)
23. Thurn, K. T. et al. Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells. Nanomedicine 7, 123-130 (2011).
24. Jeng, H. A. & Swanson, J. Toxicity of metal oxide nanoparticles in mammalian cells. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng. 41, 2699-2711 (2006).
25. 2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus. Chemosphere 71, 1308-1336 (2008).
26. 2. Part Fibre Toxicol. 8, 32-48 (2011).
27. Ismagilov, Z. R. et al. The effect of chemical treatment conditions of titanium dioxide sols on their dispersion and cytotoxic properties. Chem. Eng. Trans. 27, 241-246 (2012).
28. Fabian, E. et al. Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch. Toxicol. 82, 151-158 (2008).
29. Levina, A. et al. Nanocomposites consisting of titanium dioxide nanoparticles and oligonucleotides. J. Nanosci. Nanotech. 12, 1812-1820 (2012).
30. Levina, A., Pyshnaya, I., Repkova, M., Rar, V. & Zarytova, V. Oligonucleotide probes containing polylysine residues for fabrication of DNA chips on various solid surfaces. Biotechnol. J. 2, 879-885 (2007). (Pubitemid 47161992)
31. Lamb, R. A. & Krug, R. M. in Fundamental Virology, eds. Knipe, D.M. & Howely, P.M., Lippincott Williams and Wilkins, Philadelphia, 725-770 (2001).
32. Portela, A. & Digard, P. The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication. J. Gen. Virol. 83, 723-734 (2002). (Pubitemid 34284855)
33. Fodor, E., Pritlove, D. C. & Brownlee, G. G. The influenza virus panhandle is involved in the initiation of transcription. J. Virol. 68, 4092-4096 (1994). (Pubitemid 24177444)
34. Ge, Q. et al. Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers. Antimicrob. Agents Chemother. 50, 3724-3733 (2006). (Pubitemid 44684887)
35. Ge, Q. et al. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc. Natl. Acad. Sci. USA 100, 2718-2723 (2003). (Pubitemid 36297565)
36. Leiter, J., Agrawal, S., Palese, P. & Zamecnik, P. Inhibition of influenza virus replication by phosphorothioate oligodeoxynucleotides. Proc. Natl. Acad. Sci. USA 87, 3430-3434 (1990).
37. Beutner, R., Michael, J., Schwenzer, B. & Scharnweber, D. Biological nano-functionalization of titanium-based biomaterial surfaces: a flexible toolbox. J. R. Soc. Interface 7, S93-S105 (2010).
38. 2 (anatase) nanoparticles through a nonaqueous process and their surface functionalization. Langmuir 24, 6988-6997 (2008).
39. Zhang, T. et al. Antisense oligonucleotides targeting the RNA binding region of the NP gene inhibit replication of highly pathogenic avian influenza virus H5N1. Int. Immunopharmacol. 11, 2057-2061 (2011).
40. Zhang, T. et al. Antisense oligonucleotide inhibits avian influenza virus H5N1 replication by single chain antibody delivery system. Vaccine 29, 1558-1564 (2011).
41. Sui, H. Y et al. Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza A virus replication. PLoS One 4, e5671 (2009).
42. Zhou, H. et al. Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and mice. Antiviral Res. 76, 186-193 (2007). (Pubitemid 47410322)
43. Osano, E., Kishi, J. & Takahashi, Y. Phagocytosis of titanium particles and necrosis in TNF-Alpha-resistant mouse sarcoma L929 cells. Toxicol. In Vitro 17, 41-47 (2003). (Pubitemid 36106490)