Physical profile of counterfeit tablets Viagra® and Cialis®

Brazilian Journal of Pharmaceutical Sciences

Volumn 48, Issue 3, 2012, Pages 487-495

  Ortiz, Rafael Scorsatto ^a,b   Mariotti, Kristiane de Cássia ^b   Limberger, Renata Pereira ^b   Mayorga, Paulo ^b  

^a Brazilian Federal Police   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cialis ; Counterfeit drugs; Tablets physical characteristics; Viagra

Indexed keywords

SILDENAFIL; TADALAFIL;

ANALYSIS OF VARIANCE; ANALYTIC METHOD; ARTICLE; BRAZIL; FORENSIC SCIENCE; PHYSICAL PARAMETERS; POLICE; RELIABILITY; STATISTICAL ANALYSIS; TABLET; THICKNESS; VALIDITY;

EID: 84868288429     PISSN: 19848250     EISSN: 21759790     Source Type: Journal    
DOI: 10.1590/S1984-82502012000300016     Document Type: Article

References (22)

1. ALLEN, J.; LOYD, L.V.; POPOVICH, N.G.; ANSEL, H.C. (Eds.). Ansel's pharmaceutical dosage forms and drug delivery systems. 8.ed. Porto Alegre: Artmed, 2007. 775 p.
2. ANDERSSON, K.; JALAVA, K; LOCK, E.; FINNON, Y.; HUIZER, H.; KAA, E.; LOPES, A.; VAN DER MEER, A.P.; COLE, M.D.; DAHLÉN, J.; SIPPOLA, E. Development of a harmonised method for the profiling of amphetamines: III. Development of the gas chromatographic method. Forensic. Sci. Int., v.169, n.1, p.50-63, 2007.
3. BRASIL. Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Medicamentos falsificados. Brasília, 2008.
4. DE VEIJ, M.; DENECKERE, A.; VANDENABEELE, P.; DE KASTE, D.; MOENS, L. Detection of counterfeit Viagra® with raman spectroscopy. J. Pharm. Biomed. Anal, v.46, n.2, p.303-309, 2008.
5. DUJOURDY, L.; BESACIER, F. Headspace profiling of cocaine samples for intelligence purposes. Forensic. Sci. Int., v.179, n.2, p.111-122, 2008.
6. GENNARO, A.R. Remington: the science and practice of pharmacy. 20ed. Baltimore: Lippincott Williams & Wilkins, 2000. 2100 p.
7. BRUNTON, L.; CHABNER, B.; KNOLLMANN, B. Goodman and Gilman's: the pharmacological basis of therapeutics. 12ed. New York: McGraw-Hill, 2010. 1808 p.
8. HOLZGRABE, U.; Malet-Martino, M. Analytical challenges in drug counterfeiting and falsification-the NMR approach. J. Pharm. Biomed. Anal., v.55, n.4, p.679-687, 2011.
9. INOUE, H.; KANAMORI, T.; KUWAYAMA, K.; IWATA, Y.; SATOH, T.; YANAGIHORI, A.; MATSUSHIMA, K. Chemical profile of sildenafil and related compounds. Jpn. J. Forensic Sci. Tech., v.13, n.1, p.73-82, 2008.
10. LOCICIRO, S.; ESSEIVA, P.; HAYOZ, P.; DUJOURDY, L.; BESACIER, F.; MARGOT, P. Cocaine profiling for strategic intelligence, a cross-border project between France and Switzerland. Part II. Validation of the statistical methodology for the profiling of cocaine. Forensic Sci. Int., v.177, n.2, p.199-206, 2008.
11. MARQUIS, R.; WEYERMANN, C.; DELAPORTE, C.; ESSEIVA, P.; AALBERG, L.; BESACIER, F.; BOZENKO JR. J.S.; DAHLENBURG, R.; KOPPER, C.; ZRCEK, F. Drug intelligence based on MDMA tablets data. 2. Physical characteristics profiling, Forensic. Sci. Int., v.178, n.1, p.34-39, 2008.
12. MILLER, J.N.; MILLER, J.C. Estadística y quimiometría para química analítica. 4ed. Madrid: Pearson, 2002. 286 p.
13. MILLIET, Q.; WEYERMANN, C.; ESSEIVA, P. The profiling of MDMA tablets: a study of the combination of physical characteristics and organic impurities as sources of information. Forensic. Sci. Int., v.187, n.1, p.58-65, 2009.
14. ORTIZ, R.S.; ANTUNES, M.V.; LINDEN, R. Determinação de citrato de sildenafila e de tadalafila por cromatografia líquida de ultraeficiência com detecção por arranjo de diodos (CLUE-DAD). Quim. Nova, v.33, n.2, p.389-393, 2010.
15. SACRÉ, P.Y.; DECONINCK, E.; DE BEER, T.; COURSELLE, P.; VANCAUWENBERGHE, R.; CHIAP, P.; CROMMEN, J.; de BEER J.O. Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines. J. Pharm. Biomed. Anal, v.53, n.3, p.445-453, 2010.
16. SHAW, P.J.A. Multivariate statistics for the Environmental Sciences. London: Hodder Arnold, 2003. 248 p.
17. SINGH, S.; PRASAD, B.: SAVALIYA, A.; SHAH, R.; GOHIL, V.; KAUR, A. Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs. Trends Anal Chem., v.28, n.1, p.13-28, 2009.
18. VREDENBREGT, M.J.; Blok-Tip, L.; HOOGERBRUGGE, R.; BARENDS, D.M.; DE KASTE, D. Screening suspected counterfeit Viagra and imitations of Viagra with nearinfrared spectroscopy. J. Pharm. Biomed. Anal., v.40, n.4, p.840-849, 2006.
19. WEYERMANN, C.; MARQUIS, R.; DELAPORTE, C.; ESSEIVA, P.; LOCK, E.; AALBERG, L.; BOZENKO JR. J.S.; DIECKMANN, S.; DUJOURDY, L.; ZRCEK, F. Drug intelligence based on MDMA tablets data. I. Organic impurities profiling, Forensic. Sci. Int., v.177, n.1, p.11-16, 2008.
20. TREFI, S.; ROUTABOUL, C.; HAMIEH, S.; GILARD, V.; Malet-Martino, M.; MARTINO, R. Analysis of illegally manufactured formulations of tadalafil (cialis) by 1H NMR, 2D DOSY 1H NMR and Raman spectroscopy. J. Pharm. Biomed. Anal., v.47, n.1, p.103-113, 2008.
21. UNDCP. UNITED NATIONS INTERNATIONAL DRUG CONTROL PROGRAMME. Drug characterization/ impurity profiling: background and concepts. United Nations: New York, 2001. p.19.
22. UNODC. UNITED NATIONS OFFICE ON DRUGS AND CRIME. Methods for Impurity Profiling of Heroin and Cocaine. United Nations: New York, 2005. p.91.