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Volumn 7, Issue 10, 2012, Pages

A T Cell-Inducing Influenza Vaccine for the Elderly: Safety and Immunogenicity of MVA-NP+M1 in Adults Aged over 50 Years

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD45RO ANTIGEN; CD57 ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; INFLUENZA VACCINE; MODIFIED VACCINIA VIRUS ANKARA NUCLEOPROTEIN PLUS MATRIX PROTEIN 1 VACCINE; UNCLASSIFIED DRUG; VIRUS VECTOR;

EID: 84868283459     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048322     Document Type: Article
Times cited : (106)

References (29)
  • 1
    • 84865306914 scopus 로고    scopus 로고
    • Mortality caused by influenza and respiratory syncytial virus by age group in England and Wales 1999-2010
    • Hardelid P, Pebody R, Andrews N (2012) Mortality caused by influenza and respiratory syncytial virus by age group in England and Wales 1999-2010. Influenza Other Respi Viruses.
    • (2012) Influenza Other Respi Viruses
    • Hardelid, P.1    Pebody, R.2    Andrews, N.3
  • 2
    • 34548847744 scopus 로고    scopus 로고
    • Mortality benefits of influenza vaccination in elderly people: an ongoing controversy
    • Simonsen L, Taylor RJ, Viboud C, Miller MA, Jackson LA, (2007) Mortality benefits of influenza vaccination in elderly people: an ongoing controversy. Lancet Infect Dis 7: 658-666.
    • (2007) Lancet Infect Dis , vol.7 , pp. 658-666
    • Simonsen, L.1    Taylor, R.J.2    Viboud, C.3    Miller, M.A.4    Jackson, L.A.5
  • 4
    • 32044453088 scopus 로고    scopus 로고
    • Antibody response to influenza vaccination in the elderly: a quantitative review
    • Goodwin K, Viboud C, Simonsen L, (2006) Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 24: 1159-1169.
    • (2006) Vaccine , vol.24 , pp. 1159-1169
    • Goodwin, K.1    Viboud, C.2    Simonsen, L.3
  • 5
    • 84155162558 scopus 로고    scopus 로고
    • Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis
    • Osterholm MT, Kelley NS, Sommer A, Belongia EA, (2012) Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect Dis 12: 36-44.
    • (2012) Lancet Infect Dis , vol.12 , pp. 36-44
    • Osterholm, M.T.1    Kelley, N.S.2    Sommer, A.3    Belongia, E.A.4
  • 6
    • 0035915757 scopus 로고    scopus 로고
    • Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study
    • Olsson J, Wikby A, Johansson B, Löfgren S, Nilsson BO, et al. (2000) Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev 121: 187-201.
    • (2000) Mech Ageing Dev , vol.121 , pp. 187-201
    • Olsson, J.1    Wikby, A.2    Johansson, B.3    Löfgren, S.4    Nilsson, B.O.5
  • 7
  • 8
    • 78549241668 scopus 로고    scopus 로고
    • Influenza vaccines for the future
    • Lambert LC, Fauci AS, (2010) Influenza vaccines for the future. N Engl J Med 363: 2036-2044.
    • (2010) N Engl J Med , vol.363 , pp. 2036-2044
    • Lambert, L.C.1    Fauci, A.S.2
  • 9
    • 83055188639 scopus 로고    scopus 로고
    • T-cell-inducing vaccines - what's the future
    • Gilbert SC, (2012) T-cell-inducing vaccines- what's the future. Immunology 135: 19-26.
    • (2012) Immunology , vol.135 , pp. 19-26
    • Gilbert, S.C.1
  • 10
    • 0026442276 scopus 로고
    • Nonreplicating vaccinia vector efficiently expresses recombinant genes
    • Sutter G, Moss B, (1992) Nonreplicating vaccinia vector efficiently expresses recombinant genes. Proc Natl Acad Sci U S A 89: 10847-10851.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10847-10851
    • Sutter, G.1    Moss, B.2
  • 11
    • 79951645476 scopus 로고    scopus 로고
    • Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1
    • Berthoud TK, Hamill M, Lillie PJ, Hwenda L, Collins KA, et al. (2011) Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1. Clin Infect Dis 52: 1-7.
    • (2011) Clin Infect Dis , vol.52 , pp. 1-7
    • Berthoud, T.K.1    Hamill, M.2    Lillie, P.J.3    Hwenda, L.4    Collins, K.A.5
  • 12
    • 84862219175 scopus 로고    scopus 로고
    • A preliminary assessment of the efficacy of a T cell-based influenza vaccine, MVA-NP+M1, in humans
    • Lillie PJ, Berthoud TK, Powell TJ, Lambe T, Mullarkey C, et al. (2012) A preliminary assessment of the efficacy of a T cell-based influenza vaccine, MVA-NP+M1, in humans. Clin Infect Dis.
    • (2012) Clin Infect Dis.
    • Lillie, P.J.1    Berthoud, T.K.2    Powell, T.J.3    Lambe, T.4    Mullarkey, C.5
  • 13
    • 70649107756 scopus 로고    scopus 로고
    • Comparing human T cell and NK cell responses in viral-based malaria vaccine trials
    • Berthoud TK, Fletcher H, Porter D, Thompson F, Hill AV, et al. (2009) Comparing human T cell and NK cell responses in viral-based malaria vaccine trials. Vaccine 28: 21-27.
    • (2009) Vaccine , vol.28 , pp. 21-27
    • Berthoud, T.K.1    Fletcher, H.2    Porter, D.3    Thompson, F.4    Hill, A.V.5
  • 14
    • 27944505610 scopus 로고    scopus 로고
    • Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses
    • Price DA, Brenchley JM, Ruff LE, Betts MR, Hill BJ, et al. (2005) Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med 202: 1349-1361.
    • (2005) J Exp Med , vol.202 , pp. 1349-1361
    • Price, D.A.1    Brenchley, J.M.2    Ruff, L.E.3    Betts, M.R.4    Hill, B.J.5
  • 15
    • 82355184177 scopus 로고    scopus 로고
    • Unbiased molecular analysis of T cell receptor expression using template-switch anchored RT-PCR
    • Unit10.33
    • Quigley MF, Almeida JR, Price DA, Douek DC, (2011) Unbiased molecular analysis of T cell receptor expression using template-switch anchored RT-PCR. Curr Protoc Immunol Chapter 10: Unit10.33.
    • (2011) Curr Protoc Immunol Chapter , vol.10
    • Quigley, M.F.1    Almeida, J.R.2    Price, D.A.3    Douek, D.C.4
  • 16
    • 0037212339 scopus 로고    scopus 로고
    • IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains
    • Lefranc MP, Pommié C, Ruiz M, Giudicelli V, Foulquier E, et al. (2003) IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains. Dev Comp Immunol 27: 55-77.
    • (2003) Dev Comp Immunol , vol.27 , pp. 55-77
    • Lefranc, M.P.1    Pommié, C.2    Ruiz, M.3    Giudicelli, V.4    Foulquier, E.5
  • 17
    • 62749155684 scopus 로고    scopus 로고
    • Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults
    • McElhaney JE, Ewen C, Zhou X, Kane KP, Xie D, et al. (2009) Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults. Vaccine 27: 2418-2425.
    • (2009) Vaccine , vol.27 , pp. 2418-2425
    • McElhaney, J.E.1    Ewen, C.2    Zhou, X.3    Kane, K.P.4    Xie, D.5
  • 18
    • 79952816254 scopus 로고    scopus 로고
    • Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination
    • Miles JJ, Douek DC, Price DA, (2011) Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination. Immunol Cell Biol 89: 375-387.
    • (2011) Immunol Cell Biol , vol.89 , pp. 375-387
    • Miles, J.J.1    Douek, D.C.2    Price, D.A.3
  • 19
    • 0025992233 scopus 로고
    • Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide
    • Moss PA, Moots RJ, Rosenberg WM, Rowland-Jones SJ, Bodmer HC, et al. (1991) Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc Natl Acad Sci U S A 88: 8987-8990.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 8987-8990
    • Moss, P.A.1    Moots, R.J.2    Rosenberg, W.M.3    Rowland-Jones, S.J.4    Bodmer, H.C.5
  • 20
    • 0028909051 scopus 로고
    • Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment
    • Lehner PJ, Wang EC, Moss PA, Williams S, Platt K, et al. (1995) Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment. J Exp Med 181: 79-91.
    • (1995) J Exp Med , vol.181 , pp. 79-91
    • Lehner, P.J.1    Wang, E.C.2    Moss, P.A.3    Williams, S.4    Platt, K.5
  • 21
    • 78349284842 scopus 로고    scopus 로고
    • Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study
    • Amato RJ, Hawkins RE, Kaufman HL, Thompson JA, Tomczak P, et al. (2010) Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study. Clin Cancer Res 16: 5539-5547.
    • (2010) Clin Cancer Res , vol.16 , pp. 5539-5547
    • Amato, R.J.1    Hawkins, R.E.2    Kaufman, H.L.3    Thompson, J.A.4    Tomczak, P.5
  • 22
    • 2442440593 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of influenza vaccination
    • Hannoun C, Megas F, Piercy J, (2004) Immunogenicity and protective efficacy of influenza vaccination. Virus Res 103: 133-138.
    • (2004) Virus Res , vol.103 , pp. 133-138
    • Hannoun, C.1    Megas, F.2    Piercy, J.3
  • 23
    • 33947592372 scopus 로고    scopus 로고
    • Immunosenescence: role and measurement in influenza vaccine response among the elderly
    • Targonski PV, Jacobson RM, Poland GA, (2007) Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine 25: 3066-3069.
    • (2007) Vaccine , vol.25 , pp. 3066-3069
    • Targonski, P.V.1    Jacobson, R.M.2    Poland, G.A.3
  • 24
    • 34547773111 scopus 로고    scopus 로고
    • Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells
    • Kannanganat S, Ibegbu C, Chennareddi L, Robinson HL, Amara RR, (2007) Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells. J Virol 81: 8468-8476.
    • (2007) J Virol , vol.81 , pp. 8468-8476
    • Kannanganat, S.1    Ibegbu, C.2    Chennareddi, L.3    Robinson, H.L.4    Amara, R.R.5
  • 25
    • 34250303350 scopus 로고    scopus 로고
    • Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
    • Darrah PA, Patel DT, De Luca PM, Lindsay RW, Davey DF, et al. (2007) Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nature medicine 13: 843-850.
    • (2007) Nature Medicine , vol.13 , pp. 843-850
    • Darrah, P.A.1    Patel, D.T.2    De Luca, P.M.3    Lindsay, R.W.4    Davey, D.F.5
  • 26
    • 84862776821 scopus 로고    scopus 로고
    • The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines
    • McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, et al. (2012) The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine 30: 2060-2067.
    • (2012) Vaccine , vol.30 , pp. 2060-2067
    • McElhaney, J.E.1    Zhou, X.2    Talbot, H.K.3    Soethout, E.4    Bleackley, R.C.5
  • 28
    • 33646468500 scopus 로고    scopus 로고
    • T cell responses are better correlates of vaccine protection in the elderly
    • McElhaney JE, Xie D, Hager WD, Barry MB, Wang Y, et al. (2006) T cell responses are better correlates of vaccine protection in the elderly. J Immunol 176: 6333-6339.
    • (2006) J Immunol , vol.176 , pp. 6333-6339
    • McElhaney, J.E.1    Xie, D.2    Hager, W.D.3    Barry, M.B.4    Wang, Y.5
  • 29
    • 0037561928 scopus 로고    scopus 로고
    • Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
    • Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, et al. (2003) Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 101: 2711-2720.
    • (2003) Blood , vol.101 , pp. 2711-2720
    • Brenchley, J.M.1    Karandikar, N.J.2    Betts, M.R.3    Ambrozak, D.R.4    Hill, B.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.