Severe bleeding tendency caused by a rare complication of excessive fibrinolysis with disseminated intravascular coagulation in a 51-year-old Japanese man with prostate cancer: A case report

Journal of Medical Case Reports

Volumn 6, Issue , 2012, Pages

  Wada, Yoshihiro ^a   Uchiba, Mitsuhiro ^b   Kawano, Yoshiaki ^a   Kai, Nobuyuki ^a   Takahashi, Wataru ^a   Honda, Jiro ^a   Tanoue, Ken Ichiro ^a   Maeda, Yoshihiro ^a   Murakami, Yoji ^a   Eto, Masatoshi ^a   Imamura, Takahisa ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Castration resistant prostate cancer; Disseminated intravascular coagulation; Excessive fibrinolysis; Low molecular weight heparin; Tranexamic acid

Indexed keywords

ALPHA 2 ANTIPLASMIN; D DIMER; FIBRIN; FIBRIN DEGRADATION PRODUCT; FIBRIN MONOMER; FIBRINOGEN; FOSFESTROL; HEMOGLOBIN; LOW MOLECULAR WEIGHT HEPARIN; PLASMINOGEN ACTIVATOR; PROSTATE SPECIFIC ANTIGEN; THROMBIN ANTITHROMBIN COMPLEX; THROMBOPLASTIN; TRANEXAMIC ACID; UROKINASE;

ADULT; ANEMIA; ANTIANDROGEN THERAPY; ARTICLE; BLEEDING TENDENCY; BLOOD CLOTTING TIME; CANCER CELL; CANCER HORMONE THERAPY; CANCER PATIENT; CANCER RESISTANCE; CASE REPORT; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG MEGADOSE; FIBRINOGEN BLOOD LEVEL; FIBRINOGENOLYSIS; FIBRINOLYSIS; HEMOGLOBIN BLOOD LEVEL; HOSPITAL ADMISSION; HUMAN; HYPOFIBRINOGENEMIA; IMMUNOHISTOCHEMISTRY; JAPANESE; LEUKOCYTE COUNT; MALE; METASTASIS; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CANCER; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; PURPURA; THROMBOCYTE COUNT;

EID: 84868275714     PISSN: None     EISSN: 17521947     Source Type: Journal    
DOI: 10.1186/1752-1947-6-378     Document Type: Article

References (15)

1. Complications of advanced prostate cancer. Smith JA Jr, Soloway MS, Young MJ, Urology 1999 54 8 14 10.1016/S0090-4295(99)00448-3 10606278
2. Tissue factor expression and angiogenesis in human prostate carcinoma. Abdulkadir SA, Carvalhal GF, Kaleen Z, Kisiel W, Humphrey PA, Catalona WJ, Milbrandt J, Hum Pathol 2000 31 443 447 10.1053/hp.2000.6547 10821491 (Pubitemid 30262866)
3. Tissue factor and hemostasis. Nemerson Y, Blood 1998 71 1 8
4. Disseminated intravascular coagulation. Levi M, Crit Care Med 2007 35 2191 2195 10.1097/01.CCM.0000281468.94108.4B 17855836 (Pubitemid 47326459)
5. Evaluation of urokinase plasminogen activator and its receptor in different grades of human prostate cancer. Cozzi PJ, Wang J, Delprado W, Madigan MC, Fairy S, Russell PJ, Li Y, Hum Pathol 2006 37 1442 1451 10.1016/j.humpath.2006.05.002 16949925 (Pubitemid 44584322)
6. The mechanism of activation of human plasminogen by urokinase. Castelline JC, Violand BN, J Biol Chem 1976 251 3906 3912 132442
7. Disseminated intravascular coagulation as the presenting sign of metastatic prostate cancer. Duran I, Tannock IF, J Gen Intern Med 2006 21 6 C8 10.1111/j.1525-1497.2006.00506.x 17026724 (Pubitemid 44506862)
8. Tissue factor expression and prognosis in patients with metastatic prostate cancer. Akashi T, Furuya Y, Ohta S, Fuse H, Urology 2003 62 1078 1082 10.1016/S0090-4295(03)00768-4 14665359 (Pubitemid 37510095)
9. RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo. Pulukuri SM, Gondi CS, Lakka SS, Jutla A, Estes N, Gujrati M, Rao JS, J Biol Chem 2005 280 36529 36540 10.1074/jbc.M503111200 16127174 (Pubitemid 41633927)
10. New functions of neutrophils in the Arthus reaction: expression of tissue factor, the clotting initiator, and fibrinolysis by elastase. Imamura T, Kaneda H, Nakamura S, Lab Invest 2002 282 1287 1295 (Pubitemid 35191532)
11. Disseminated intravascular coagulation. Levi M, de Jonge E, van der Poll T, ten Cate H, Thromb Haemost 1999 82 695 705 10605770
12. Direct evidence for systemic fibrinogenolysis in patients with acquired alpha 2-plasmin inhibitor deficiency. Okajima K, Kohno I, Soe G, Okabe H, Takatsuki K, Binder BR, Am J Hematol 1994 45 16 24 10.1002/ajh.2830450104 8250008 (Pubitemid 23362870)
13. Direct evidence for systemic fibrinogenolysis in a patient with metastatic prostatic cancer. Okajima K, Kohno I, Tsuruta J, Okabe H, Takatsuki K, Binder BR, Thromb Res 1992 66 717 727 10.1016/0049-3848(92)90047-E 1519230
14. Acute renal cortical necrosis caused by an antifibrinolytic drug (tranexamic acid). Koo JR, Lee YK, Kim YS, Cho WY, Kim HK, Won NH, Nephrol Dial Transplant 1999 14 750 752 10.1093/ndt/14.3.750 10193833
15. Plasminogen activator system modulates invasive capacity and proliferation in prostatic tumor cells. Festuccia C, Dolo V, Guerra F, Violini S, Muzi P, Pavan A, Bologna M, Clin Exp Metastasis 1998 16 513 528 10.1023/A:1006590217724 9872599 (Pubitemid 29009587)