Non-pigmenting fixed drug eruption caused by an over-the-counter nonsteroidal anti-inflammatory drug: Drugspecific CD8+ T lymphocytes identified in peripheral blood

European Journal of Dermatology

Volumn 22, Issue 5, 2012, Pages 680-682

  Hanafusa, Takaaki ^a   Azukizawa, Hiroaki ^a   Matsumura, Sayaka ^a   Murakami, Yukako ^a   Tanaka, Aya ^b   Kurachi, Kishiro ^b   Katayama, Ichiro ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOYONAKA MUNICIPAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; APRONAL PLUS IBUPROFEN; C REACTIVE PROTEIN; EVE A; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BLOOD CELL COUNT; CASE REPORT; CD8+ T LYMPHOCYTE; DERMATITIS; EDEMA; EOSINOPHIL COUNT; ERYTHEMA; FEVER; FIXED DRUG ERUPTION; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JAPANESE; LABORATORY TEST; LYMPHOCYTE TRANSFORMATION TEST; LYMPHOCYTIC INFILTRATION; MENSTRUAL PAIN; MENSTRUATION DISORDER; MIGRAINE; MOUSE; NONHUMAN; NONPIGMENTING FIXED DRUG ERUPTION; PATCH TEST; PATIENT COMPLIANCE; PROTEIN BLOOD LEVEL; REMISSION; SKIN BIOPSY;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CD8-POSITIVE T-LYMPHOCYTES; DRUG ERUPTIONS; FEMALE; FLOW CYTOMETRY; HUMANS; IBUPROFEN;

EID: 84868273655     PISSN: 11671122     EISSN: 19524013     Source Type: Journal    
DOI: 10.1684/ejd.2012.1793     Document Type: Article

References (6)

1. Gendernalik SB, Galeckas KJ. Fixed drug eruptions: a case report and review of the literature. Cutis 2009; 84: 215-9.
2. Andrade P, Brinca A, Goncalo M. Patch testing in fixed drug eruptions-a 20-year review. Contact Dermatitis 2011; 65: 195-201.
3. Mizukawa Y, Yamazaki Y, Teraki Y, et al. Direct evidence for interferon-gamma production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption. Am J Pathol 2002; 161: 1337-47.
4. Shiohara T, Mizukawa Y. Fixed drug eruption: a disease mediated by self-inflicted responses of intraepidermal T cells. Eur J Dermatol 2007; 17: 201-8.
5. Hanafusa T, Azukizawa H, Matsumura S, Katayama I. The predominant drug-specific T-cell population may switch from cytotoxic T cells to regulatory T cells during the course of anticonvulsant-induced hypersensitivity. J Dermatol Sci 2012; 65: 213-9.
6. Teraki Y, Moriya N, Shiohara T. Drug-induced expression of intercellular adhesion molecule-1 on lesional keratinocytes in fixed drug eruption. Am J Pathol 1994; 145: 550-60.