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Volumn 1, Issue 8, 2012, Pages 299-316

Ensemble bayesian analysis of bistability in a synthetic transcriptional switch

Author keywords

In vitro; Reductionism; Synthetic biology; Systems biology; Transcriptional circuits

Indexed keywords

RIBONUCLEASE; RIBONUCLEASE H; RIBONUCLEASE R; RNA POLYMERASE; UNCLASSIFIED DRUG;

EID: 84868251212     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/sb300018h     Document Type: Article
Times cited : (49)

References (80)
  • 1
    • 33745454125 scopus 로고    scopus 로고
    • Synthetic biology: New engineering rules for an emerging discipline
    • 20060028
    • Andrianantoandro, E., Basu, S., Karig, D. K., and Weiss, R. (2006) Synthetic biology: New engineering rules for an emerging discipline. Mol. Syst. Biol. 2, No. 2006.0028.
    • (2006) Mol. Syst. Biol. , vol.2
    • Andrianantoandro, E.1    Basu, S.2    Karig, D.K.3    Weiss, R.4
  • 2
    • 21344458620 scopus 로고    scopus 로고
    • Synthetic biology
    • DOI 10.1038/nrg1637
    • Benner, S. A., and Sismour, A. M. (2005) Synthetic biology. Nat. Rev. Genet. 6, 533-543. (Pubitemid 40910430)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.7 , pp. 533-543
    • Benner, S.A.1    Sismour, A.M.2
  • 3
    • 77951107086 scopus 로고    scopus 로고
    • Synthetic biology: Applications come of age
    • Khalil, A. S., and Collins, J. J. (2010) Synthetic biology: Applications come of age. Nat. Rev. Genet. 11, 367-379.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 367-379
    • Khalil, A.S.1    Collins, J.J.2
  • 4
    • 28544451327 scopus 로고    scopus 로고
    • Foundations for engineering biology
    • DOI 10.1038/nature04342, PII N04342
    • Endy, D. (2005) Foundations for engineering biology. Nature 438, 449-453. (Pubitemid 41742010)
    • (2005) Nature , vol.438 , Issue.7067 , pp. 449-453
    • Endy, D.1
  • 6
    • 0033169046 scopus 로고    scopus 로고
    • Biotechnology as a route to nanotechnology
    • DOI 10.1016/S0167-7799(99)01335-9, PII S0167779999013359
    • Merkle, R. C. (1999) Biotechnology as a route to nanotechnology. Trends Biotechnol. 17, 271-274. (Pubitemid 29287248)
    • (1999) Trends in Biotechnology , vol.17 , Issue.7 , pp. 271-274
    • Merkle, R.C.1
  • 7
    • 77953310230 scopus 로고    scopus 로고
    • Structural DNA nanotechnology: Growing along with nano letters
    • Seeman, N. C. (2010) Structural DNA nanotechnology: Growing along with Nano Letters. Nano Lett. 10, 1971-1978.
    • (2010) Nano Lett. , vol.10 , pp. 1971-1978
    • Seeman, N.C.1
  • 8
    • 10044298236 scopus 로고    scopus 로고
    • Reductionism and complexity in molecular biology
    • Regenmortel, M. V. (2004) Reductionism and complexity in molecular biology. EMBO Rep. 5, 1016-1020.
    • (2004) EMBO Rep. , vol.5 , pp. 1016-1020
    • Regenmortel, M.V.1
  • 9
    • 77949479491 scopus 로고    scopus 로고
    • So what do we really mean when we say that systems biology is holistic?
    • Gatherer, D. (2010) So what do we really mean when we say that systems biology is holistic? BMC Syst. Biol. 4, 22.
    • (2010) BMC Syst. Biol. , vol.4 , pp. 22
    • Gatherer, D.1
  • 10
    • 78650334784 scopus 로고    scopus 로고
    • Build life to understand it
    • Elowitz, M., and Lim, W. A. (2010) Build life to understand it. Nature 468, 889-890.
    • (2010) Nature , vol.468 , pp. 889-890
    • Elowitz, M.1    Lim, W.A.2
  • 12
    • 77952903892 scopus 로고    scopus 로고
    • Rewiring cells: Synthetic biology as a tool to interrogate the organizational principles of living systems
    • Bashor, C. J., Horwitz, A. A., Peisajovich, S. G., and Lim, W. A. (2010) Rewiring cells: Synthetic biology as a tool to interrogate the organizational principles of living systems. Annu. Rev. Biophys. 39, 515-537.
    • (2010) Annu. Rev. Biophys. , vol.39 , pp. 515-537
    • Bashor, C.J.1    Horwitz, A.A.2    Peisajovich, S.G.3    Lim, W.A.4
  • 13
    • 75149167486 scopus 로고    scopus 로고
    • Five hard truths for synthetic biology
    • Kwok, R. (2010) Five hard truths for synthetic biology. Nature 463, 288-290.
    • (2010) Nature , vol.463 , pp. 288-290
    • Kwok, R.1
  • 14
    • 83255164998 scopus 로고    scopus 로고
    • Cell-free synthetic biology: Thinking outside the cell
    • Hodgman, C. E., and Jewett, M. C. (2012) Cell-free synthetic biology: Thinking outside the cell. Metab. Eng. 14, 261-269.
    • (2012) Metab. Eng. , vol.14 , pp. 261-269
    • Hodgman, C.E.1    Jewett, M.C.2
  • 15
    • 84899469245 scopus 로고    scopus 로고
    • Breaking down complexity
    • Rondelez, Y. (2011) Breaking down complexity. Physics 4, 8.
    • (2011) Physics , vol.4 , pp. 8
    • Rondelez, Y.1
  • 18
    • 26944433403 scopus 로고    scopus 로고
    • Toward an artificial cell based on gene expression in vesicles
    • Noireaux, V., Bar-Ziv, R., Godefroy, J., Salman, H., and Libchaber, A. (2005) Toward an artificial cell based on gene expression in vesicles. Phys. Biol. 2 (3), 1-8.
    • (2005) Phys. Biol. , vol.2 , Issue.3 , pp. 1-8
    • Noireaux, V.1    Bar-Ziv, R.2    Godefroy, J.3    Salman, H.4    Libchaber, A.5
  • 19
    • 23044504786 scopus 로고    scopus 로고
    • Protein synthesis by pure translation systems
    • DOI 10.1016/j.ymeth.2005.04.006, PII S1046202305000897, Engineering Translation
    • Shimizu, Y., Kanamori, T., and Ueda, T. (2005) Protein synthesis by pure translation systems. Methods 36, 299-304. (Pubitemid 41074961)
    • (2005) Methods , vol.36 , Issue.3 , pp. 299-304
    • Shimizu, Y.1    Kanamori, T.2    Ueda, T.3
  • 20
    • 53949093950 scopus 로고    scopus 로고
    • An integrated cell-free metabolic platform for protein production and synthetic biology
    • Jewett, M. C., Calhoun, K. A., Voloshin, A., Wuu, J. J., and Swartz, J. R. (2008) An integrated cell-free metabolic platform for protein production and synthetic biology. Mol. Syst. Biol. 4, 220.
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 220
    • Jewett, M.C.1    Calhoun, K.A.2    Voloshin, A.3    Wuu, J.J.4    Swartz, J.R.5
  • 21
    • 79952775158 scopus 로고    scopus 로고
    • Development of an artificial cell, from self-organization to computation and selfreproduction
    • Noireaux, V., Maeda, Y., and Libchaber, A. (2011) Development of an artificial cell, from self-organization to computation and selfreproduction. Proc. Natl. Acad. Sci. U.S.A. 108, 3473-3480.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 3473-3480
    • Noireaux, V.1    Maeda, Y.2    Libchaber, A.3
  • 22
    • 79251480753 scopus 로고    scopus 로고
    • Coarse-grained dynamics of protein synthesis in a cell-free system
    • Karzbrun, E., Shin, J., Bar-Ziv, R., and Noireaux, V. (2011) Coarse-grained dynamics of protein synthesis in a cell-free system. Phys. Rev. Lett. 106, 048104.
    • (2011) Phys. Rev. Lett. , vol.106 , pp. 048104
    • Karzbrun, E.1    Shin, J.2    Bar-Ziv, R.3    Noireaux, V.4
  • 23
    • 84860375823 scopus 로고    scopus 로고
    • Expression optimization and synthetic gene networks in cell-free systems
    • Karig, D. K., Iyer, S., Simpson, M. L., and Doktycz, M. J. (2012) Expression optimization and synthetic gene networks in cell-free systems. Nucleic Acids Res. 40, 3763-3774.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 3763-3774
    • Karig, D.K.1    Iyer, S.2    Simpson, M.L.3    Doktycz, M.J.4
  • 24
    • 84863610029 scopus 로고    scopus 로고
    • An E. coli cell-free expression toolbox: Application to synthetic gene circuits and artificial cells
    • Shin, J., and Noireaux, V. (2012) An E. coli cell-free expression toolbox: Application to synthetic gene circuits and artificial cells. ACS Synth. Biol. 1, 29-41.
    • (2012) ACS Synth. Biol. , vol.1 , pp. 29-41
    • Shin, J.1    Noireaux, V.2
  • 25
    • 0030887814 scopus 로고    scopus 로고
    • A molecular predator and its prey: Coupled isothermal amplification of nucleic acids
    • Wlotzka, B., and McCaskill, J. S. (1997) A molecular predator and its prey: Coupled isothermal amplification of nucleic acids. Chem. Biol. 4, 25-33. (Pubitemid 27158643)
    • (1997) Chemistry and Biology , vol.4 , Issue.1 , pp. 25-33
    • Wlotzka, B.1    McCaskill, J.S.2
  • 26
    • 0035936116 scopus 로고    scopus 로고
    • Programmable and autonomous computing machine made of biomolecules
    • DOI 10.1038/35106533
    • Benenson, Y., Paz-Elizur, T., Adar, R., Keinan, E., Livneh, Z., and Shapiro, E. (2001) Programmable and autonomous computing machine made of biomolecules. Nature 414, 430-434. (Pubitemid 34173721)
    • (2001) Nature , vol.414 , Issue.6862 , pp. 430-434
    • Benenson, Y.1    Paz-Elizur, T.2    Adar, R.3    Keinan, E.4    Llvneh, Z.5    Shapiro, E.6
  • 27
    • 2642555548 scopus 로고    scopus 로고
    • An autonomous molecular computer for logical control of gene expression
    • DOI 10.1038/nature02551
    • Benenson, Y., Gil, B., Ben-Dor, U., Adar, R., and Shapiro, E. (2004) An autonomous molecular computer for logical control of gene expression. Nature 429, 423-429. (Pubitemid 38715134)
    • (2004) Nature , vol.429 , Issue.6990 , pp. 423-429
    • Benenson, Y.1    Gil, B.2    Ben-Dor, U.3    Adar, R.4    Shapiro, E.5
  • 28
    • 17244373578 scopus 로고    scopus 로고
    • Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro
    • DOI 10.1126/science.1108451
    • Nakajima, M., Imai, K., Ito, H., Nishiwaki, T., Murayama, Y., Iwasaki, H., Oyama, T., and Kondo, T. (2005) Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro. Science 308, 414-415. (Pubitemid 40530079)
    • (2005) Science , vol.308 , Issue.5720 , pp. 414-415
    • Nakajima, M.1    Imai, K.2    Ito, H.3    Nishiwaki, T.4    Murayama, Y.5    Iwasaki, H.6    Oyama, T.7    Kondo, T.8
  • 30
    • 84255209210 scopus 로고    scopus 로고
    • RTRACS: A modularized RNA-dependent RNA transcription system with high programmability
    • Ayukawa, S., Takinoue, M., and Kiga, D. (2011) RTRACS: A modularized RNA-dependent RNA transcription system with high programmability. Acc. Chem. Res. 44, 1369-1379.
    • (2011) Acc. Chem. Res. , vol.44 , pp. 1369-1379
    • Ayukawa, S.1    Takinoue, M.2    Kiga, D.3
  • 31
    • 79551586208 scopus 로고    scopus 로고
    • Programming an in vitro DNA oscillator using a molecular networking strategy
    • Montagne, K., Plasson, R., Sakai, Y., Fujii, T., and Rondelez, Y. (2011) Programming an in vitro DNA oscillator using a molecular networking strategy. Mol. Syst. Biol. 7, 466.
    • (2011) Mol. Syst. Biol. , vol.7 , pp. 466
    • Montagne, K.1    Plasson, R.2    Sakai, Y.3    Fujii, T.4    Rondelez, Y.5
  • 32
    • 33845411737 scopus 로고    scopus 로고
    • Enzyme-free nucleic acid logic circuits
    • DOI 10.1126/science.1132493
    • Seelig, G., Soloveichik, D., Zhang, D. Y., and Winfree, E. (2006) Enzyme-free nucleic acid logic circuits. Science 314, 1585-1588. (Pubitemid 44907149)
    • (2006) Science , vol.314 , Issue.5805 , pp. 1585-1588
    • Seelig, G.1    Soloveichik, D.2    Zhang, D.Y.3    Winfree, E.4
  • 33
    • 36248972215 scopus 로고    scopus 로고
    • Engineering entropy-driven reactions and networks catalyzed by DNA
    • DOI 10.1126/science.1148532
    • Zhang, D. Y., Turberfield, A. J., Yurke, B., and Winfree, E. (2007) Engineering entropy-driven reactions and networks catalyzed by DNA. Science 318, 1121-1125. (Pubitemid 350134891)
    • (2007) Science , vol.318 , Issue.5853 , pp. 1121-1125
    • Zhang, D.Y.1    Turberfield, A.J.2    Yurke, B.3    Winfree, E.4
  • 35
    • 79960650829 scopus 로고    scopus 로고
    • Neural network computation with DNA strand displacement cascades
    • Qian, L., Winfree, E., and Bruck, J. (2011) Neural network computation with DNA strand displacement cascades. Nature 475, 368-372.
    • (2011) Nature , vol.475 , pp. 368-372
    • Qian, L.1    Winfree, E.2    Bruck, J.3
  • 36
  • 37
    • 33846116559 scopus 로고    scopus 로고
    • Construction of an in vitro bistable circuit from synthetic transcriptional switches
    • Kim, J., White, K. S., and Winfree, E. (2006) Construction of an in vitro bistable circuit from synthetic transcriptional switches. Mol. Syst. Biol. 2, 68.
    • (2006) Mol. Syst. Biol. , vol.2 , pp. 68
    • Kim, J.1    White, K.S.2    Winfree, E.3
  • 38
    • 79551599731 scopus 로고    scopus 로고
    • Synthetic in vitro transcriptional oscillators
    • Kim, J., and Winfree, E. (2011) Synthetic in vitro transcriptional oscillators. Mol. Syst. Biol. 7, 465.
    • (2011) Mol. Syst. Biol. , vol.7 , pp. 465
    • Kim, J.1    Winfree, E.2
  • 41
    • 0034632783 scopus 로고    scopus 로고
    • A DNA-fuelled molecular machine made of DNA
    • DOI 10.1038/35020524
    • Yurke, B., Turberfield, A., Mills, A., Jr, Simmel, F., and Neumann, J. (2000) A DNA-fuelled molecular machine made of DNA. Nature 406, 605-608. (Pubitemid 30641042)
    • (2000) Nature , vol.406 , Issue.6796 , pp. 605-608
    • Yurke, B.1    Turberfield, A.J.2    Mills Jr., A.P.3    Simmel, F.C.4    Neumann, J.L.5
  • 42
    • 0023198428 scopus 로고
    • Kinetic analysis of T7 RNA polymerase-promoter interactions with small synthetic promoters
    • DOI 10.1021/bi00384a006
    • Martin, C. T., and Coleman, J. E. (1987) Kinetic analysis of T7 RNA polymerase-promoter interactions with small synthetic promoters. Biochemistry 26, 2690-2696. (Pubitemid 17084639)
    • (1987) Biochemistry , vol.26 , Issue.10 , pp. 2690-2696
    • Martin, C.T.1    Coleman, J.E.2
  • 44
    • 72249110882 scopus 로고    scopus 로고
    • Control of DNA strand displacement kinetics using toehold exchange
    • Zhang, D. Y., and Winfree, E. (2009) Control of DNA strand displacement kinetics using toehold exchange. J. Am. Chem. Soc. 131, 17303-17314.
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 17303-17314
    • Zhang, D.Y.1    Winfree, E.2
  • 45
    • 0030735085 scopus 로고    scopus 로고
    • Cleavage of single strand RNA adjacent to RNA-DNA duplex regions by Escherichia coli RNase H1
    • DOI 10.1074/jbc.272.44.27513
    • Lima, W. F., and Crooke, S. T. (1997) Cleavage of single strand RNA adjacent to RNA-DNA duplex regions by Escherichia coli RNase H1. J. Biol. Chem. 272, 27513-27516. (Pubitemid 27473536)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.44 , pp. 27513-27516
    • Lima, W.F.1    Crooke, S.T.2
  • 46
    • 0037077311 scopus 로고    scopus 로고
    • Purification and characterization of the Escherichia coli exoribonuclease RNase R. Comparison with RNase II
    • DOI 10.1074/jbc.M202942200
    • Cheng, Z.-F., and Deutscher, M. P. (2002) Purification and characterization of the Escherichia coli exoribonuclease RNase R. J. Biol. Chem. 277, 21624-21629. (Pubitemid 34952311)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.24 , pp. 21624-21629
    • Cheng, Z.-F.1    Deutscher, M.P.2
  • 48
    • 0020373595 scopus 로고
    • Nucleic-acid junctions and lattices
    • Seeman, N. C. (1982) Nucleic-acid junctions and lattices. J. Theor. Biol. 99, 237-247.
    • (1982) J. Theor. Biol. , vol.99 , pp. 237-247
    • Seeman, N.C.1
  • 49
    • 0025635653 scopus 로고
    • De novo design of sequences for nucleic acid structural engineering
    • Seeman, N. C. (1990) De novo design of sequences for nucleic acid structural engineering. J. Biomol. Struct. Dyn. 8, 573-581.
    • (1990) J. Biomol. Struct. Dyn. , vol.8 , pp. 573-581
    • Seeman, N.C.1
  • 50
    • 0028924624 scopus 로고
    • Self-coded 3′-extension of run-off transcripts produces abberant products during in vitro transcription with T7 RNA polymerase
    • Triana-Alonso, F. J., Dabrowski, M., Wadzack, J., and Nierhaus, K. H. (1995) Self-coded 3′-extension of run-off transcripts produces abberant products during in vitro transcription with T7 RNA polymerase. J. Biol. Chem. 270, 6298-6307.
    • (1995) J. Biol. Chem. , vol.270 , pp. 6298-6307
    • Triana-Alonso, F.J.1    Dabrowski, M.2    Wadzack, J.3    Nierhaus, K.H.4
  • 51
    • 0037169502 scopus 로고    scopus 로고
    • Substitution of ribonucleotides in the T7 RNA polymerase promoter element
    • DOI 10.1074/jbc.M108820200
    • McGinness, K. E., and Joyce, G. F. (2002) Substitution of ribonucleotides in the T7 RNA polymerase promoter element. J. Biol. Chem. 277, 2987-2991. (Pubitemid 34953334)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.4 , pp. 2987-2991
    • McGinness, K.E.1    Joyce, G.F.2
  • 52
    • 0024819449 scopus 로고
    • Synthesis of small RNAs using T7 RNA polymerase
    • DOI 10.1016/0076-6879(89)80091-6
    • Milligan, J. F., and Uhlenbeck, O. C. (1989) Synthesis of small RNAs using T7 RNA polymerase. Methods Enzymol. 180, 51-62. (Pubitemid 20039565)
    • (1989) Methods in Enzymology , vol.180 , pp. 51-62
    • Milligan, J.F.1    Uhlenbeck, O.C.2
  • 53
    • 0023924749 scopus 로고
    • Processivity in early stages of transcription by T7 RNA polymerase
    • Martin, C. T., Muller, D. K., and Coleman, J. E. (1988) Processivity in early stages of transcription by T7 RNA polymerase. Biochemistry 27, 3966-3974.
    • (1988) Biochemistry , vol.27 , pp. 3966-3974
    • Martin, C.T.1    Muller, D.K.2    Coleman, J.E.3
  • 56
    • 33746207804 scopus 로고    scopus 로고
    • Secondary structure effects on DNA hybridization kinetics: A solution versus surface comparison
    • Gao, Y., Wolf, L. K., and Georgiadis, R. M. (2006) Secondary structure effects on DNA hybridization kinetics: A solution versus surface comparison. Nucleic Acids Res. 34, 3370-3377.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 3370-3377
    • Gao, Y.1    Wolf, L.K.2    Georgiadis, R.M.3
  • 58
    • 0030999232 scopus 로고    scopus 로고
    • Kinetic mechanism of transcription initiation by bacteriophage T7 RNA polymerase
    • DOI 10.1021/bi9630467
    • Jia, Y., and Patel, S. S. (1997) Kinetic mechanism of transcription initiation by bacteriophage T7 RNA polymerase. Biochemistry 36, 4223-4232. (Pubitemid 27171595)
    • (1997) Biochemistry , vol.36 , Issue.14 , pp. 4223-4232
    • Jia, Y.1    Patel, S.S.2
  • 59
    • 0036835759 scopus 로고    scopus 로고
    • Efficiencies of fluorescence resonance energy transfer and contact-mediated quenching in oligonucleotide probes
    • Marras, S. A. E., Kramer, F. R., and Tyagi, S. (2002) Efficiencies of fluorescence resonance energy transfer and contact-mediated quenching in oligonucleotide probes. Nucleic Acids Res. 30, e122.
    • (2002) Nucleic Acids Res. , vol.30
    • Marras, S.A.E.1    Kramer, F.R.2    Tyagi, S.3
  • 60
    • 42749109054 scopus 로고    scopus 로고
    • Statistical mechanical approaches to models with many poorly known parameters
    • Brown, K. S., and Sethna, J. P. (2003) Statistical mechanical approaches to models with many poorly known parameters. Phys. Rev. E 68, 021904.
    • (2003) Phys. Rev. E , vol.68 , pp. 021904
    • Brown, K.S.1    Sethna, J.P.2
  • 63
    • 84860899405 scopus 로고    scopus 로고
    • Bayesian design strategies for synthetic biology
    • Barnes, C. P., Silk, D., and Stumpf, M. P. H. (2011) Bayesian design strategies for synthetic biology. Interface Focus 1, 895-908.
    • (2011) Interface Focus , vol.1 , pp. 895-908
    • Barnes, C.P.1    Silk, D.2    Stumpf, M.P.H.3
  • 65
    • 0036693201 scopus 로고    scopus 로고
    • Chimeric RNA-DNA molecular beacon assay for ribonuclease H activity
    • Rizzo, J., Gifford, L. K., Zhang, X., Gewirtz, A. M., and Lu, P. (2002) Chimeric RNA-DNA molecular beacon assay for ribonuclease H activity. Mol. Cell. Probes 16, 277-283.
    • (2002) Mol. Cell. Probes , vol.16 , pp. 277-283
    • Rizzo, J.1    Gifford, L.K.2    Zhang, X.3    Gewirtz, A.M.4    Lu, P.5
  • 66
    • 84868223564 scopus 로고    scopus 로고
    • Synthetic networks
    • John Wiley & Sons, Ltd., New York
    • Kim, J. (2009) Synthetic networks. Automation in Proteomics and Genomics, pp 251-271, John Wiley & Sons, Ltd., New York.
    • (2009) Automation in Proteomics and Genomics , pp. 251-271
    • Kim, J.1
  • 67
    • 84855481443 scopus 로고    scopus 로고
    • Competition for catalytic resources alters biological network dynamics
    • Rondelez, Y. (2012) Competition for catalytic resources alters biological network dynamics. Phys. Rev. Lett. 108, 018102.
    • (2012) Phys. Rev. Lett. , vol.108 , pp. 018102
    • Rondelez, Y.1
  • 68
    • 35748931160 scopus 로고    scopus 로고
    • Data-based identifiability analysis of non-linear dynamical models
    • DOI 10.1093/bioinformatics/btm382
    • Hengl, S., Kreutz, C., Timmer, J., and Maiwald, T. (2007) Databased identifiability analysis of non-linear dynamical models. Bioinformatics 23, 2612-2618. (Pubitemid 350048365)
    • (2007) Bioinformatics , vol.23 , Issue.19 , pp. 2612-2618
    • Hengl, S.1    Kreutz, C.2    Timmer, J.3    Maiwald, T.4
  • 69
    • 0035910269 scopus 로고    scopus 로고
    • Pre-steady-state kinetics of initiation of transcription by T7 RNA polymerase: A new kinetic model
    • DOI 10.1006/jmbi.2000.4316
    • Kuzmine, I., and Martin, C. T. (2001) Pre-steady-state kinetics of initiation of transcription by T7 RNA polymerase: A new kinetic model. J. Mol. Biol. 305, 559-566. (Pubitemid 33032861)
    • (2001) Journal of Molecular Biology , vol.305 , Issue.3 , pp. 559-566
    • Kuzmine, I.1    Martin, C.T.2
  • 73
    • 84860912186 scopus 로고    scopus 로고
    • Inference in complex systems
    • Balding, D. (2011) Inference in complex systems. Interface Focus 1, 805-806.
    • (2011) Interface Focus , vol.1 , pp. 805-806
    • Balding, D.1
  • 74
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: A brief overview
    • DOI 10.1126/science.1069492
    • Kitano, H. (2002) Systems biology: A brief overview. Science 295, 1662-1664. (Pubitemid 34202893)
    • (2002) Science , vol.295 , Issue.5560 , pp. 1662-1664
    • Kitano, H.1
  • 75
    • 34247587012 scopus 로고    scopus 로고
    • Getting closer to the whole picture
    • DOI 10.1126/science.1142502
    • Sauer, U., Heinemann, M., and Zamboni, N. (2007) Getting closer to the whole picture. Science 316, 550-551. (Pubitemid 46683128)
    • (2007) Science , vol.316 , Issue.5824 , pp. 550-551
    • Sauer, U.1    Heinemann, M.2    Zamboni, N.3
  • 76
    • 33846017352 scopus 로고    scopus 로고
    • The nature of systems biology
    • DOI 10.1016/j.tim.2006.11.003, PII S0966842X06002642
    • Bruggeman, F. J., and Westerhoff, H. V. (2007) The nature of systems biology. Trends Microbiol. 15, 45-50. (Pubitemid 46043550)
    • (2007) Trends in Microbiology , vol.15 , Issue.1 , pp. 45-50
    • Bruggeman, F.J.1    Westerhoff, H.V.2
  • 77
    • 0842288337 scopus 로고    scopus 로고
    • Inferring cellular networks using probabilistic graphical models
    • DOI 10.1126/science.1094068
    • Friedman, N. (2004) Inferring cellular networks using probabilistic graphical models. Science 303, 799-805. (Pubitemid 38174650)
    • (2004) Science , vol.303 , Issue.5659 , pp. 799-805
    • Friedman, N.1
  • 78
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • DOI 10.1038/nrg1471
    • Kitano, H. (2004) Biological robustness. Nat. Rev. Genet. 5, 826-837. (Pubitemid 39457498)
    • (2004) Nature Reviews Genetics , vol.5 , Issue.11 , pp. 826-837
    • Kitano, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.