X-radiation inhibits histone deacetylase 1 and 2, upregulates Axin expression and induces apoptosis in non-small cell lung cancer

Radiation Oncology

Volumn 7, Issue 1, 2012, Pages

  Han, Yang ^a   Zhang, Yong ^a   Yang, Lian he ^a   Mi, Xiao yi ^a   Dai, Shun dong ^a   Li, Qing chang ^a   Xu, Hong tao ^a   Yu, Juan han ^a   Li, Guang ^a   Zhao, Jing ^a   Han, Chong ^a   Yuan, Xi ming ^b   Wang, En hua ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Axin; HDAC1; HDAC2; Lung neoplasm; Radiosensitization

Indexed keywords

AXIN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; SMALL INTERFERING RNA;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER STAGING; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; NICK END LABELING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; X RAY;

ADULT; AGED; APOPTOSIS; AXIN PROTEIN; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; FLOW CYTOMETRY; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; UP-REGULATION; X-RAYS;

EID: 84868238100     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-7-183     Document Type: Article

References (25)

1. Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T. Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells 1998, 3(6):395-403. 10.1046/j.1365-2443.1998.00198.x, 9734785.
2. Lustig B, Behrens J. The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol 2003, 129(4):199-221.
3. Huang CL, Liu D, Nakano J, Ishikawa S, Kontani K, Yokomise H, Ueno M. Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor-an expression in non-small-cell lung cancer. J Clin Oncol 2005, 23(34):8765-8773. 10.1200/JCO.2005.02.2871, 16314637.
4. Han Y, Wang Y, Xu HT, Yang LH, Wei Q, Liu Y, Zhang Y, Zhao Y, Dai SD, Miao Y, et al. X-radiation induces non-small-cell lung cancer apoptosis by upregulation of Axin expression. Int J Radiat Oncol Biol Phys 2009, 75(2):518-526. 10.1016/j.ijrobp.2009.05.040, 19735876.
5. Zupkovitz G, Tischler J, Posch M, Sadzak I, Ramsauer K, Egger G, Grausenburger R, Schweifer N, Chiocca S, Decker T, et al. Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol Cell Biol 2006, 26(21):7913-7928. 10.1128/MCB.01220-06, 1636735, 16940178.
6. Roth SY, Denu JM, Allis CD. Histone acetyltransferases. Annu Rev Biochem 2001, 70:81-120. 10.1146/annurev.biochem.70.1.81, 11395403.
7. Ng HH, Bird A. Histone deacetylases: silencers for hire. Trends Biochem Sci 2000, 25(3):121-126. 10.1016/S0968-0004(00)01551-6, 10694882.
8. Loidl P. Towards an understanding of the biological function of histone acetylation. FEBS Lett 1988, 227(2):91-95. 10.1016/0014-5793(88)80874-3, 3338575.
9. Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ, Thun MJ. Cancer statistics, 2004. CA Cancer J Clin 2004, 54(1):8-29. 10.3322/canjclin.54.1.8, 14974761.
10. Bradley J. A review of radiation dose escalation trials for non-small cell lung cancer within the radiation therapy oncology group. Semin Oncol 2005, 32(2 Suppl 3):S111-S113.
11. Rodrigues G, Lock M, D'Souza D, Yu E, Van Dyk J. Prediction of radiation pneumonitis by dose - volume histogram parameters in lung cancer-a systematic review. Radiother Oncol 2004, 71(2):127-138. 10.1016/j.radonc.2004.02.015, 15110445.
12. Kong FM, Hayman JA, Griffith KA, Kalemkerian GP, Arenberg D, Lyons S, Turrisi A, Lichter A, Fraass B, Eisbruch A, et al. Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): predictors for radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys 2006, 65(4):1075-1086. 10.1016/j.ijrobp.2006.01.051, 16647222.
13. Arrieta O, Villarreal-Garza C, Zamora J, Blake-Cerda M, de la Mata MD, Zavala DG, Muniz-Hernandez S, de la Garza J. Long-term survival in patients with non-small cell lung cancer and synchronous brain metastasis treated with whole-brain radiotherapy and thoracic chemoradiation. Radiat Oncol 2011, 6:166. 10.1186/1748-717X-6-166, 3235073, 22118497.
14. Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009, 324(5930):1076-1080. 10.1126/science.1164097, 2746744, 19461003.
15. Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, et al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 2009, 325(5945):1254-1257. 10.1126/science.1176709, 2850596, 19729656.
16. Yang XJ, Seto E. Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression. Curr Opin Genet Dev 2003, 13(2):143-153. 10.1016/S0959-437X(03)00015-7, 12672491.
17. Buchwald M, Kramer OH, Heinzel T. HDACi-targets beyond chromatin. Cancer Lett 2009, 280(2):160-167. 10.1016/j.canlet.2009.02.028, 19342155.
18. Ozawa A, Tanji N, Kikugawa T, Sasaki T, Yanagihara Y, Miura N, Yokoyama M. Inhibition of bladder tumour growth by histone deacetylase inhibitor. BJU Int 2010, 105(8):1181-1186. 10.1111/j.1464-410X.2009.08795.x, 19681894.
19. Jin KL, Pak JH, Park JY, Choi WH, Lee JY, Kim JH, Nam JH. Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues. J Gynecol Oncol 2008, 19(3):185-190. 10.3802/jgo.2008.19.3.185, 2676472, 19471575.
20. Zhang Z, Yamashita H, Toyama T, Sugiura H, Ando Y, Mita K, Hamaguchi M, Hara Y, Kobayashi S, Iwase H. Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*. Breast Cancer Res Treat 2005, 94(1):11-16. 10.1007/s10549-005-6001-1, 16172792.
21. Weichert W, Roske A, Gekeler V, Beckers T, Ebert MP, Pross M, Dietel M, Denkert C, Rocken C. Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol 2008, 9(2):139-148. 10.1016/S1470-2045(08)70004-4, 18207460.
22. Svechnikova I, Almqvist PM, Ekstrom TJ. HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. Int J Oncol 2008, 32(4):821-827.
23. Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 2001, 1(3):194-202. 10.1038/35106079, 11902574.
24. Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006, 5(9):769-784. 10.1038/nrd2133, 16955068.
25. Huang X, Gao L, Wang S, Lee CK, Ordentlich P, Liu B. HDAC inhibitor SNDX-275 induces apoptosis in erbB2-overexpressing breast cancer cells via down-regulation of erbB3 expression. Cancer Res 2009, 69(21):8403-8411. 10.1158/0008-5472.CAN-09-2146, 19826038.