Insulin and cardiovascular disease: Biomarker or association?

Diabetologia

Volumn 55, Issue 12, 2012, Pages 3145-3151

  Jandeleit Dahm, K A M ^a,b   Gray, S P ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Atherosclerosis; Cardiovascular disease; Insulin; Insulin resistance; Risk factors

Indexed keywords

BIOLOGICAL MARKER; GLUCOSE; INSULIN; INSULIN GLARGINE;

ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CORONARY ARTERY ATHEROSCLEROSIS; DIABETES MELLITUS; DISEASE ASSOCIATION; FOLLOW UP; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HEART INFARCTION; HUMAN; HYPERINSULINEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN LIKE ACTIVITY; INSULIN RESISTANCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR;

ATHEROSCLEROSIS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; PROINSULIN; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS;

EID: 84868208894     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2729-4     Document Type: Article

References (42)

1. Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M (1998) Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339:229-234
2. Nikkila EA, Miettinen TA, Vesenne MR, Pelkonen R (1965) Plasma-insulin in coronary heart-disease: response to oral and intravenous glucose and to tolbutamide. Lancet 2:508-511
3. Welborn TA, Wearne K (1979) Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care 2:154-160
4. Jarrett RJ, McCartney P, Keen H (1982) The Bedford Survey: ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabetics. Diabetologia 22:79-84
5. Pyorala K, Savolainen E, Kaukola S, Haapakoski J (1985) Plasma insulin as coronary heart disease risk factor: relationship to other risk factors and predictive value during 9 1/2-year follow-up of the Helsinki Policemen Study population. Acta Med Scand Suppl 701:38-52
6. Ducimetiere P, Eschwege E, Papoz L, Richard JL, Claude JR, Rosselin G (1980) Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population. Diabetologia 19:205-210
7. Reaven GM (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37:1595-1607
8. Stout RW (1969) Insulin and atherosclerosis. Lancet 2:327-328
9. Stout RW (1973) The role of insulin in the development of atherosclerosis. Adv Metab Disord 2(Suppl 2):41-47
10. Stout RW (1977) The relationship of abnormal circulating insulin levels to atherosclerosis. Atherosclerosis 27:1-13
11. Stout RW (1979) Diabetes and atherosclerosis-the role of insulin. Diabetologia 16:141-150
12. Stout RW (1981) The role of insulin in atherosclerosis in diabetics and nondiabetics: a review. Diabetes 30:54-57
13. Sarwar N, Sattar N, Gudnason V, Danesh J (2007) Circulating concentrations of insulin markers and coronary heart disease: a quantitative review of 19 Western prospective studies. Eur Heart J 28:2491-2497
14. O'Hare JP (1920) Glucose tolerance in chonic vascular hypertension. Am J Med 160:366-369
15. Major SG (1929) Blood pressure in diabetes mellitus: a statistical study. Arch Int Med 44:797-812
16. Fuller JH, Shipley MJ, Rose G, Jarrett RJ, Keen H (1980) Coronary-heart-disease risk and impaired glucose tolerance. The Whitehall study. Lancet 1:1373-1376
17. Kannel WB, McGee DL (1979) Diabetes and cardiovascular disease. The Framingham study. JAMA 241:2035-2038
18. Kannel WB, McGee DL (1979) Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study. Diabetes Care 2:120-126
19. Kannel WB, McGee DL (1979) Diabetes and cardiovascular risk factors: the Framingham study. Circulation 59:8-13
20. Cullen K, Stenhouse NS, Wearne KL, Welborn TA (1983) Multiple regression analysis of risk factors for cardiovascular disease and cancer mortality in Busselton, Western Australia-13-year study. J Chronic Dis 36:371-377
21. Sorge F, Schwartzkopff W, Neuhaus GA (1976) Insulin response to oral glucose in patients with a previous myocardial infarction and in patients with peripheral vascular disease. Hyperinsulinism and its relationships to hypertriglyceridemia and overweight. Diabetes 25:586-594
22. Santen RJ, Willis PW 3rd, Fajans SS (1972) Atherosclerosis in diabetes mellitus. Correlations with serum lipid levels, adiposity, and serum insulin level. Arch Intern Med 130:833-843
23. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR (1977) Diabetes, blood lipids, and the role of obesity in coronary heart disease risk for women. The Framingham study. Ann Intern Med 87:393-397
24. Pyorala K (1979) Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 2:131-141
25. Welin L, Eriksson H, Larsson B, Ohlson LO, Svardsudd K, Tibblin G (1992) Hyperinsulinaemia is not a major coronary risk factor in elderly men. The study of men born in 1913. Diabetologia 35:766-770
26. Hargreaves AD, Logan RL, Elton RA, Buchanan KD, Oliver MF, Riemersma RA (1992) Glucose tolerance, plasma insulin, HDL cholesterol and obesity: 12-year follow-up and development of coronary heart disease in Edinburgh men. Atherosclerosis 94:61-69
27. Liu QZ, Knowler WC, Nelson RG et al (1992) Insulin treatment, endogenous insulin concentration, and ECG abnormalities in diabetic Pima Indians. Cross-sectional and prospective analyses. Diabetes 41:1141-1150
28. Fontbonne A, Charles MA, Thibult N et al (1991) Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up. Diabetologia 34:356-361
29. Orchard TJ, Eichner J, Kuller LH, Becker DJ, McCallum LM, Grandits GA (1994) Insulin as a predictor of coronary heart disease: interaction with apolipoprotein E phenotype. A report from the Multiple Risk Factor Intervention Trial. Ann Epidemiol 4:40-45
30. Ferrannini E, Haffner SM, Mitchell BD, Stern MP (1991) Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia 34:416-422
31. Rubins HB, Robins SJ, Collins D et al (2002) Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT). Arch Intern Med 162:2597-2604
32. Ruige JB, Assendelft WJ, Dekker JM, Kostense PJ, Heine RJ, Bouter LM (1998) Insulin and risk of cardiovascular disease: a meta-analysis. Circulation 97:996-1001
33. Hu G, Qiao Q, Tuomilehto J, Eliasson M, Feskens EJ, Pyorala K (2004) Plasma insulin and cardiovascular mortality in non-diabetic European men and women: a meta-analysis of data from eleven prospective studies. Diabetologia 47:1245-1256
34. DeFronzo RA, Ferrannini E (1991) Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194
35. Park YM, Kashyap SR, Major JA, Silverstein RL (2012) Insulin promotes macrophage foam cell formation: potential implications in diabetes-related atherosclerosis. Lab Invest 92:1171-1180
36. Groop PH, Forsblom C, ThomasMC (2005)Mechanisms of disease: pathway-selective insulin resistance and microvascular complications of diabetes. Nat Clin Pract Endocrinol Metab 1:100-110
37. Jarrett RJ (1994) Why is insulin not a risk factor for coronary heart disease? Diabetologia 37:945-947
38. Mykkanen L, Laakso M, Pyorala K (1993) High plasma insulin level associated with coronary heart disease in the elderly. Am J Epidemiol 137:1190-1202
39. Gerstein HC, Bosch J, Dagenais GR et al (2012) Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med 367:319-328
40. Davies MJ, Metcalfe J, Gray IP, Day JL, Hales CN (1993) Insulin deficiency rather than hyperinsulinaemia in newly diagnosed type 2 diabetes mellitus. Diabet Med 10:305-312
41. Nagi DK, Hendra TJ, Ryle AJ et al (1990) The relationships of concentrations of insulin, intact proinsulin and 32-33 split proinsulin with cardiovascular risk factors in type 2 (non-insulin-dependent) diabetic subjects. Diabetologia 33:532-537
42. Haffner SM, Mykkanen L, Stern MP, Valdez RA, Heisserman JA, Bowsher RR (1993) Relationship of proinsulin and insulin to cardiovascular risk factors in nondiabetic subjects. Diabetes 42:1297-1302