Stroke and cancer: The importance of cancer-associated hypercoagulation as a possible stroke etiology

Stroke

Volumn 43, Issue 11, 2012, Pages 3029-3034

  Schwarzbach, Christopher J ^a   Schaefer, Anke ^a   Ebert, Anne ^a   Held, Valentin ^a   Bolognese, Manuel ^a   Kablau, Micha ^a   Hennerici, Michael G ^a   Fatar, Marc ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

cancer and stroke; coagulopathy; d dimer; embolic stroke; etiology; risk factors

Indexed keywords

D DIMER;

ADULT; AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; DEEP VEIN THROMBOSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LUNG CANCER; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; NEOPLASM; PANCREAS CANCER; PRIORITY JOURNAL;

FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; MALE; NEOPLASMS; STROKE; THROMBOPHILIA;

EID: 84868195365     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.112.658625     Document Type: Article

References (31)

1. Trouseau A. Phlegmasia Alba Dolens: Clinique Medicale de l-Hotel-Dieu de Paris. London, UK: New Sydenham Society; 1865:695-727.
2. Sutherland DE, Weitz IC, Liebman HA. Thromboembolic complications of cancer: epidemiology, pathogenesis, diagnosis, and treatment. Am J Hematol. 2003;72:43-52.
3. Varki A. Trouseau's syndrome: multiple definitions and multiple mechanisms. Blood. 2007;110:1723-1729.
4. Lee AY. Cancer and thromboembolic disease: pathogenic mechanisms. Cancer Treat Rev. 2002;28:137-140.
5. Dipasco PJ, Misra S, Koniaris LG, Moffat FL Jr. Thrombophilic state in cancer, part I: biology, incidence, and risk factors. J Surg Oncol. 2011;104:316-322.
6. Graus F, Rogers LR, Posner JB. Cerebrovascular complications in patients with cancer. Medicine (Baltimore). 1985;64:16-35.
7. Chaturvedi S, Ansell J, Recht L. Should cerebral ischemic events in cancer patients be considered a manifestation of hypercoagulability? Stroke. 1994;25:1215-1218.
8. Cestari DM, Weine DM, Panageas KS, Segal AZ, DeAngelis LM. Stroke in patients with cancer. Neurology. 2004;62:2025-2030.
9. Zhang YY, Cordato D, Shen Q, Sheng AZ, Hung WT, Chan DK. Risk factor, pattern, etiology and outcome in ischemic stroke patients with cancer: a nested case-control study. Cerebrovasc Dis. 2007;23:181-187.
10. Kwon HM, Kang BS, Yoon BW. Stroke as the first manifestation of concealed cancer. J Neurol Sci. 2007;258:80-83.
11. Hong CT, Tsai LK, Jeng JS. Patterns of acute cerebral infarcts in patients with active malignancy using diffusion-weighted imaging. Cerebrovasc Dis. 2009;28:411-416.
12. Oberndorfer S, Nussgruber V, Berger O, Lahrmann H, Grisold W. Stroke in cancer patients: a risk factor analysis. J Neurooncol. 2009;94:221-226.
13. Kim SG, Hong JM, Kim HY, Lee J, Chung PW, Park KY, et al. Ischemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea. Stroke. 2010;41:798-801.
14. Seok JM, Kim SG, Kim JW, Chung CS, Kim GM, Lee KH, et al. Coagulopathy and embolic signal in cancer patients with ischemic stroke. Ann Neurol. 2010;68:213-219.
15. Bang OY, Seok JM, Kim SG, Hong JM, Kim HY, Lee J, et al. Ischemic stroke and cancer: stroke severely impacts cancer patients, while cancer increases the number of strokes. J Clin Neurol. 2011;7:53-59.
16. Robert Koch-Institut und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V. In: Husmann G, Kaatsch P, Katalinic A, Bertz J, Haberland J, Kraywinkel K, Wolf U, editors. Krebs in Deutschland 2005/2006. Häufigkeiten und Trends.7th ed. Berlin: Robert Koch-Institut und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V.; 2010.
17. Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27:502-508.
18. Wolf ME, Sauer T, Alonso A, Hennerici MG. Comparison of the new ASCO classification with the TOAST classification in a population with acute ischemic stroke. J Neurol. 2012;259:1284-1289.
19. Nguyen T, DeAngelis LM. Stroke in cancer patients. Curr Neurol Neurosci Rep. 2006;6:187-192.
20. Grisold W, Oberndorfer S, Struhal W. Stroke and cancer: a review. Acta Neurol Scand. 2009;119:1-16.
21. Rogers LR. Cerebrovascular complications in patients with cancer. Semin Neurol. 2004;24:453-460.
22. Young A, Chapman O, Connor C, Poole C, Rose P, Kakkar AK. Thrombosis and cancer. Nat Rev Clin Oncol. 2012;9:437-449.
23. Bick RL. Cancer-associated thrombosis N Engl J Med. 2003;349: 109-111.
24. Tripodi A. d-dimer testing in laboratory practice. Clin Chem. 2011;57:1256-1262.
25. Hejna M, Raderer M, Zielinski CC. Inhibition of metastases by anticoagulants. J Natl Cancer Inst. 1999;91:22-36.
26. Baird AE, Lövblad KO, Schlaug G, Edelman RR, Warach S. Multiple acute stroke syndrome: marker of embolic disease? Neurology. 2000;54:674-678.
27. Chen PC, Muo CH, Lee YT, Yu YH, Sung FC. Lung cancer and incidence of stroke: a population-based cohort study. Stroke. 2011;42:3034-3039.
28. Sack GH Jr, Levin J, Bell WR. Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore). 1977;56:1-37.
29. Lieberman JS, Borrero J, Urdoncta E, Wright IS. Thrombophlebitis and cancer. JAMA. 1961;177:542-545.
30. Rickles FR, Levine MN. Epidemiology of thrombosis in cancer. Acta Haematol. 2001;106:6-12.
31. Horowitz N, Brenner B. Thrombophilia and cancer. Pathophysiol Haemost Thromb. 2008;36:131-136.