Role of neurotrophins in the development and function of neural circuits that regulate energy homeostasis

Journal of Molecular Neuroscience

Volumn 48, Issue 3, 2012, Pages 654-659

  Fargali, Samira ^a   Sadahiro, Masato ^a   Jiang, Cheng ^a   Frick, Amy L ^a   Indall, Tricia ^a   Cogliani, Valeria ^a   Welagen, Jelle ^a   Lin, Wei Jye ^a   Salton, Stephen R ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Brain derived neurotrophic factor (BDNF); Corticotropin releasing hormone (CRH); Hypothalamus; Nerve growth factor (NGF); Neurotrophin; VGF

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID; GROWTH FACTOR; NEUROPEPTIDE; NEUROTROPHIC GROWTH FACTOR; NEUROTROPHIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; ENERGY BALANCE; HOMEOSTASIS; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PERIPHERAL NERVOUS SYSTEM;

ADIPOSE TISSUE; ANIMALS; AUTONOMIC FIBERS, POSTGANGLIONIC; BASAL METABOLISM; BRAIN STEM; CORTICOTROPIN-RELEASING HORMONE; EATING; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HOMEOSTASIS; HUMANS; HYPOTHALAMUS; NERVE GROWTH FACTORS; NEURAL PATHWAYS; NEUROPEPTIDES; RECEPTORS, NERVE GROWTH FACTOR; SIGNAL TRANSDUCTION; SPINAL CORD; SYMPATHETIC NERVOUS SYSTEM;

EID: 84868193688     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9790-9     Document Type: Article

References (51)

1. ACTS (1996) A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology 46:1244-1249
2. Allen TL, Matthews VB, Febbraio MA (2011) Overcoming insulin resistance with ciliary neurotrophic factor. Handb Exp Pharmacol (203):179-199
3. Bariohay B, Lebrun B, Moyse E, Jean A (2005) Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex. Endocrinology 146:5612-5620 (Pubitemid 41653078)
4. Bariohay B, Roux J, Tardivel C, Trouslard J, Jean A, Lebrun B (2009) Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control. Endocrinology 150:2646-2653
5. Bartolomucci A, Possenti R, Mahata SK, Fischer-Colbrie R, Loh YP, Salton SR (2011) The extended granin family: structure, function, and biomedical implications. Endocr Rev 32:755-797
6. Bozdagi O, Rich E, Tronel S et al (2008) The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism. J Neurosci 28:9857-9869
7. Cao L, Choi EY, Liu X et al (2011) White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis. Cell Metab 14:324-338
8. Chaldakov GN, Tonchev AB, Aloe L (2009) NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. Riv Psichiatr 44:79-87
9. Collins S, Cao W, Robidoux J (2004) Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol Endocrinol 18:2123-2131 (Pubitemid 39215245)
10. Dallman MF, la Fleur SE, Pecoraro NC, Gomez F, Houshyar H, Akana SF (2004) Minireview: Glucocorticoids - food intake, abdominal obesity, and wealthy nations in 2004. Endocrinology 145:2633- 2638 (Pubitemid 38686208)
11. Glebova NO, Ginty DD (2004) Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci 24:743-751 (Pubitemid 38166500)
12. Glebova NO, Ginty DD (2005) Growth and survival signals controlling sympathetic nervous system development. Annu Rev Neurosci 28:191-222 (Pubitemid 41098904)
13. Hahm S, Mizuno TM, Wu TJ et al (1999) Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron 23:537- 548 (Pubitemid 29359924)
14. Hahm S, Fekete C, Mizuno TM et al (2002) VGF is required for obesity induced by diet, gold thioglucose treatment and agouti, and is differentially regulated in POMC- and NPY-containing arcuate neurons in response to fasting. J Neurosci 22:6929-6938 (Pubitemid 35379151)
15. Harrington AW, St Hillaire C, Zweifel LS et al (2011) Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. Cell 146:421-434
16. Holtmann B, Wiese S, Samsam M et al (2005) Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function. J Neurosci 25:1778-1787 (Pubitemid 40279283)
17. Honma Y, Araki T, Gianino S et al (2002) Artemin is a vascularderived neurotropic factor for developing sympathetic neurons. Neuron 35:267-282 (Pubitemid 34876730)
18. Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736 (Pubitemid 32695243)
19. Jeanneteau FD, Lambert WM, Ismaili N et al (2012) BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A 109:1305-1310
20. Kernie SG, Liebl DJ, Parada LF (2000) BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19:1290-1300 (Pubitemid 30151025)
21. Kokoeva MV, Yin H, Flier JS (2005) Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 310:679-683 (Pubitemid 41528161)
22. Kuruvilla R, Zweifel LS, Glebova NO et al (2004) A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell 118:243-255 (Pubitemid 38962579)
23. Lapchak PA, Hefti F (1992) BDNF and NGF treatment in lesioned rats: effects on cholinergic function and weight gain. Neuroreport 3:405-408
24. Levi A, Eldridge JD, Paterson BM (1985) Molecular cloning of a gene sequence regulated by nerve growth factor. Science 229:393-395 (Pubitemid 15073084)
25. Levi A, Ferri GL, Watson E, Possenti R, Salton SR (2004) Processing, distribution and function of VGF, a neuronal and endocrine peptide precursor. Cell Mol Neurobiol 24:517-533 (Pubitemid 38988061)
26. Levin BE (2007) Neurotrophism and energy homeostasis: perfect together. Am J Physiol Regul Integr Comp Physiol 293:R988-R991 (Pubitemid 47364640)
27. Liao GY, An JJ, Gharami K et al (2012) Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin. Nat Med 18:564-571
28. Matthews VB, Febbraio MA (2008) CNTF: a target therapeutic for obesity-related metabolic disease? J Mol Med (Berl) 86:353-361
29. Miller RG, Petajan JH, Bryan WW et al (1996) A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group. Ann Neurol 39:256-260 (Pubitemid 26071576)
30. Nakagawa T, Tsuchida A, Itakura Y et al (2000) Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 49:436-444 (Pubitemid 30131790)
31. Noble EE, Billington CJ, Kotz CM, Wang C (2011) The lighter side of BDNF. Am J Physiol Regul Integr Comp Physiol 300:R1053- R1069
32. Pelleymounter MA, Cullen MJ, Wellman CL (1995) Characteristics of BDNF-induced weight loss. Exp Neurol 131:229-238
33. Possenti R, Muccioli G, Petrocchi P et al (2012) Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGFderived peptide TLQP-21. Biochem J 441:511-522
34. Rios M, Fan G, Fekete C et al (2001) Conditional deletion of brainderived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15:1748-1757 (Pubitemid 32939305)
35. Seeley RJ (2005) More neurons, less weight. Nat Med 11:1276-1278 (Pubitemid 41752900)
36. Singh KK, Park KJ, Hong EJ et al (2008) Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci 11:649-658 (Pubitemid 351748111)
37. Suwa M, Kishimoto H, Nofuji Y et al (2006) Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. Metabolism 55:852-857 (Pubitemid 43902888)
38. Tapia-Arancibia L, Rage F, Givalois L, Arancibia S (2004) Physiology of BDNF: focus on hypothalamic function. Front Neuroendocrinol 25:77-107 (Pubitemid 39582717)
39. Thakker-Varia S, Krol JJ, Nettleton J et al (2007) The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus. J Neurosci 27:12156-12167 (Pubitemid 350085466)
40. Toriya M, Maekawa F, Maejima Y et al (2010) Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus. J Neuroendocrinol 22:987-995
41. Toshinai K, Yamaguchi H, Kageyama H et al (2010) Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus. Am J Physiol Endocrinol Metab 299:E394-E401
42. Tsuchida A, Nakagawa T, Itakura Y et al (2001) The effects of brainderived neurotrophic factor on insulin signal transduction in the liver of diabetic mice. Diabetologia 44:555-566 (Pubitemid 32411271)
43. Tsuchida A, Nonomura T, Nakagawa T et al (2002) Brain-derived neurotrophic factor ameliorates lipid metabolism in diabetic mice. Diabetes Obes Metab 4:262-269 (Pubitemid 34814867)
44. Turtzo LC, Marx R, Lane MD (2001) Cross-talk between sympathetic neurons and adipocytes in coculture. Proc Natl Acad Sci U S A 98:12385-12390 (Pubitemid 33019955)
45. Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M (2007) Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 27:14265-14274
46. Wang C, Bomberg E, Levine A, Billington C, Kotz CM (2007a) Brainderived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake. Am J Physiol Regul Integr Comp Physiol 293:R1037-R1045 (Pubitemid 47358922)
47. Wang C, Bomberg E, Billington C, Levine A, Kotz CM (2007b) Brainderived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intake. Am J Physiol Regul Integr Comp Physiol 293:R1003-R1012 (Pubitemid 47358918)
48. Wang C, Bomberg E, Billington C, Levine A, Kotz CM (2007c) Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate. Am J Physiol Regul Integr Comp Physiol 293:R992-R1002 (Pubitemid 47358917)
49. Watson E, Hahm S, Mizuno TM et al (2005) VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology 146:5151-5163 (Pubitemid 41653029)
50. Watson E, Fargali S, Okamoto H et al (2009) Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure. BMC Physiol 9:19
51. Xu B, Goulding EH, Zang K et al (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6:736-742 (Pubitemid 36792889)