Alcohol handrubbing and chlorhexidine handwashing protocols for routine hospital practice: A randomized clinical trial of protocol efficacy and time effectiveness

American Journal of Infection Control

Volumn 40, Issue 9, 2012, Pages 800-805

  Chow, Angela ^a,b,c   Arah, Onyebuchi A ^a,d   Chan, Siew Pang ^e,f,g   Poh, Bee Fong ^b   Krishnan, Prabha ^b   Ng, Woei Kian ^b   Choudhury, Saugata ^b   Chan, Joey ^h   Ang, Brenda ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TAN TOCK SENG HOSPITAL   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e LA TROBE UNIVERSITY   (Australia)

^f Australian Institute for Primary Care and Ageing   (Australia)

^g Stata Users Group   (Singapore)

^h KHOO TECK PUAT HOSPITAL   (Singapore)

Author keywords

Alcohol handrub; Hand hygiene; Health care associated infection; Infection control; Patient care

Indexed keywords

ALCOHOL HANDRUB; CHLORHEXIDINE GLUCONATE; DISINFECTANT AGENT; MICROSHIELD 4; MICROSHIELD HANDRUB; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL LOAD; CLINICAL PRACTICE; CLINICAL PROTOCOL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HAND WASHING; HOSPITAL PATIENT; HUMAN; MEDICAL STAFF; MICROBIOLOGICAL EXAMINATION; NURSING STAFF; PATIENT CARE; PERSONAL HYGIENE; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TERTIARY HEALTH CARE; WARD;

ALCOHOLS; BACTERIA; BACTERIAL LOAD; CHLORHEXIDINE; DISINFECTANTS; HAND; HAND DISINFECTION; HOSPITALS; HUMANS; INFECTION CONTROL; TREATMENT OUTCOME;

EID: 84868191079     PISSN: 01966553     EISSN: 15273296     Source Type: Journal    
DOI: 10.1016/j.ajic.2011.10.005     Document Type: Article

References (23)

1. D.J. Weber, W.A. Rutala, M.B. Miller, K. Huslage, and E. Sickbert-Bennett Role of hospital surfaces in the transmission of emerging health care-associated pathogens: norovirus, Clostridium difficile, and Acinetobacter species Am J Infect Control 38 5 Suppl 1 2010 S25 S33
2. D. Pittet, S. Dharan, S. Touveneau, V. Sauvan, and T.V. Perneger Bacterial contamination of the hands of hospital staff during routine patient care Arch Intern Med 159 1999 821 826 (Pubitemid 29200308)
3. A. Benning, M. Dixon-Woods, U. Nwulu, M. Ghaleb, J. Dawson, and N. Barber Multiple component patient safety intervention in English hospitals: controlled evaluation of second phase BMJ 342 2011 d199
4. World Health Organization (WHO) WHO guidelines on hand hygiene in health care. First global patient safety challenge: clean care is safer case 2009 WHO Geneva
5. D. Pittet, and J. Boyce Hand hygiene during patient care: pursuing the Semmelweis legacy Lancet Infect Dis 1 2001 9 20
6. D. Pittet, S. Hugonnet, S. Harbarth, P. Monronga, V. Sauvan, and S. Touveneau Effectiveness of a hospital-wide programme to improve compliance with hand hygiene Lancet 356 2000 1307 1312
7. D. Pittet Improving compliance with hand hygiene in hospitals Infect Control Hosp Epidemiol 21 2000 381 386
8. S. Harbarth, P. Sudre, S. Dharan, M. Cadenas, and D. Pittet Outbreak of Enterobacter cloacae related to understaffing, overcrowding, and poor hygiene practices Infect Control Hosp Epidemiol 20 1999 598 603
9. G. Kampf, H. Löffler, and P. Gastmeier Hand hygiene for the prevention of nosocomial infections Dtsch Arztebl Int 106 2009 649 655 Epub October 2, 2009
10. B. Allegranzi, and D. Pttet Role of hand hygiene in healthcare-associated infection prevention J Hosp Infect 73 2009 305 315 Epub August 31, 2009
11. J.M. Boyce Scientific basis for handwashing with alcohol and other waterless antiseptic agents W.A. Rutala, Disinfection, sterilization and antisepsis: principles and practices in healthcare facilities 2001 Association for Professionals in Infection Control and Epidemiology Washington [DC] p. 140-151
12. E. Girou, S. Loyeau, P. Legrand, F. Oppein, and C. Brun-Buisson Efficacy of handrubbing with alcohol based solution versus standard handwashing with antiseptic soap: randomised clinical trial BMJ 325 2002 362
13. M. Zaragoza, M. Sallés, J. Gomez, J.M. Bayas, and A. Trilla Handwashing with soap or alcoholic solutions? A randomized clinical trial of its effectiveness Am J Infect Control 27 1999 258 261 (Pubitemid 29277955)
14. J.M. Boyce, and D. Pittet Guideline for hand hygiene in health-care settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force MMWR Recomm Rep 51 RR16 2002 1 45
15. A.F. Widmer, M. Conzelmann, M. Tomic, R. Frei, and A.M. Stranden Introducing alcohol-based hand rub for hand hygiene: the critical need for training Infect Control Hosp Epidemiol 28 2007 50 54 Epub December 29, 2006 (Pubitemid 46219225)
16. G. Kampf, M. Reichel, Y. Feil, S. Eggerstedt, and P.M. Kaulfers Influence of rub-in technique on required application time and hand coverage in hygienic hand disinfection BMC Infect Dis 8 2008 149
17. P.A. Wayne Performance standards for antimicrobial susceptibility testing: eighteenth informational supplement. Document M100-S18 2008 Clinical and Laboratory Standards Institute Wayne [PA]
18. K.Y. Liang, and S.L. Zeger Longitudinal data analysis using generalized linear models Biometrika 73 1986 13 22
19. S.L. Zeger, K.Y. Liang, and P.S. Albert Models for longitudinal data: a generalized estimating equation approach Biometrics 44 1988 1049 1060 (Pubitemid 19026037)
20. G.M. Fitzmaurice, N.M. Laird, and J.H. Ware Applied longitudinal analysis 2004 Wiley New York [NY] p. 441-66
21. A. Voss, and A.F. Widmer No time for handwashing? Handwashing versus alcoholic rub: can we afford 100% compliance? Infect Control Hosp Epidemiol 18 1997 205 208 (Pubitemid 127469875)
22. A.F. Widmer Replace hand washing with use of a waterless alcohol hand rub? Clin Infect Dis 31 2000 136 143 (Pubitemid 32268953)
23. J.C. Lucet, M.P. Rigaud, F. Mentre, N. Kassis, C. Deblangy, and A. Andremont Hand contamination before and after different hand hygiene techniques: a randomized clinical trial J Hosp Infect 50 2002 276 280 (Pubitemid 37554855)