Suppression of immune responses in pigs by nonstructural protein 1 of porcine reproductive and respiratory syndrome virus

Canadian Journal of Veterinary Research

Volumn 76, Issue 4, 2012, Pages 255-260

  Zhou, Yefei ^b   Bai, Juan ^a   Li, Yufeng ^a   Wang, Xinglong ^a   Wang, Xianwei ^a   Jiang, Ping ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

^b NANJING XIAOZHUANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN; GLYCOPROTEIN GP 5; INTERLEUKIN 10; NONSTRUCTURAL PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTERIVIRUS; ARTICLE; HUMORAL IMMUNITY; IN VITRO STUDY; NONHUMAN; PESTIVIRUS; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; SWINE;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, VIRAL; FEMALE; GENETIC VECTORS; INTERFERON-GAMMA; INTERLEUKIN-10; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; RECOMBINANT PROTEINS; SWINE; VACCINATION; VIRAL NONSTRUCTURAL PROTEINS;

ADENOVIRIDAE; CLASSICAL SWINE FEVER VIRUS; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE; SUS;

EID: 84868145180     PISSN: 08309000     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Bennfield DA, Nelson E, Collins JE, et al. Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332). J Vet Diagn Invest 1992;4:127-133.
2. Wensvoort G, Terpstra C, Pol JMA, et al. Mystery swine disease in the Netherlands: The isolation of Lelystad virus. Vet Q 1991;13:121-130.
3. Gorbalenya AE, Enjuanes L, Ziebuhr J, Snijder EJ. Evolving the largest RNA virus genome. Virus Res 2006;117:17-37.
4. Miller LC, Laegreid WW, Bono JL, Chitko-McKown CG, Fox JM. Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells. Arch Virol 2004;149:2453-2463.
5. Miller LC, Lager KM, Kehrli ME. Role of Toll-like receptors in activation of porcine alveolar macrophages by porcine reproductive and respiratory syndrome virus. Clin Vaccine Immunol 2009;16:360-365.
6. Li Y, Wang X, Bo K, et al. Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the mid-eastern region of China. Vet J 2007;174:577-584.
7. Tian K, Yu X, Zhao T, et al. Emergence of fatal PRRSV variants: Unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS ONE 2007;2:1-10.
8. Conzelmann KK, Visser N, Van Woensel P, Thiel HJ. Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group. Virology 1993; 193:329-339.
9. Bruce CB, Akrigg A, Sharpe SA, Hanke T, Wilkinson GWG, Cranage M P. Replication-deficient recombinant adenoviruses expressing the human immunodeficiency virus Env antigen can induce both humoral and CTL immune responses in mice. J Gen Virol 1999;80:2621-2628.
10. Wu HW, Fang Y, Rowland RR, et al. The 2b protein as a minor structural component of PRRSV. Virus Res 2005;114:177-181.
11. Bautista EM, Faaberg KS, Mickelson D, McGruder ED. Functional properties of the predicted helicase of porcine reproductive and respiratory syndrome virus. Virology 2002;298:258-270.
12. Meulenberg JJ, Hulst MM, de Meijer EJ, et al. Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV. Virology 1993;192:62-72.
13. Snijder EJ, Meulenberg JJM. The molecular biology of arterivi- ruses. J Gen Virol 1998;79:961-979.
14. Nelsen CJ, Murtaugh MP, Faaberg KS. Porcine reproductive and respiratory syndrome virus comparison: Divergent evolution on two continents. J Virol 1999;73:270-280.
15. Van Aken D, Zevenhoven-Dobbe J, Gorbalenya AE, Snijder EJ. Proteolytic maturation of replicase polyprotein pp1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7. J Gen Virol 2006;87:3473-3482.
16. Wootton S, Yoo D, Rogan D. Full-length sequence of a Canadian porcine reproductive and respiratory syndrome virus (PRRSV) isolate. Arch Virol 2000;145:2297-2323.
17. Ziebuhr J, Snijder EJ, Gorbalenya AE. Virus-encoded protein- ases and proteolytic processing in the Nidovirales. J Gen Virol 2000;81:853-879.
18. Chen Z, Lawson S, Sun Z, et al. Identification of two auto- cleavage products of nonstructural protein 1 (NSP1) in porcine reproductive and respiratory syndrome virus infected cells: NSP1 function as interferon antagonist. Virology 2010;398:87-97.
19. Overend C, Mitchell R, He D, Rompato G, Grubman MJ, Garmendia AE. Recombinant swine beta interferon protects swine alveolar macrophages and MARC-145 cells from infection with Porcine reproductive and respiratory syndrome virus. J Gen Virol 2007;88:925-931.
20. Turner J, Gonzalez-Juarrero M, Ellis DL, et al. In vivo IL-10 pro- duction reactivates chronic pulmonary tuberculosis in C57BL/6 mice. J Immunol 2002;169:6343-6351.
21. Charerntantanakul W, Platt R, Roth JA. Effects of porcine reproductive and respiratory syndrome virus-infected antigen- presenting cells on T cell activation and antiviral cytokine pro- duction. Viral Immunol 2006;19:646-661.
22. Díaz I, Darwich L, Pappaterra G, Pujols J, Mateu E. Different European-type vaccines against porcine reproductive and respiratory syndrome virus have different immunological properties and confer different protection to pigs. Virology 2006;351:249-259.
23. Moennig V. Introduction to classical swine fever virus, disease and control policy. Vet Microbiol 2000;73:93-102.
24. Van Oirschot JT. Vaccinology of classical swine fever: From lab to field. Vet Microbiol 2003;96:367-384.
25. Li H, Yang H. Infection of porcine reproductive and respiratory syndrome virus suppresses the antibody response to classical swine fever virus vaccination. Vet Microbiol 2003;95:295-301.
26. Brown E, Lawson S, Welbon C, et al. Antibody response to porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural proteins and implications for diagnostic detection and differentiation of PRRSV types I and II. Clin Vaccine Immunol 2009;16:628-635.
27. Johnson CR, Yu W, Murtaugh MP. Cross-reactive antibody responses to NSP1 and NSP2 of porcine reproductive and respiratory syndrome virus. J Gen Virol 2007;88:1184-1195.
28. Fang Y, Snijder EJ. The PRRSV replicase: Exploring the multi- functionality of an intriguing set of nonstructural proteins. Virus Res 2010;154:61-76.
29. Beura LK, Sarkar SN, Kwon B, et al. Porcine reproductive and respiratory syndrome virus nonstructural protein 1b modulates host innate immune response by antagonizing IRF3 activation. J Virol 2010;84:1574-1584.
30. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 1998;95:2509-2514.
31. Jiang W, Jiang P, Li Y, Tang J, Wang X, Ma S. Recombinant adeno- virus expressing GP5 and M fusion proteins of porcine reproductive and respiratory syndrome virus induce both humoral and cell-mediated immune responses in mice. Vet Immunol Immunopathol 2006;113:169-180.
32. Qiu HJ, Tian ZJ, Tong GZ, Zhou YJ, Ni JQ, Luo YZ. Protective immunity induced by a recombinant pseudorabies virus expressing the GP5 of porcine reproductive and respiratory syndrome virus in piglets. Vet Immunol Immunopathol 2005;106:309-319.
33. Council for International Organizations of Medical Sciences. International Guiding Principles for Biomedical Research Involving Animals (1985). Available from http://cioms.ch/publications/guidelines/1985_texts_of_guidelines.htm Last accessed July 16, 2012.
34. Mateu E, Diaz I. The challenge of PRRS immunology. Vet J 2008;177:345-351.
35. Xiao Z, Batista L, Dee S, Halbur P, Murtaugh MP. The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load. J Virol 2004;78:5923-5933.
36. Meier WA, Galeota J, Osorio FA, Husmann RJ, Schnitzlein WM, Zuckermann FA. Gradual development of the interferon-g response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination. Virology 2003;309:18-31.
37. Kroese MV, Zevenhoven-Dobbe JC, Bos-de Ruijter JN, et al. The NSP1 a and nsp1 papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis. J Gen Virol 2008;89:494-499.
38. Batista L, Pijoan C, Dee S, et al. Virological and immunological responses to porcine reproductive and respiratory syndrome virus in a large population of gilts. Can J Vet Res 2004;68: 267-273.
39. high cells. Vet Res 2009;40:46.
40. Suradhat S, Kesdangsakonwut S, Sada W, Buranapraditkun S, Wongsawang S, Thanawongnuwech R. Negative impact of porcine reproductive and respiratory syndrome virus infection on the efficacy of classical swine fever vaccine. Vaccine 2006;24:2634-2642.
41. Charerntantanakul W, Platt R, Johnson W, Roof M, Vaughn E, Roth JA. Immune responses and protection by vaccine and various vaccine adjuvant candidates to virulent porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol 2006;109:99-115.
42. Bastos RG, Dellagostin OA, Barletta RG, et al. Immune response of pigs inoculated with Mycobacterium bovis BCG expressing a truncated form of GP5 and M protein of porcine reproductive and respiratory syndrome virus. Vaccine 2004;22:467-474.
43. Cao J, Wang XL, Du YJ, Li YF, Wang XW, Jiang P. CD40 ligand expressed in adenovirus can improve the immunogenicity of the GP3 and GP5 of porcine reproductive and respiratory syndrome virus in swine. Vaccine 2010;28:7514-7522.
44. Pirzadeh B, Dea S. Immune response in pigs vaccinated with plasmid DNA encoding ORF5 of porcine reproductive and respiratory syndrome virus. J Gen Virol 1998;79:989-999.
45. Jiang WM, Jiang P, Wang XL, Li YF, Wang XW, Du YJ. Influence of porcine reproductive and respiratory syndrome virus GP5 glycoprotein N-linked glycans on immune responses in mice. Virus Genes 2007;35:663-671.