Ultrastructural and clinical evidence of subretinal debris accumulation in type 2 macular telangiectasia

British Journal of Ophthalmology

Volumn 96, Issue 11, 2012, Pages 1404-1409

  Cherepanoff, Svetlana ^a,b   Killingsworth, Murray C ^b,c   Zhu, Meidong ^d   Nolan, Timothy ^e,f   Hunyor, Alex P ^d,g   Young, Stephanie H ^h   Hageman, Gregory S ⁱ   Gillies, Mark C ^d,g  

^a PRINCE OF WALES HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c LIVERPOOL HOSPITAL   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e ST VINCENT S HOSPITAL   (Australia)

^f BANKSTOWN LIDCOMBE HOSPITAL   (Australia)

^g Repatriation General Hospital ^*

^h Department of Microbiology and Infectious Diseases   (Australia)

ⁱ UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTOFLUORESCENCE IMAGING; BIOACCUMULATION; DIGITAL IMAGING; EYE EXAMINATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MACULAR TELANGIECTASIA TYPE 2; MAJOR CLINICAL STUDY; MALE; MUELLER CELL; OPTICAL COHERENCE TOMOGRAPHY; PHENOTYPE; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA DISEASE; RETINA MACULOPATHY; SUBRETINAL DEBRIS; TELANGIECTASIA; TRANSMISSION ELECTRON MICROSCOPY; VISUAL ACUITY;

AGED; DIAGNOSIS, DIFFERENTIAL; FLUORESCEIN ANGIOGRAPHY; FUNDUS OCULI; HUMANS; MALE; MICROSCOPY, ELECTRON; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL ROD PHOTORECEPTOR CELLS; RETINAL TELANGIECTASIS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84868144161     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjophthalmol-2011-301009     Document Type: Article

References (17)

1. Yannuzzi LA, Bardal AMC, Freund KB, et al. Idiopathic macular telangiectasia. Arch Ophthalmol 2006;124:450-60.
2. Gass JD, Blodi BA. Idiopathic juxtafoveolar retinal telangiectasis. Update of classification and follow-up study. Ophthalmology 1993;100:1536-46.
3. Gaudric A, Ducos de Lahitte G, Cohen SY, et al. Optical coherence tomography in group 2A idiopathic juxtafoveolar retinal telangiectasis. Arch Ophthalmol 2006;124:1410-19.
4. Klein R, Blodi BA, Meuer SM, et al. The prevalence of macular telangiectasia type 2 in the Beaver Dam eye study. Am J Ophthalmol 2010;150:55-62.e2.
5. Green WR, Quigley HA, De la Cruz Z, et al. Parafoveal retinal telangiectasis. Light and electron microscopy studies. Trans Ophthalmol Soc UK 1980;100:162-70.
6. Powner MB, Gillies MC, Tretiach M, et al. Perifoveal muller cell depletion in a case of macular telangiectasia type 2. Ophthalmology 2010;117:2407-16.
7. Clemons TE, Gillies MC, Chew EY, et al. Baseline characteristics of participants in the natural history study of macular telangiectasia (MacTel) MacTel Project Report No. 2. Ophthalmic Epidemiol 2010;17:66-73.
8. Gass JDM. Retinal capillary diseases. Stereoscopic atlas of macular diseases: diagnosis and treatment, 4th edn. St Louis, MO: Mosby Year Book Inc, 1997:506-11.
9. Arnold JJ, Sarks JP, Killingsworth MC, et al. Adult vitelliform macular degeneration: a clinicopathological study. Eye 2003;17:717-26.
10. Dyer MA, Cepko CL. Control of Müller glial cell proliferation and activation following retinal injury. Nat Neurosci 2000;3:873-80.
11. MacLaren RE. Development and role of retinal glia in regeneration of ganglion cells following retinal injury. Br J Ophthalmol 1996;80:458-64.
12. Nork TM, Wallow IH, Sramek SJ, et al. Muller's cell involvement in proliferative diabetic retinopathy. Arch Ophthalmol 1987;105:1424-9.
13. Johnson PT, Lewis GP, Talaga KC, et al. Drusen-associated degeneration in the retina. Invest Ophthalmol Vis Sci 2003;44:4481-8.
14. Wu KH, Madigan MC, Billson FA, et al. Differential expression of GFAP in early v late AMD: a quantitative analysis. Br J Ophthalmol 2003;87:1159-66.
15. Guidry C, Medeiros NE, Curcio CA. Phenotypic variation of retinal pigment epithelium in age-related macular degeneration. Invest Ophthalmol Vis Sci 2002;43:267-73.
16. Roque RS, Caldwell RB. Pigment epithelial cell changes precede vascular transformations in the dystrophic rat retina. Exp Eye Res 1991;53:787-98.
17. Chinnery HR, McLenachan S, Humphries T, et al. Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX3CR1. Neurobiol Aging 2012;33:1769-76.