Identification of novel splicing variants from RON proto-oncogene pre-mRNA

Oncology Reports

Volumn 28, Issue 6, 2012, Pages 2217-2220

  Moon, Heegyum ^a   Cho, Sunghee ^a   Yang, Xiaoming ^b   Zhou, Jianhua ^b   Loh, Tiing Jen ^a   Zheng, Xuexiu ^a   Shen, Haihong ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b NANTONG UNIVERSITY   (China)

Author keywords

Exon; Intron; RON; Splicing; Variants

Indexed keywords

MESSENGER RNA PRECURSOR; RNA;

ALTERNATIVE RNA SPLICING; CANCER CELL; COLON CANCER; CONFERENCE PAPER; EXON; EXON SKIPPING; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INTRON; ONCOGENE RON; ONCOGENE RON DELTA 160; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTO ONCOGENE; RNA SPLICING; SEQUENCE ANALYSIS;

ALTERNATIVE SPLICING; BASE SEQUENCE; CELL LINE, TUMOR; HELA CELLS; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; RECEPTOR PROTEIN-TYROSINE KINASES; RNA PRECURSORS;

EID: 84868142964     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2043     Document Type: Conference Paper

References (27)

1. Ronsin C, Muscatelli F, Mattei MG and Breathnach R: A novel putative receptor protein tyrosine kinase of the met family. Oncogene 8:1195-1202, 1993. (Pubitemid 23129841)
2. Trusolino L and Comoglio PM: Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nature reviews. Cancer 2:289-300, 2002. (Pubitemid 37328782)
3. Wang MH, Wang D and Chen YQ: Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase. Carcinogenesis 24:1291-1300, 2003. (Pubitemid 37038819)
4. Van Der Geer P, Hunter T and Lindberg RA: Receptor proteintyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 10:251-337, 1994. (Pubitemid 24372822)
5. Robertson SC, Tynan J and Donoghue DJ: RTK mutations and human syndromes: when good receptors turn bad. Trends Genet 16:265-271, 2000. (Pubitemid 30332143)
6. Birchmeier W, Brinkmann V, Niemann C, et al: Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells. Ciba Found Symp 212:230-240, 1997.
7. Niranjan B, Buluwela L, Yant J, et al: HGF/SF: a potent cytokine for mammary growth, morphogenesis and development. Development 121:2897-2908, 1995.
8. Van De Woude GF, Jeffers M, Cortner J, Alvord G, Tsarfaty I and Resau J: Met-HGF/SF: tumorigenesis, invasion and metastasis. Ciba Found Symp 212:119-154, 1997.
9. Comoglio PM, Tamagnone L and Boccaccio C: Plasminogenrelated growth factor and semaphorin receptors: a gene superfamily controlling invasive growth. Exp Cell Res 253:88-99, 1999.
10. Xu XM, Zhou YQ and Wang MH: Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase. J Biol Chem 280:25087-25094, 2005.
11. Chen YQ, Zhou YQ, Angeloni D, Kurtz AL, Qiang XZ and Wang MH: Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines. Exp Cell Res 261:229-238, 2000.
12. Lu Y, Yao HP and Wang MH: Multiple variants of the RON receptor tyrosine kinase: biochemical properties, tumorigenic activities, and potential drug targets. Cancer Lett 257:157-164, 2007. (Pubitemid 47538834)
13. Gaudino G, Follenzi A, Naldini L, et al: RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J 13:3524-3532, 1994. (Pubitemid 24246189)
14. Skeel A, Yoshimura T, Showalter SD, Tanaka S, Appella E and Leonard EJ: Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. J Exp Med 173:1227-1234, 1991.
15. Bezerra JA, Witte DP, Aronow BJ and Degen SJ: Hepatocytespecific expression of the mouse hepatocyte growth factor-like protein. Hepatology 18:394-399, 1993. (Pubitemid 23225112)
16. Danilkovitch A and Leonard EJ: Kinases involved in MSP/RON signaling. J Leukoc Biol 65:345-348, 1999. (Pubitemid 29109707)
17. Danilkovitch-Miagkova A and Zbar B: Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. J Clin Invest 109:863-867, 2002. (Pubitemid 34275106)
18. Wang MH, Montero-Julian FA, Dauny I and Leonard EJ: Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein. Oncogene 13:2167-2175, 1996. (Pubitemid 26411567)
19. Santoro MM, Collesi C, Grisendi S, Gaudino G and Comoglio PM: Constitutive activation of the RON gene promotes invasive growth but not transformation. Mol Cell Biol 16:7072-7083, 1996. (Pubitemid 26389766)
20. Camp ER, Liu W, Fan F, Yang A, Somcio R and Ellis LM: RON, a tyrosine kinase receptor involved in tumor progression and metastasis. Ann Surg Oncol 12:273-281, 2005. (Pubitemid 40616491)
21. Rodrigues GA and Park M: Oncogenic activation of tyrosine kinases. Curr Opin Genet Dev 4:15-24, 1994. (Pubitemid 24060291)
22. Wang MH, Lee W, Luo YL, Weis MT and Yao HP: Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cells. J Pathol 213:402-411, 2007. (Pubitemid 350206512)
23. Wang MH, Kurtz AL and Chen Y: Identification of a novel splicing product of the RON receptor tyrosine kinase in human colorectal carcinoma cells. Carcinogenesis 21:1507-1512, 2000. (Pubitemid 30603978)
24. Wang MH, Lao WF, Wang D, Luo YL and Yao HP: Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain. Cancer Biol Ther 6:1121-1129, 2007. (Pubitemid 351574966)
25. Collesi C, Santoro MM, Gaudino G and Comoglio PM: A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol Cell Biol 16:5518-5526, 1996. (Pubitemid 26315071)
26. Zhou YQ, He C, Chen YQ, Wang D and Wang MH: Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential. Oncogene 22:186-197, 2003. (Pubitemid 36174176)
27. Eckerich C, Schulte A, Martens T, Zapf S, Westphal M and Lamszus K: RON receptor tyrosine kinase in human gliomas: expression, function, and identification of a novel soluble splice variant. J Neurochem 109:969-980, 2009.