A rare case of intracerebral hemorrhage complicating heparin-induced thrombocytopenia with thrombosis: A clinical dilemma ameliorated by novel use of plasmapheresis

International Journal of Hematology

Volumn 96, Issue 4, 2012, Pages 513-515

  Tun, Nay Min ^a   Bo, Zaw Min ^a   Ahluwalia, Meena ^a   Guevara, Elizabeth ^a   Villani, Gina M ^a  

^a BROOKLYN HOSPITAL CENTER   (United States)

Author keywords

Case report; Heparin induced thrombocytopenia; Intracerebral hemorrhage; Plasmapheresis; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; ARGATROBAN; CEFEPIME; HEPARIN; VANCOMYCIN;

AGED; ARTICLE; BRAIN HEMORRHAGE; CASE REPORT; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPUTER ASSISTED TOMOGRAPHY; DEEP VEIN THROMBOSIS; DISEASE COURSE; HEPARIN INDUCED THROMBOCYTOPENIA; HEPARIN INDUCED THROMBOCYTOPENIA WITH THROMBOSIS TYPE 2; HUMAN; MALE; MEDICAL HISTORY; OBESITY; PARTIAL THROMBOPLASTIN TIME; PLASMAPHERESIS; POLYCYTHEMIA; THROMBOCYTE COUNT; THROMBOSIS;

AGED; CEREBRAL HEMORRHAGE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; HEPARIN; HUMANS; MALE; PLASMAPHERESIS; PLATELET COUNT; THROMBOCYTOPENIA; THROMBOSIS; VENOUS THROMBOSIS;

EID: 84868141726     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-012-1161-3     Document Type: Article

References (24)

1. Martel N, Lee J, Wells PS. Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis. Blood. 2005;106:2710-5. (Pubitemid 41510744)
2. Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med. 1995;332:1330-5.
3. Harbrecht U, Bastians B, Kredteck A, et al. Heparin-induced thrombocytopenia in neurologic disease treated with unfractionated heparin. Neurology. 2004;62:657-9. (Pubitemid 38252817)
4. Girolami B, Prandoni P, Stefani PM, et al. The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study. Blood. 2003;101:2955-9. (Pubitemid 36857979)
5. Morris TA, Castrejon S, Devendra G, Gamst AC. No difference in risk for thrombocytopenia during treatment of pulmonary embolism and deep venous thrombosis with either low-molecular- weight heparin or unfractionated heparin: a metaanalysis. Chest. 2007;132:1131-9. (Pubitemid 47620984)
6. Warkentin TE, Sheppard JA, Sigouin CS, et al. Gender imbalance and risk factor interactions in heparin-induced thrombocytopenia. Blood. 2006;108:2937-41.
7. Rosenberger LH, Smith PW, Sawyer RG, et al. Bilateral adrenal hemorrhage: the unrecognized cause of hemodynamic collapse associated with heparin-induced thrombocytopenia. Crit Care Med. 2011;39:833-8.
8. Hertle DN, Hahnel S, Richter GM, et al. The use of danaparoid to manage coagulopathy in a neurosurgical patient with heparininduced thrombocytopenia type II and intracerebral haemorrhage. Br J Neurosurg. 2011;25:117-9.
9. Warkentin TE. Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol. 2003;121:535-55. (Pubitemid 36645375)
10. Kurtz LE, Yang S. Bilateral adrenal hemorrhage associated with heparin induced thrombocytopenia. Am J Hematol. 2007;82: 493-4. (Pubitemid 46849326)
11. Namias N. Chance favors the prepared mind: the association between heparin-induced thrombocytopenia and bilateral adrenal hemorrhage. Crit Care Med. 2011;39:912-3.
12. Tsai HC, Yen HC, Hsu JC, Lin CL. Heparin-induced thrombocytopenia associated with intra-tumour haemorrhage in cavernous sinus after cardiac myxoma surgery. Br J Neurosurg. 2009;23: 95-6.
13. Wester JP, Haas FJ, Biesma DH, et al. Thrombosis and hemorrhage in heparin-induced thrombocytopenia in seriously ill patients. Intensive Care Med. 2004;30:1927-34. (Pubitemid 39468415)
14. Pohl C, Harbrecht U, Greinacher A, et al. Neurologic complications in immune-mediated heparin-induced thrombocytopenia. Neurology. 2000;54:1240-5. (Pubitemid 30174041)
15. Hopkins CK, Goldfinger D. Platelet transfusions in heparininduced thrombocytopenia: a report of four cases and review of the literature. Transfusion. 2008;48:2128-32.
16. Hong AP, Cook DJ, Sigouin CS, Warkentin TE. Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia. Blood. 2003;101: 3049-51. (Pubitemid 36857994)
17. Bouvier JL, Lefevre P, Villain P, et al. Treatment of serious heparin-induced thrombocytopenia by plasma exchange: report on 4 cases. Thromb Res. 1988;51:335-6.
18. Kajitani M, Aguinaga M, Johnson CE, et al. Use of plasma exchange and heparin during cardiopulmonary bypass for a patient with heparin induced thrombocytopenia: a case report. J Card Surg. 2001;16:313-8. (Pubitemid 34121027)
19. Voeller RK, Melby SJ, Grizzell BE, Moazami N. Novel use of plasmapheresis in a patient with heparin-induced thrombocytopenia requiring urgent insertion of a left ventricular assist device under cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2010; 140:e56-8.
20. Welsby IJ, Um J, Milano CA, et al. Plasmapheresis and heparin reexposure as a management strategy for cardiac surgical patients with heparin-induced thrombocytopenia. Anesth Analg. 2010; 110:30-5.
21. Kramer R, Oberg-Higgins P, Russo L, Braxton JH. Heparininduced thrombocytopenia with thrombosis syndrome managed with plasmapheresis. Interact Cardiovasc Thorac Surg. 2009;8: 439-41.
22. Poullin P, Pietri PA, Lefevre P. Heparin-induced thrombocytopenia with thrombosis: successful treatment with plasma exchange. Br J Haematol. 1998;102:630-1. (Pubitemid 28346613)
23. Antonijevic NM, Savic NB, Perunicic J, et al. Salvage late plasmapheresis in a patient with pulmonary embolism caused by heparin-induced thrombocytopenia primarily resistant to danaparoid sodium and lepirudin. J Clin Apher. 2006;21:252-5. (Pubitemid 46043151)
24. Robinson JA, Lewis BE. Plasmapheresis in the management of heparin-induced thrombocytopenia. Semin Hematol. 1999;36: 29-32. (Pubitemid 29045508)