Epiprofin/Sp6 regulates Wnt-BMP signaling and the establishment of cellular junctions during the bell stage of tooth development

Cell and Tissue Research

Volumn 350, Issue 1, 2012, Pages 95-107

  Ibarretxe, Gaskon ^a   Aurrekoetxea, Maitane ^a   Crende, Olatz ^a   Badiola, Iker ^a   Jimenez Rojo, Lucia ^b   Nakamura, Takashi ^c   Yamada, Yoshihiko ^d   Unda, Fernando ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c TOHOKU UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Cell junction; Epiprofin Sp6; MDPC 23; Mouse Epfn(+ ); Epfn( ); Tooth development; Wnt catenin

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN 4; EPIPROFIN; GREEN FLUORESCENT PROTEIN; NESTIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMELOBLAST; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL JUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EPIPROFIN GENE; GAIN OF FUNCTION MUTATION; GENE; GENE FUNCTION; GENE LOCATION; GENE OVEREXPRESSION; INTRACELLULAR SIGNALING; LOSS OF FUNCTION MUTATION; MOLAR TOOTH; MOUSE; NONHUMAN; ODONTOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TOOTH DEVELOPMENT; TOOTH PAPILLA; UPREGULATION; WNT SIGNALING PATHWAY;

ADHERENS JUNCTIONS; AMELOBLASTS; ANIMALS; BETA CATENIN; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEINS; CELL PROLIFERATION; DENTAL ENAMEL; DENTAL PAPILLA; DENTAL PULP; GLYCOGEN SYNTHASE KINASE 3; INCISOR; INTERCELLULAR JUNCTIONS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MEMBRANE PROTEINS; MICE; MOLAR; MORPHOGENESIS; ODONTOBLASTS; OXIMES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS; TOOTH; WNT PROTEINS;

MUS;

EID: 84868138624     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-012-1459-8     Document Type: Article

References (28)

1. About I, Laurent-Maquin D, Lendahl U, Mitsiadis T (2000) Nestin expression in embryonic and adult human teeth under normal and pathological conditions. Am J Pathol 157:287-295
2. Amen M, Liu X, Vadlamudi U, Elizondo G, Diamond E, Engelhardt JF, Amendt BA (2007) Pitx-2 and β-catenin regulate Lef-1 isoform expression. Mol Cel Biol 27:7560-7573
3. Aurrekoetxea M, López J, García P, Ibarretxe G, Unda F (2012) Enhanced Wnt/β-catenin signaling during tooth morphogenesis impedes cell differentiation, and leads to alterations in the structure and mineralization of the adult tooth. Biol Cell. doi: 10.1111/boc.201100075
4. Balda M, Matter K (2009) Tight junctions and the regulation of gene expression. Biochim Biophys Acta 1788:761-767
5. Chen J, Lan Y, Baek JA, Gao Y, Jiang R (2009) Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol 334:174-185
6. Dassule H, Lewis P, Bei M, Maas R, McMahon A (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127:4775-4785
7. Fujimori S, Novak H, Weissenböck M, Jussila M, Gonçalves A, Zeller R, Galloway J, Thesleff I, Hartmann C (2010) Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol 348:97-106
8. Gritli-Linde A, Bei M, Maas R, Zhang X, Linde A, McMahon A (2002) Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129:5323-5337
9. Hanks CT, Fang D, Sun Z, Edwards CA, Butler WT (1998) Dentin-specific proteins in MDPC-23 cell line. Eur J Oral Sci 1998 (Suppl 1):260-266
10. Harris TJ, Tepass U (2010) Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol 11:502-514
11. Hertveldt V, Louryan S, Reeth T van, Drèze P, Vooren P van, Szpirer J, Szpirer C (2008) The development of several organs and appendages is impaired in mice lacking Sp6. Dev Dyn 237:883-892
12. Hill TP, Taketo MM, Birchmeier W, Hartmann C (2006) Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development 133:1219-1229
13. Järvinen E, Salazar-Ciudad I, Birchmeier W, Taketo M, Jernvall J, Thesleff I (2006) Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci USA 103:18627-18632
14. Jimenez-Rojo L, Ibarretxe G, Aurrekoetxea M, Vega S de, Nakamura T, Yamada Y, Unda F (2010a) Epiprofin/Sp6: a new player in the regulation of tooth development. Histol Histopathol 25:1621-1630
15. Jimenez-Rojo L, Aurrekoetxea M, Ibarretxe G, García P, Vega S de, Unda F (2010b) Reduced expression of tight junction proteins ZO-1 and claudin-1 in ameloblasts and odontoblasts of Epiprofin/Sp6 deficient mice. Bull GIRSO 49:102-103
16. Kim TH, Lee J, Baek J, Lee JC, Yang X, Taketo M, Jiang R, Cho ES (2011) Constitutive stabilization of β-catenin in the dental mesenchyme leads to excessive dentin and cementum formation. Biochem Biophys Res Commun 412:549-555
17. Liu F, Millar SE (2010) Wnt/β-catenin signaling in oral tissue development and disease. J Dent Res 89:318-330
18. Munne PM, Felszeghy S, Jussila M, Suomalainen M, Thesleff I, Jernvall J (2010) Splitting placodes: effects of bone morphogenetic protein and Activin on the patterning and identity of mouse incisors. Evol Dev 12:383-392
19. Nakamura T, Unda F, Vega S de, Vilaxa A, Fukumoto S, Yamada K, Yamada Y (2004) The Krüppel-like factor epiprofin is expressed by epithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferation. J Biol Chem 279:626-634
20. Nakamura T, Vega S de, Fukumoto S, Jimenez L, Unda F, Yamada Y (2008) Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number. J Biol Chem 283:4825-4833
21. Ruspita I, Miyoshi K, Muto T, Abe K, Horiguchi T, Noma T (2008) Sp6 downregulation of follistatin gene expression in ameloblasts. J Med Invest 55:87-98
22. Shu W, Guttentag S, Wang Z, Andl T, Ballard P, Lu MM, Piccolo S, Birchmeier W, Whitsett JA, Millar SE, Morrisey EE (2005) Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol 283:226-239
23. Talamillo A, Delgado I, Nakamura T, de-Vega S, Yoshitomi Y, Unda F, Birchmeier W, Yamada Y, Ros M (2010) Role of epiprofin, a zinc-finger transcription factor, in limb development. Dev Biol 337:363-374
24. Thesleff I, Tummers M (2009) Tooth organogenesis and regeneration (January 31, 2009). In: StemBook (ed) The Stem Cell Research Community, StemBook, doi: 10.3824/stembook.1.37.1, http://www.stembook.org
25. Tian X, Liu Z, Niu B, Zhang J, Tan TK, Lee SR, Zhao Y, Harris DC, Zheng G (2011) E-cadherin/β-catenin complex and the epithelial barrier. J Biomed Biotechnol 2011:567305
26. Utami TW, Miyoshi K, Hagita H, Yanuaryska RD, Horiguchi T, Noma T (2011) Possible linkage of SP6 transcriptional activity with amelogenesis by protein stabilization. J Biomed Biotechnol 2011:320987
27. Wang X, Suomalainen M, Jorgez C, Matzuk M, Werner S, Thesleff I (2004) Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell 7:719-730
28. Wang X, O'Connell D, Lund J, Saadi I, Kuraguchi M, Turbe-Doan A, Cavallesco R, Kim H, Park P, Harada H, Kucherlapati R, Maas R (2009) Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development 136:1939-1949