Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells

CNS Neuroscience and Therapeutics

Volumn 18, Issue 11, 2012, Pages 950-951

  Huang, Wen Yong ^a   Chao, Xiao Juan ^b   Ouyang, Ying ^b   Liu, An Min ^b   He, Xi Xin ^c   Chen, Mei Hui ^b   Wang, Lan Hua ^a   Liu, Jun ^b   Yu, Si Wang ^d   Rapposelli, Simona ^e   Pi, Rong Biao ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^d PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^e UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT; DIMER; HEME OXYGENASE 1; IONOTROPIC RECEPTOR; TACRINE 6 FERULIC ACID; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIOXIDANT RESPONSIVE ELEMENT; BINDING KINETICS; BIOACCUMULATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; DISEASE ASSOCIATION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; LETTER; MOLECULAR DYNAMICS; NERVE CELL NECROSIS; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ALZHEIMER DISEASE; ANIMALS; CELL DEATH; CELL LINE, TRANSFORMED; COUMARIC ACIDS; HEME OXYGENASE-1; MICE; NEURONS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEIN MULTIMERIZATION; REGULATORY ELEMENTS, TRANSCRIPTIONAL; SIGNAL TRANSDUCTION; TACRINE;

EID: 84868128029     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12010     Document Type: Letter

References (6)

1. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E. Alzheimer's disease. Lancet 2011;377:1019-1031.
2. Sultana R, Butterfield DA. Role of oxidative stress in the progression of Alzheimer's disease. J Alzheimers Dis 2010;19:341-353.
3. Calkins MJ, Johnson DA, Townsend JA, et al. The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid Redox Signal 2009;11:497-508.
4. Pi R, Mao X, Chao X, Cheng Z, et al. Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. PLoS ONE 2012;7:e31921.
5. Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT. Glutamate toxicity in neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 1989;2:1547-1558.
6. Joshi G, Johnson JA. The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases. Recent Pat CNS Drug Discov 2012, [Epub ahead of print].