-
1
-
-
20344392202
-
Epigenetics - An epicenter of gene regulation: Histones and histone-modifying enzymes
-
DOI 10.1002/anie.200461346
-
Biel, M., Wascholowski, V., and Giannis, A., Epigenetics-an epicenter of gene regulation: histones and histone-modifying enzymes. Angew. Chem. Int. Ed. Engl., 44, 3186-3216 (2005). (Pubitemid 40778337)
-
(2005)
Angewandte Chemie - International Edition
, vol.44
, Issue.21
, pp. 3186-3216
-
-
Biel, M.1
Wascholowski, V.2
Giannis, A.3
-
2
-
-
0037805679
-
Small molecule modulators of histone acetyltransferase p300
-
DOI 10.1074/jbc.M301580200
-
Balasubramanyam, K., Swaminathan, V., Ranganathan, A., and Kundu, T. K., Small molecule modulators of histone acetyltransferase p300. J. Biol. Chem., 278, 19134-19140 (2003). (Pubitemid 36799302)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.21
, pp. 19134-19140
-
-
Balasubramanyam, K.1
Swaminathan, V.2
Ranganathan, A.3
Kundu, T.K.4
-
3
-
-
10944243759
-
Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription
-
DOI 10.1074/jbc.M409024200
-
Balasubramanyam, K., Varier, R. A., Altaf, M., Swaminathan, V., Siddappa, N. B., Ranga, U., and Kundu, T. K., Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone protein and histone acetyltransferase-dependent chromatin. J. Biol. Chem., 279, 51163-51171 (2004). (Pubitemid 40017859)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.49
, pp. 51163-51171
-
-
Balasubramanyam, K.1
Varier, R.A.2
Altaf, M.3
Swaminathan, V.4
Siddappa, N.B.5
Ranga, U.6
Kundu, T.K.7
-
4
-
-
0038204415
-
The diverse functions of histone acetyltransferase complexes
-
DOI 10.1016/S0168-9525(03)00115-X
-
Carrozza, M. J., Utley, R. T., Workman, J. L., and Cote, J., The diverse functions of histone acetyl transferase complexes. Trends Genet., 19, 321-329 (2003). (Pubitemid 36694615)
-
(2003)
Trends in Genetics
, vol.19
, Issue.6
, pp. 321-329
-
-
Carrozza, M.J.1
Utley, R.T.2
Workman, J.L.3
Cote, J.4
-
5
-
-
7044235522
-
Synthesis of new N-(2-(trifluoromethyl)pyridin-4-yl)anthranilic acid derivatives and their evaluation as anticancer agents
-
DOI 10.1016/j.bmcl.2004.09.045, PII S0960894X04011679
-
Cocco, M. T, Congiu, C., Onnis, V., and Lilliu, V., Synthesis of new N-(2-trifluoromethyl)pyridine-4-yl)anthranilic acid derivatives and their evaluation as anticancer agents. Bioorg. Med. Chem. Lett., 14, 5787-5791 (2004). (Pubitemid 39421519)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.23
, pp. 5787-5791
-
-
Cocco, M.T.1
Congiu, C.2
Lilliu, V.3
Onnis, V.4
-
6
-
-
29744441083
-
New potential anticancer agents based on the anthranilic acid scaffold. Synthesis and evaluation of biological activity
-
DOI 10.1021/jm050711d
-
Congiu, C., Cocco, M. T., Lilliu, V., and Onnis, V., New potential anticancer agents based on the anthranilic acid scaffold. Synthesis and evaluation of biological activity. J. Med. Chem., 48, 8245-8252 (2005). (Pubitemid 43032533)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.26
, pp. 8245-8252
-
-
Congiu, C.1
Cocco, M.T.2
Lilliu, V.3
Onnis, V.4
-
7
-
-
54849423666
-
Synthesis of benzamide related to anacardic acid and their histone acetyltransferase (HAT) inhibiting activities
-
Conte, M., Alvarez, R., Nebbioso, A., Carafa, V., Altucci, L., and de Lera, A. R., Synthesis of benzamide related to anacardic acid and their histone acetyltransferase (HAT) inhibiting activities. ChemMedChem, 3, 1435-1442 (2008).
-
(2008)
ChemMedChem
, vol.3
, pp. 1435-1442
-
-
Conte, M.1
Alvarez, R.2
Nebbioso, A.3
Carafa, V.4
Altucci, L.5
De Lera, A.R.6
-
8
-
-
33947515716
-
Dietary components impact histone modifications and cancer risk
-
DOI 10.1111/j.1753-4887.2007.tb00285.x
-
Davis, C. D. and Ross, S. A., Dietary components impact histone modifications and cancer risk. Nutr. Rev., 65, 88-94 (2007). (Pubitemid 351804383)
-
(2007)
Nutrition Reviews
, vol.65
, Issue.2
, pp. 88-94
-
-
Davis, C.D.1
Ross, S.A.2
-
9
-
-
70349311616
-
Histone acetyl transferases as emerging drug targets
-
Dekker, F. J. and Haisma, H. J., Histone acetyl transferases as emerging drug targets. Drug Discov. Today, 14, 942-948 (2009a).
-
(2009)
Drug Discov. Today
, vol.14
, pp. 942-948
-
-
Dekker, F.J.1
Haisma, H.J.2
-
10
-
-
58549087523
-
Inhibition of the PCAF histone acetyl-transferase and cell proliferation by isothiazolones
-
Dekker, F. J., Ghizzoni, M., van der Meer, N., Wisastra, R., and Haisma, H. J., Inhibition of the PCAF histone acetyl-transferase and cell proliferation by isothiazolones. Bioorg. Med. Chem., 17, 460-466 (2009b).
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 460-466
-
-
Dekker, F.J.1
Ghizzoni, M.2
Van Der Meer, N.3
Wisastra, R.4
Haisma, H.J.5
-
11
-
-
0020699979
-
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
-
DOI 10.1038/301089a0
-
Feinberg, A. P. and Vogelstein, B., Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature, 301, 89-92 (1983). (Pubitemid 13154475)
-
(1983)
Nature
, vol.301
, Issue.5895
, pp. 89-92
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
12
-
-
77955473296
-
Improved inhibition of the histone acetyl transferase PCAF by an anacardic acid derivative
-
Ghizzoni, M., Boltjes, A., de Graaf, C, Haisma, H. J., and Dekker, F. J., Improved inhibition of the histone acetyl transferase PCAF by an anacardic acid derivative. Bioorg. Med. Chem., 18, 5826-5834 (2010).
-
(2010)
Bioorg. Med. Chem.
, vol.18
, pp. 5826-5834
-
-
Ghizzoni, M.1
Boltjes, A.2
De Graaf, C.3
Haisma, H.J.4
Dekker, F.J.5
-
13
-
-
34447627700
-
Molecular design of anti-MRSA agents based on the anacardic acid scaffold
-
Green, I. R., Tocoli, F. E., Lee, S. H., Nihei, K., and Kubo, L., Molecular design of anti-MRSA agents based on the anacardic acid scaffold. Bioorg. Med. Chem., 15, 6236 (2007).
-
(2007)
Bioorg. Med. Chem.
, vol.15
, pp. 6236
-
-
Green, I.R.1
Tocoli, F.E.2
Lee, S.H.3
Nihei, K.4
Kubo, L.5
-
14
-
-
1642358490
-
Linking the epigenetic 'language' of covalent histone modifications to cancer
-
DOI 10.1038/sj.bjc.6601575
-
Hake, S. B., Xiao, A., and Allis, C. D., Linking the epigenetic 'language' of covalent histone modification to cancer. Br. J. Cancer, 90, 761-769 (2004). (Pubitemid 38406583)
-
(2004)
British Journal of Cancer
, vol.90
, Issue.4
, pp. 761-769
-
-
Hake, S.B.1
Xiao, A.2
Allis, C.D.3
-
15
-
-
0028308714
-
Synthetic and β-lactamase inhibition of anacardic acids and their analogues
-
Hird, N. W. and Milner, P. H., Synthetic and β-lactamase inhibition of anacardic acids and their analogues. Bioorg. Med. Chem. Lett., 4, 1423-1426 (1994).
-
(1994)
Bioorg. Med. Chem. Lett.
, vol.4
, pp. 1423-1426
-
-
Hird, N.W.1
Milner, P.H.2
-
16
-
-
33644872992
-
Keynote review: Chromatin control and cancer-drug discovery: Realizing the promise
-
DOI 10.1016/S1359-6446(05)03691-3, PII S1359644605036913
-
Inche, A. G. and La Thangue, N. B., Chromatin control and cancer-drug discovery: realizing the promise. Drug Discov. Today, 11, 97-109 (2006). (Pubitemid 43375960)
-
(2006)
Drug Discovery Today
, vol.11
, Issue.3-4
, pp. 97-109
-
-
Inche, A.G.1
La Thangue, N.B.2
-
17
-
-
0033714888
-
HATs off: Selective synthetic inhibitors of the histone acetyltransferase p300 and PCAF
-
Lau, O. D., Kundu, T. K., and Soccio, R. E., HATs off: selective synthetic inhibitors of the histone acetyltransferase p300 and PCAF. Mol. Cell, 5, 589-595 (2000).
-
(2000)
Mol. Cell
, vol.5
, pp. 589-595
-
-
Lau, O.D.1
Kundu, T.K.2
Soccio, R.E.3
-
18
-
-
33750989910
-
Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties
-
DOI 10.1021/jm060601m
-
Mai, A., Rotili, D., Tarantino, D., Ornaghi, P., Tosi, F., Vicidomini, C., Sbaedella, G., Nebbioso, A., Miceli, M., Altucci, L., and Filetici, P., Small-molecular inhibitors of histone acetyltransferase activity: Identification and biological properties. J. Med. Chem., 49, 6897-6907 (2006). (Pubitemid 44749755)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.23
, pp. 6897-6907
-
-
Mai, A.1
Rotili, D.2
Tarantino, D.3
Ornaghi, P.4
Tosi, F.5
Vicidomini, C.6
Sbardella, G.7
Nebbioso, A.8
Miceli, M.9
Altucci, L.10
Filetici, P.11
-
19
-
-
0029940574
-
P300 gene alterations in colorectal and gastric carcinomas
-
Muraoka, M., Konishi, M., Kikuchi-Yanoshita, R., Tanaka, K., Shitara, N., Chong, J. M., Iwama, T., and Miyaki, M., p300 gene alteration in cololectal and gastric carcinoma. Oncogene, 12, 1565-1569 (1996). (Pubitemid 26132043)
-
(1996)
Oncogene
, vol.12
, Issue.7
, pp. 1565-1569
-
-
Muraoka, M.1
Konishi, M.2
Kikuchi-Yanoshita, R.3
Tanaka, K.4
Shitara, N.5
Chong, J.-M.6
Iwama, T.7
Miyaki, M.8
-
20
-
-
0035980617
-
Epigenetics: Interaction of DNA methylation and chromatin
-
DOI 10.1016/S0378-1119(01)00721-1, PII S0378111901007211
-
Nakao, M., Epigenetics: interaction of DNA methylation and chromatin. Gene, 278, 25-31 (2001). (Pubitemid 33055776)
-
(2001)
Gene
, vol.278
, Issue.1-2
, pp. 25-31
-
-
Nakao, M.1
-
21
-
-
0029152586
-
Nucleosomeal anatomy-where are the histones?
-
Pruss, D., Hayes, J. J., and Wolffe, A. P., Nucleosomeal anatomy-where are the histones? Bioessays, 17, 161-170 (1995).
-
(1995)
Bioessays
, vol.17
, pp. 161-170
-
-
Pruss, D.1
Hayes, J.J.2
Wolffe, A.P.3
-
22
-
-
42949089945
-
Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases
-
DOI 10.1016/j.bmcl.2008.04.017, PII S0960894X08004010
-
Sbardella, G., Castellano, S., Vicidomini, C., Rotili, D., Nebbioso, A., Miceli, M., Aitucci, L., and Mai, A., Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyl transferases. Bioorg. Med. Chem. Lett., 18, 2788-2792 (2008). (Pubitemid 351608893)
-
(2008)
Bioorganic and Medicinal Chemistry Letters
, vol.18
, Issue.9
, pp. 2788-2792
-
-
Sbardella, G.1
Castellano, S.2
Vicidomini, C.3
Rotili, D.4
Nebbioso, A.5
Miceli, M.6
Altucci, L.7
Mai, A.8
-
23
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bodesh, H., Kenny, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst., 82, 1107-1112 (1990). (Pubitemid 20213250)
-
(1990)
Journal of the National Cancer Institute
, vol.82
, Issue.13
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
Monks, A.4
McMahon, J.5
Vistica, D.6
Warren, J.T.7
Bokesch, H.8
Kenney, S.9
Boyd, M.R.10
-
24
-
-
54849423666
-
Synthesis of benzamides related to anacardic acid and their histone acetyl-transferase (HAT) inhibitory activities
-
Souto, J. A., Conte, M., Alvarez, R., Nebbioso, A., Carafa, V., Aitucci, L., and de Lera, A. R., Synthesis of benzamides related to anacardic acid and their histone acetyl-transferase (HAT) inhibitory activities. ChemMedChem, 3, 1435-1442 (2008).
-
(2008)
ChemMedChem
, vol.3
, pp. 1435-1442
-
-
Souto, J.A.1
Conte, M.2
Alvarez, R.3
Nebbioso, A.4
Carafa, V.5
Aitucci, L.6
De Lera, A.R.7
-
25
-
-
27644473204
-
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity
-
DOI 10.1158/1535-7163.MCT-05-0135
-
Stimson, L., Rowlands, M. G., Newbatt, Y. M., Smith, N. F., Raynaud, F. I., Rogers, P., Bavetsias, V., Gorsuch, S., Jarman, M., Bannister, A., Kouzarides, T., McDonald, E., Workman, P., and Aherne, G. W., Isothiazolones as inhibitors of PCAF and p300 histone acetyl-transferase activity. Mol. Cancer Ther., 4, 1521-1532 (2005). (Pubitemid 41556434)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.10
, pp. 1521-1532
-
-
Stimson, L.1
Rowlands, M.G.2
Newbatt, Y.M.3
Smith, N.F.4
Raynaud, F.I.5
Rogers, P.6
Bavetsias, V.7
Gorsuch, S.8
Jarman, M.9
Bannister, A.10
Kouzarides, T.11
McDonald, E.12
Workman, P.13
Aherne, G.W.14
-
26
-
-
0034672126
-
Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor
-
DOI 10.1006/abio.2000.4855
-
Trievel, R. C., Li, F. Y., and Marmorstein, R., Appliaction of a fluorescent histone acetyltransferase assay to probe the substrate specificity of human p300/CBP-associated factor. Anal. Biochem., 287, 319-328 (2000). (Pubitemid 32006243)
-
(2000)
Analytical Biochemistry
, vol.287
, Issue.2
, pp. 319-328
-
-
Trievel, R.C.1
Li, F.-Y.2
Marmorstein, R.3
-
27
-
-
0001236221
-
Syntheses of anacardic acids and ginkgoic acid
-
Yamagiwa, Y., Ohashi, K., Sakamota, Y., Hirakawa, S., Kamikawa, T., and Kubo, I., Syntheses of anacardic acids and ginkgoic acid. Tetrahedron, 43, 3387-3394 (1987).
-
(1987)
Tetrahedron
, vol.43
, pp. 3387-3394
-
-
Yamagiwa, Y.1
Ohashi, K.2
Sakamota, Y.3
Hirakawa, S.4
Kamikawa, T.5
Kubo, I.6
-
28
-
-
0344010953
-
Tranilast (N-3,4-Dimethoxycinamoyl Anthranilic Acid): A Novel Inhibitor of Invasion-stimulating Interaction between Gastric Cancer Cells and Orthotopic Fibroblasts
-
Yashiro, M., Murahashi, K., Matsuoka, T., Tanaka, H., Osaka, H., Koyama, T., Ohira, M., and Chung, K. H., Tranilast (N-3,4-dimethoxycinnamyl anthranilic acid: A novel inhibitor of invasion-stimulating interaction between gastric cancer cells as orthotopic fibroblasts. Anticancer Res., 23, 3899-3904 (2003). (Pubitemid 37474340)
-
(2003)
Anticancer Research
, vol.23
, Issue.5 A
, pp. 3899-3904
-
-
Yashiro, M.1
Murahashi, K.2
Matsuoka, T.3
Nakazawa, K.4
Tanaka, H.5
Osaka, H.6
Koyama, T.7
Ohira, M.8
Chung, K.H.-Y.S.9
-
29
-
-
0033569641
-
Epigenetics: Regulation through repression
-
Wolffe, A. P. and Matzke, M. A., Epigenetics: regulation through repression. Science, 286, 481-486 (1999).
-
(1999)
Science
, vol.286
, pp. 481-486
-
-
Wolffe, A.P.1
Matzke, M.A.2
|