XenomiRs and miRNA homeostasis in health and disease: Evidence that diet and dietary miRNAs directly and indirectly influence circulating miRNA profiles

RNA Biology

Volumn 9, Issue 9, 2012, Pages 1147-1154

  Witwer, Kenneth W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biomarker; Cancer; Cholesterol; Diet; HDL; Homeostasis; LDL; microRNA; Nutrition; XenomiR

Indexed keywords

EID: 84868093811     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.4161/rna.21619     Document Type: Review

References (102)

1. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215-33; PMID:19167326; http://dx.doi.org/10.1016/j.cell.2009.01.002.
2. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19:92-105; PMID:18955434; http://dx.doi.org/10.1101/gr.082701.108.
3. Mendell JT, Olson EN. MicroRNAs in stress signaling and human disease. Cell 2012; 148:1172-87; PMID:22424228; http://dx.doi.org/10.1016/j.cell.2012.02. 005.
4. Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH, Lee MJ, et al. The microRNA spectrum in 12 body fluids. Clin Chem 2010; 56:1733-41; PMID:20847327; http://dx.doi.org/10.1373/clinchem.2010.147405.
5. Kosaka N, Iguchi H, Ochiya T. Circulating microR-NA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci 2010; 101:2087-92; PMID:20624164; http://dx.doi.org/10.1111/j.1349-7006.2010.01650.x.
6. Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 2011; 13:423-33; PMID:21423178; http://dx.doi.org/ 10.1038/ncb2210.
7. Turchinovich A, Weiz L, Langheinz A, Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res 2011; 39:7223-33; PMID:21609964; http://dx.doi.org/10.1093/nar/gkr254.
8. Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 2011; 108:5003-8; PMID:21383194; http://dx.doi.org/10.1073/pnas.1019055108.
9. Winter J, Diederichs S. Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization. RNA Biol 2011; 8:1149-57; PMID:21941127; http://dx.doi.org/10. 4161/rna.8.6.17665.
10. Oosta G, Razvi E. Analysis of miRNA market trends reveals hotspots of research activity. Epigenomics 2012; 4:237-40; PMID:22449194; http://dx.doi.org/10.2217/epi.12.14.
11. Weiland M, Gao XH, Zhou L, Mi QS. Small RNAs have a large impact: Circulating microRNAs as bio-markers for human diseases. RNA Biol 2012; 9:850-9; PMID:22699556; http://dx.doi.org/10.4161/rna.20378.
12. Soci UP, Fernandes T, Hashimoto NY, Mota GF, Amadeu MA, Rosa KT, et al. MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats. Physiol Genomics 2011; 43:665-73; PMID:21447748; http://dx.doi.org/10.1152/physiol-genomics.00145.2010.
13. Liu G, Detloff MR, Miller KN, Santi L, Houlé JD. Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. Exp Neurol 2012; 233:447-56; PMID:22123082; http://dx.doi.org/10.1016/j. expneurol.2011.11.018.
14. Nielsen S, Scheele C, Yfanti C, Akerström T, Nielsen AR, Pedersen BK, et al. Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle. J Physiol 2010; 588:4029-37; PMID:20724368; http://dx.doi.org/10.1113/jphysiol.2010.189860.
15. Radom-Aizik S, Zaldivar F Jr., Leu SY, Adams GR, Oliver S, Cooper DM. Effects of exercise on microR-NA expression in young males peripheral blood mononuclear cells. Clin Transl Sci 2012; 5:32-8; PMID:22376254; http://dx.doi.org/10.1111/j.1752-8062.2011.00384.x.
16. Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, et al. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. J Physiol 2011; 589:3983-94; PMID:21690193; http://dx.doi.org/10.1113/jphysiol.2011.213363.
17. Somel M, Guo S, Fu N, Yan Z, Hu HY, Xu Y, et al. MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res 2010; 20:1207-18; PMID:20647238; http://dx.doi.org/10.1101/gr.106849.110.
18. Huang RS, Gamazon ER, Ziliak D, Wen Y, Im HK, Zhang W, et al. Population differences in microRNA expression and biological implications. RNA Biol 2011; 8:692-701; PMID:21691150; http://dx.doi.org/10.4161/rna.8.4.16029.
19. Schmidt WM, Spiel AO, Jilma B, Wolzt M, Müller M. In vivo profile of the human leukocyte microR-NA response to endotoxemia. Biochem Biophys Res Commun 2009; 380:437-41; PMID:19284987; http://dx.doi.org/10.1016/j.bbrc.2008. 12.190.
20. Witwer K W, Sarbanes SL, Liu J, Clements JE. A plasma microRNA signature of acute lentiviral infection: biomarkers of CNS disease. AIDS 2011; 204:1104-14.
21. Rong H, Liu TB, Yang KJ, Yang HC, Wu DH, Liao CP, et al. MicroRNA-134 plasma levels before and after treatment for bipolar mania. J Psychiatr Res 2011; 45:92-5; PMID:20546789; http://dx.doi.org/10.1016/j.jpsychires.2010.04. 028.
22. Rodrigues AC, Li X, Radecki L, Pan YZ, Winter JC, Huang M, et al. MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines. Biopharm Drug Dispos 2011; 32:355-67; PMID:21796641; http://dx.doi.org/10.1002/bdd.764.
23. Wang X, Ye L, Zhou Y, Liu MQ, Zhou DJ, Ho WZ. Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytes. Am J Pathol 2011; 178:41-7; PMID:21224041; http://dx.doi.org/10.1016/j.ajpath.2010.11.042.
24. Wang LL, Zhang Z, Li Q, Yang R, Pei X, Xu Y, et al. Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum Reprod 2009; 24:562-79; PMID:19091803; http://dx.doi.org/10.1093/humrep/den439.
25. Guo Y, Chen Y, Carreon S, Qiang M. Chronic Intermittent Ethanol Exposure and Its Removal Induce a Different miRNA Expression Pattern in Primary Cortical Neuronal Cultures. Alcohol Clin Exp Res 2011; 36:1058-66; PMID:22141737.
26. Soares AR, Pereira PM, Ferreira V, Reverendo M, Simões J, Bezerra AR, et al. Ethanol exposure induces upregulation of specific microRNAs in zebrafish embryos. Toxicol Sci 2012; 127:18-28; PMID:22298809; http://dx.doi.org/10.1093/toxsci/kfs068.
27. Duttagupta R, Jiang R, Gollub J, Getts RC, Jones KW. Impact of cellular miRNAs on circulating miRNA biomarker signatures. PLoS One 2011; 6:e20769; PMID:21698099; http://dx.doi.org/10.1371/journal.pone.0020769.
28. Ross SA, Davis CD. MicroRNA, nutrition, and cancer prevention. Adv Nutr 2011; 2:472-85; PMID:22332090; http://dx.doi.org/10.3945/an.111.001206.
29. Ryu MS, Langkamp-Henken B, Chang SM, Shankar MN, Cousins RJ. Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeosta-sis. Proc Natl Acad Sci USA 2011; 108:20970-5; PMID:22171008; http://dx.doi.org/10.1073/pnas.1117207108.
30. Davis CD, Ross SA. Evidence for dietary regulation of microRNA expression in cancer cells. Nutr Rev 2008; 66:477-82; PMID:18667010; http://dx.doi.org/10. 1111/j.1753-4887.2008.00080.x.
31. Buhtz A, Pieritz J, Springer F, Kehr J. Phloem small RNAs, nutrient stress responses, and systemic mobility. BMC Plant Biol 2010; 10:64; PMID:20388194; http://dx.doi.org/10.1186/1471-2229-10-64.
32. Dy SM, Lorenz KA, Naeim A, Sanati H, Walling A, Asch SM. Evidence-based recommendations for cancer fatigue, anorexia, depression, and dyspnea. J Clin Oncol 2008; 26:3886-95; PMID:18688057; http://dx.doi.org/10.1200/JCO.2007.15. 9525.
33. Teunissen SC, Wesker W, Kruitwagen C, de Haes HC, Voest EE, de Graeff A. Symptom prevalence in patients with incurable cancer: a systematic review. J Pain Symptom Manage 2007; 34:94-104; PMID:17509812; http://dx.doi.org/10.1016/j. jpain-symman.2006.10.015. (Pubitemid 46970881)
34. Esper DH, Harb WA. The cancer cachexia syndrome: a review of metabolic and clinical manifestations. Nutr Clin Pract 2005; 20:369-76; PMID:16207677; http://dx.doi.org/10.1177/0115426505020004369. (Pubitemid 47050807)
35. Martinez-Outschoorn UE, Whitaker-Menezes D, Pavlides S, Chiavarina B, Bonuccelli G, Casey T, et al. The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox. Cell Cycle 2010; 9:4297-306; PMID:21051947; http://dx.doi.org/10.4161/ cc.9.21.13817.
36. Blum D, Omlin A, Baracos VE, Solheim TS, Tan BH, Stone P, et al.; European Palliative Care Research Collaborative. Cancer cachexia: a systematic literature review of items and domains associated with involuntary weight loss in cancer. Crit Rev Oncol Hematol 2011; 80:114-44; PMID:21216616; http://dx.doi.org/10.1016/j.critrevonc.2010.10.004.
37. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011; 12:489-95; PMID:21296615; http://dx.doi.org/10. 1016/S1470-2045(10)70218-7.
38. Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res 2012; 22:107-26; PMID:21931358; http://dx.doi.org/10.1038/cr.2011.158.
39. Chen X, Gao C, Li H, Huang L, Sun Q, Dong Y, et al. Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res 2010; 20:1128-37; PMID:20548333; http://dx.doi.org/10.1038/cr.2010.80.
40. Konsman JP, Dantzer R. How the immune and nervous systems interact during disease-associated anorexia. Nutrition 2001; 17:664-8; PMID:11448593; http://dx.doi.org/10.1016/S0899-9007(01)00602-5. (Pubitemid 32633804)
41. Oguntibeju OO, van den Heever WM, Van Schalkwyk FE. The interrelationship between nutrition and the immune system in HIV infection: a review. Pak J Biol Sci 2007; 10:4327-38; PMID:19093495; http://dx.doi.org/10.3923/pjbs.2007.4327. 4338. (Pubitemid 350305597)
42. Faintuch J, Soeters PB, Osmo HG. Nutritional and metabolic abnormalities in pre-AIDS HIV infection. Nutrition 2006; 22:683-90; PMID:16704957; http://dx.doi.org/10.1016/j.nut.2006.03.011.
43. Argilés JM, López-Soriano FJ, Busquets S. Novel approaches to the treatment of cachexia. Drug Discov Today 2008; 13:73-8; PMID:18190867; http://dx.doi.org/10.1016/j.drudis.2007.10.008.
44. Ismail FW, Khan RA, Kamani L, Wadalawala AA, Shah HA, Hamid SS, et al. Nutritional status in patients with hepatitis C. J Coll Physicians Surg Pak 2012; 22:139-42; PMID:22414351.
45. Lee HC, Li L, Gu W, Xue Z, Crosthwaite SK, Pertsemlidis A, et al. Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi. Mol Cell 2010; 38:803-14; PMID:20417140; http://dx.doi.org/10. 1016/j.molcel.2010.04.005.
46. Akhtar S. Oral delivery of siRNA and anti-sense oligonucleotides. J Drug Target 2009; 17:491-5; PMID:19530907; http://dx.doi.org/10.1080/ 10611860903057674.
47. Aouadi M, Tesz GJ, Nicoloro SM, Wang M, Chouinard M, Soto E, et al. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 2009; 458:1180-4; PMID:19407801; http://dx.doi.org/10.1038/ nature07774.
48. Xu J, Ganesh S, Amiji M. Non-condensing polymeric nanoparticles for targeted gene and siRNA delivery. Int J Pharm 2012; 427:21-34; PMID:21621597; http://dx.doi.org/10.1016/j.ijpharm.2011.05.036.
49. Hata T, Murakami K, Nakatani H, Yamamoto Y, Matsuda T, Aoki N. Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs. Biochem Biophys Res Commun 2010; 396:528-33; PMID:20434431; http://dx.doi.org/10.1016/j. bbrc.2010.04.135.
50. Schorey JS, Bhatnagar S. Exosome function: from tumor immunology to pathogen biology. Traffic 2008; 9:871-81; PMID:18331451; http://dx.doi.org/10. 1111/j.1600-0854.2008.00734.x. (Pubitemid 351639493)
51. Soo CY, Song Y, Zheng Y, Campbell EC, Riches AC, Gunn-Moore F, et al. Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells. Immunology 2012; 136:192-7; PMID: 22348503; http://dx.doi.org/10. 1111/j.1365-2567.2012.03569.x.
52. Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, et al. MicroRNAs bind to Tolllike receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci USA 2012; 109:E2110-6; PMID:22753494; http://dx.doi.org/10.1073/pnas.1209414109.
53. Jiang M, Sang X, Hong Z. Beyond nutrients: food-derived microRNAs provide cross-kingdom regulation. Bioessays 2012; 34:280-4; PMID:22354805; http://dx.doi.org/10.1002/bies.201100181.
54. Hirschi KD. New foods for thought. Trends Plant Sci 2012; 17:123-5; PMID:22265093; http://dx.doi.org/10.1016/j.tplants.2012.01.004.
55. Kosaka N, Ochiya T. Unraveling the Mystery of Cancer by Secretory microRNA: Horizontal microR-NA Transfer between Living Cells. Front Genet 2011; 2:97; PMID:22303391.
56. Wei LQ, Yan LF, Wang T. Deep sequencing on genome-wide scale reveals the unique composition and expression patterns of microRNAs in developing pollen of Oryza sativa. Genome Biol 2011; 12:R53; PMID:21679406; http://dx.doi.org/10. 1186/gb-2011-12-6-r53.
57. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005; 33:e179; PMID:16314309; http://dx.doi.org/10.1093/nar/gni178.
58. Bissels U, Wild S, Tomiuk S, Holste A, Hafner M, Tuschl T, et al. Absolute quantification of microRNAs by using a universal reference. RNA 2009; 15:2375-84; PMID:19861428; http://dx.doi.org/10.1261/rna.1754109.
59. Kurashige J, Kamohara H, Watanabe M, Tanaka Y, Kinoshita K, Saito S, et al. Serum microRNA-21 is a novel biomarker in patients with esophageal squa-mous cell carcinoma. J Surg Oncol 2012; 106:188-92; PMID:22354855; http://dx.doi.org/10.1002/jso.23064.
60. Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Morimura R, Nagata H, et al. Circulating microR-NAs in plasma of patients with oesophageal squa-mous cell carcinoma. Br J Cancer 2011; 105:104-11; PMID:21673684; http://dx.doi.org/10. 1038/bjc.2011.198.
61. Zhang C, Wang C, Chen X, Yang C, Li K, Wang J, et al. Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem 2010; 56:1871-9; PMID:20943850; http://dx.doi.org/10.1373/clinchem. 2010.147553.
62. Zhang HS, Wu TC, Sang W W, Ruan Z. MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1. Biochim Biophys Acta 2012; 1823:1017-23; PMID:22406815; http://dx.doi.org/10. 1016/j.bbamcr.2012.02.014.
63. Wang K, Zhang S, Weber J, Baxter D, Galas DJ. Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res 2010; 38:7248-59; PMID:20615901; http://dx.doi.org/10.1093/nar/gkq601.
64. Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, et al. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 2010; 328:1566-9; PMID:20466882; http://dx.doi.org/10.1126/ sci-ence.1189123.
65. Rayner KJ, Suárez Y, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, et al. MiR-33 contributes to the regulation of cholesterol homeostasis. Science 2010; 328:1570-3; PMID:20466885; http://dx.doi.org/10.1126/ science.1189862.
66. Sun D, Zhang J, Xie J, Wei W, Chen M, Zhao X. MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7. FEBS Lett 2012; 586:1472-9; PMID:22673513; http://dx.doi.org/10.1016/j.febslet.2012.03.068.
67. Kim J, Yoon H, Ramírez CM, Lee SM, Hoe HS, Fernández- Hernando C, et al. MiR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression. Exp Neurol 2012; 235:476-83; PMID:22119192; http://dx.doi.org/10.1016/j.expneurol.2011.11.010.
68. Boutz DR, Collins PJ, Suresh U, Lu M, Ramírez CM, Fernández-Hernando C, et al. Two-tiered approach identifies a network of cancer and liver disease-related genes regulated by miR-122. J Biol Chem 2011; 286:18066-78; PMID:21402708; http://dx.doi.org/10.1074/jbc.M110.196451.
69. Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006; 3:87-98; PMID:16459310; http://dx.doi.org/10.1016/j.cmet.2006.01. 005.
70. Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, et al. The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. Biochem Biophys Res Commun 2009; 385:492-6; PMID:19460359; http://dx.doi.org/10.1016/j.bbrc.2009.05. 058.
71. Ou Z, Wada T, Gramignoli R, Li S, Strom SC, Huang M, et al. MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation. Mol Endocrinol 2011; 25:584-96; PMID:21310851; http://dx.doi.org/10.1210/me.2010-0360.
72. Ramirez CM, Dávalos A, Goedeke L, Salerno AG, Warrier N, Cirera-Salinas D, et al. MicroRNA-758 regulates cholesterol efflux through posttranscrip-tional repression of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol 2011; 31:2707-14; PMID:21885853; http://dx.doi.org/10.1161/ATVBAHA.111.232066.
73. Fernández-Hernando C, Moore KJ. MicroRNA modulation of cholesterol homeostasis. Arterioscler Thromb Vasc Biol 2011; 31:2378-82; PMID:22011750; http://dx.doi.org/10.1161/ATVBAHA.111.226688.
74. Dávalos A, Goedeke L, Smibert P, Ramírez CM, Warrier NP, Andreo U, et al. miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci USA 2011; 108:9232-7; PMID:21576456; http://dx.doi.org/10.1073/pnas.1102281108.
75. Shah AA, Leidinger P, Keller A, Wendschlag A, Backes C, Baus-Loncar M, et al. The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism. RNA Biol 2011; 8:77-81; PMID:21289491; http://dx.doi.org/10.4161/ rna.8.1.13687.
76. Tarling EJ, Edwards PA. Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis. Biochim Biophys Acta 2012; 1821:386-95; PMID:21824529; http://dx.doi.org/10.1016/j.bbalip.2011.07.011.
77. Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, et al. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest 2011; 121:2921-31; PMID:21646721; http://dx.doi.org/10.1172/JCI57275.
78. Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature 2011; 478:404-7; PMID:22012398; http://dx.doi.org/10. 1038/nature10486.
79. Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 2010; 285:17442-52; PMID:20353945; http://dx.doi.org/10.1074/jbc.M110. 107821.
80. Chen TS, Lai RC, Lee MM, Choo AB, Lee CN, Lim SK. Mesenchymal stem cell secretes micropar-ticles enriched in pre-microRNAs. Nucleic Acids Res 2010; 38:215-24; PMID:19850715; http://dx.doi.org/10.1093/nar/gkp857.
81. Vickers KC, Remaley AT. Lipid-based carriers of microRNAs and intercellular communication. Curr Opin Lipidol 2012; 23:91-7; PMID:22418571; http://dx.doi.org/10.1097/MOL.0b013e328350a425.
82. Yanai I, Benjamin H, Shmoish M, Chalifa-Caspi V, Shklar M, Ophir R, et al. Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics 2005; 21:650-9; PMID:15388519; http://dx.doi.org/10.1093/bioinformatics/bti042. (Pubitemid 40424791)
83. Shmueli O, Horn-Saban S, Chalifa-Caspi V, Shmoish M, Ophir R, Benjamin-Rodrig H, et al. GeneNote: whole genome expression profiles in normal human tissues. C R Biol 2003; 326:1067-72; PMID:14744114; http://dx.doi.org/10. 1016/j.crvi.2003.09.012. (Pubitemid 38016462)
84. Assanasen C, Mineo C, Seetharam D, Yuhanna IS, Marcel YL, Connelly MA, et al. Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling. J Clin Invest 2005; 115:969-77; PMID:15841181. (Pubitemid 40489401)
85. Kocher O, Birrane G, Tsukamoto K, Fenske S, Yesilaltay A, Pal R, et al. In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1. J Biol Chem 2010; 285:34999-5010; PMID:20739281; http://dx.doi.org/10.1074/jbc.M110.164418.
86. Rigotti A, Trigatti BL, Penman M, Rayburn H, Herz J, Krieger M. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci USA 1997; 94:12610-5; PMID:9356497; http://dx.doi.org/10.1073/pnas.94.23.12610. (Pubitemid 27492576)
87. Kocher O, Yesilaltay A, Cirovic C, Pal R, Rigotti A, Krieger M. Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. J Biol Chem 2003; 278:52820-5; PMID:14551195; http://dx.doi.org/10.1074/jbc.M310482200. (Pubitemid 38035880)
88. He XX, Chang Y, Meng FY, Wang MY, Xie QH, Tang F, et al. MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene 2011; 31:3357-69; PMID:22056881.
89. Zanella AM, Nakazone MA, Pinhel MA, Souza DR. Lipid profile, apolipoprotein A-I and oxidative stress in professional footballers, sedentary individuals, and their relatives. Arq Bras Endocrinol Metabol 2011; 55:121-6; PMID:21584429; http://dx.doi.org/10.1590/S0004-27302011000200004.
90. Stahl SM, Mignon L, Meyer JM. Which comes first: atypical antipsychotic treatment or cardiometa-bolic risk? Acta Psychiatr Scand 2009; 119:171-9; PMID:19178394; http://dx.doi.org/10.1111/j.1600-0447.2008.01334.x.
91. Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A, et al. Tanycytes of the hypo-thalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci 2012; 15:700-2; PMID:22446882; http://dx.doi.org/10.1038/ nn.3079.
92. Collino F, Deregibus MC, Bruno S, Sterpone L, Aghemo G, Viltono L, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One 2010; 5:e11803; PMID:20668554; http://dx.doi.org/10.1371/jour-nal.pone.0011803.
93. Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 2008; 3:e3694; PMID:19002258; http://dx.doi.org/10.1371/journal.pone.0003694.
94. Müller G, Schneider M, Biemer-Daub G, Wied S. Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis. Cell Signal 2011; 23:1207-23; PMID:21435393; http://dx.doi.org/10.1016/j.cellsig.2011.03.013.
95. Montecalvo A, Larregina AT, Shufesky WJ, Stolz DB, Sullivan ML, Karlsson JM, et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 2012; 119:756-66; PMID:22031862; http://dx.doi.org/ 10.1182/blood-2011-02-338004.
96. Petrocca F, Lieberman J. Micromanipulating cancer: microRNA-based therapeutics? RNA Biol 2009; 6:335-40; PMID:19535911; http://dx.doi.org/10.4161/ rna.6.3.9013.
97. Witwer KW, Clements JE. Evidence for miRNA expression differences of HIV-1-positive, treatment-naive patients and elite suppressors: a re-analysis. Blood 2012; 119:6395-6; PMID:22745299; http://dx.doi.org/10.1182/blood-2012-02- 412742.
98. Fare TL, Coffey EM, Dai H, He YD, Kessler DA, Kilian KA, et al. Effects of atmospheric ozone on microarray data quality. Anal Chem 2003; 75:4672-5; PMID:14632079; http://dx.doi.org/10.1021/ac034241b. (Pubitemid 37082262)
99. Lusa L, McShane LM, Reid JF, De Cecco L, Ambrogi F, Biganzoli E, et al. Challenges in projecting clustering results across gene expression-profiling datasets. J Natl Cancer Inst 2007; 99:1715-23; PMID:18000217; http://dx.doi.org/10.1093/jnci/djm216. (Pubitemid 351767219)
100. Pritchard CC, Kroh E, Wood B, Arroyo JD, Dougherty KJ, Miyaji MM, et al. Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. Cancer Prev Res (Phila) 2012; 5:492-7; PMID:22158052; http://dx.doi.org/10.1158/1940-6207.CAPR-11-0370.
101. Li LM, Hu ZB, Zhou ZX, Chen X, Liu FY, Zhang JF, et al. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res 2010; 70:9798-807; PMID:21098710; http://dx.doi.org/10.1158/0008-5472.CAN-10-1001.
102. Chen Y, Li L, Zhou Z, Wang N, Zhang CY, Zen K. A pilot study of serum microRNA signatures as a novel biomarker for occult hepatitis B virus infection. Med Microbiol Immunol 2012; 201:389-95; PMID:22392036.