Mice harboring GNRHR E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failure

Molecular Endocrinology

Volumn 26, Issue 11, 2012, Pages 1847-1856

  David Stewart, M ^a,c   Deng, Jian Ming ^a   Allison Stewart, C ^a   Mullen, Rachael D ^a   Wang, Ying ^a   Lopez, Suhujey ^c   Katalina Serna, M ^a,c   Huang, Cheng Chiu ^a,b   Janovick, Jo Ann ^d   Pask, Andrew J ^a,e   Schwartz, Robert J ^c   Michael Conn, P ^d   Behringer, Richard R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c University of Houston   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; FEMALE; FEMALE INFERTILITY; HYPOGONADOTROPIC HYPOGONADISM; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NONHUMAN; OVARY INSUFFICIENCY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN UNFOLDING; SIGNAL TRANSDUCTION; TESTIS ATROPHY; TESTIS SIZE; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; ANOVULATION; BASE SEQUENCE; ESTROUS CYCLE; FEMALE; GENE EXPRESSION REGULATION; GONADOTROPINS; HOMOZYGOTE; HUMANS; HYPOGONADISM; LUTEINIZATION; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTATION; ORGAN SIZE; PROTEOSTASIS DEFICIENCIES; RECEPTORS, LHRH; TESTIS;

ANIMALIA; MUS;

EID: 84868087582     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2012-1072     Document Type: Article

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