메뉴 건너뛰기




Volumn 9, Issue 4, 2012, Pages 702-709

New and Unconventional Treatments for Obstructive Sleep Apnea

Author keywords

APAP; bariatric surgery; continuous positive airway pressure; CPAP; electrical stimulation; nasal dilators; nasal valves; neuromuscular stimulation; obstructive sleep apnea; positional therapy; snoring; weight reduction

Indexed keywords

ARMODAFINIL; FLUOXETINE; MIRTAZAPINE; OXYGEN; PAROXETINE; PHENTERMINE PLUS TOPIRAMATE; PLACEBO; PROTRIPTYLINE;

EID: 84868013039     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-012-0146-5     Document Type: Review
Times cited : (9)

References (45)
  • 1
    • 0036569980 scopus 로고    scopus 로고
    • Epidemiology of obstructive sleep apnea: a population health perspective
    • May 1 [cited 2012 Jun 5], Available from
    • Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. American journal of respiratory and critical care medicine [Internet]. 2002 May 1 [cited 2012 Jun 5]; 165(9): 1217-39. Available from: http://www. ncbi. nlm. nih. gov/pubmed/11991871.
    • (2002) American journal of respiratory and critical care medicine [Internet] , vol.165 , Issue.9 , pp. 1217-1239
    • Young, T.1    Peppard, P.E.2    Gottlieb, D.J.3
  • 2
    • 33747462560 scopus 로고    scopus 로고
    • Practice parameters for the medical therapy of obstructive sleep apnea
    • Aug, Available from
    • Morgenthaler TI, Kapen S, Lee-Chiong T, Alessi C, Boehlecke B, Brown T, et al. Practice parameters for the medical therapy of obstructive sleep apnea. Sleep [Internet]. 2006 Aug; 29(8): 1031-5. Available from: http://www. ncbi. nlm. nih. gov/pubmed/16944671.
    • (2006) Sleep [Internet] , vol.29 , Issue.8 , pp. 1031-1035
    • Morgenthaler, T.I.1    Kapen, S.2    Lee-Chiong, T.3    Alessi, C.4    Boehlecke, B.5    Brown, T.6
  • 3
    • 79751518990 scopus 로고    scopus 로고
    • The effect of CPAP in normalizing daytime sleepiness, quality of life, and neurocognitive function in patients with moderate to severe OSA
    • Jan [cited 2012 Aug 13], Available from
    • Antic NA, Catcheside P, Buchan C, Hensley M, Naughton MT, Rowland S, et al. The effect of CPAP in normalizing daytime sleepiness, quality of life, and neurocognitive function in patients with moderate to severe OSA. Sleep [Internet]. 2011 Jan [cited 2012 Aug 13]; 34(1): 111-9. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=3001789&tool=pmcentrez&rendertype=abstract.
    • (2011) Sleep [Internet] , vol.34 , Issue.1 , pp. 111-119
    • Antic, N.A.1    Catcheside, P.2    Buchan, C.3    Hensley, M.4    Naughton, M.T.5    Rowland, S.6
  • 5
    • 0034959062 scopus 로고    scopus 로고
    • Reduction in motor vehicle collisions following treatment of sleep apnoea with nasal CPAP
    • BMJ Publishing Group Ltd and British Thoracic Society, Jul 1 [cited 2012 Aug 13], Available from
    • George CFP. Reduction in motor vehicle collisions following treatment of sleep apnoea with nasal CPAP. Thorax [Internet]. BMJ Publishing Group Ltd and British Thoracic Society; 2001 Jul 1 [cited 2012 Aug 13]; 56(7): 508-12. Available from: http://thorax. bmj. com/content/56/7/508. full.
    • (2001) Thorax [Internet] , vol.56 , Issue.7 , pp. 508-512
    • George, C.F.P.1
  • 6
    • 78649894141 scopus 로고    scopus 로고
    • Continuous positive airway pressure reduces risk of motor vehicle crash among drivers with obstructive sleep apnea: systematic review and meta-analysis
    • Oct [cited 2012 Aug 13], Available from
    • Tregear S, Reston J, Schoelles K, Phillips B. Continuous positive airway pressure reduces risk of motor vehicle crash among drivers with obstructive sleep apnea: systematic review and meta-analysis. Sleep [Internet]. 2010 Oct [cited 2012 Aug 13]; 33(10): 1373-80. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=2941424&tool=pmcentrez&rendertype=abstract.
    • (2010) Sleep [Internet] , vol.33 , Issue.10 , pp. 1373-1380
    • Tregear, S.1    Reston, J.2    Schoelles, K.3    Phillips, B.4
  • 8
    • 84964473140 scopus 로고    scopus 로고
    • Continuous positive airway pressure devices for the treatment of obstructive sleep apnoea-hypopnoea syndrome: a systematic review and economic analysis
    • Jan [cited 2012 Aug 13], Available from
    • McDaid C, Griffin S, Weatherly H, Durée K, van der Burgt M, van Hout S, et al. Continuous positive airway pressure devices for the treatment of obstructive sleep apnoea-hypopnoea syndrome: a systematic review and economic analysis. Health technology assessment (Winchester, England) [Internet]. 2009 Jan [cited 2012 Aug 13]; 13(4): iii-iv, xi-xiv, 1-119, 143-274. Available from: http://www. ncbi. nlm. nih. gov/pubmed/19103134.
    • (2009) Health technology assessment (Winchester, England) [Internet] , vol.13 , Issue.4
    • McDaid, C.1    Griffin, S.2    Weatherly, H.3    Durée, K.4    van der Burgt, M.5    van Hout, S.6
  • 9
    • 0027476448 scopus 로고
    • Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea
    • Apr [cited 2012 Jun 5], Available from
    • Kribbs NB, Pack AI, Kline LR, Smith PL, Schwartz AR, Schubert NM, et al. Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea. The American review of respiratory disease [Internet]. 1993 Apr [cited 2012 Jun 5]; 147(4): 887-95. Available from: http://www. ncbi. nlm. nih. gov/pubmed/8466125.
    • (1993) The American review of respiratory disease [Internet] , vol.147 , Issue.4 , pp. 887-895
    • Kribbs, N.B.1    Pack, A.I.2    Kline, L.R.3    Smith, P.L.4    Schwartz, A.R.5    Schubert, N.M.6
  • 10
    • 0036173974 scopus 로고    scopus 로고
    • Long-term compliance rates to continuous positive airway pressure in obstructive sleep apnea: a population-based study
    • Feb [cited 2012 Jun 5], Available from
    • Sin DD, Mayers I, Man GCW, Pawluk L. Long-term compliance rates to continuous positive airway pressure in obstructive sleep apnea: a population-based study. Chest [Internet]. 2002 Feb [cited 2012 Jun 5]; 121(2): 430-5. Available from: http://www. ncbi. nlm. nih. gov/pubmed/11834653.
    • (2002) Chest [Internet] , vol.121 , Issue.2 , pp. 430-435
    • Sin, D.D.1    Mayers, I.2    Man, G.C.W.3    Pawluk, L.4
  • 12
    • 84868137997 scopus 로고    scopus 로고
    • Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses
    • Jan, Available from
    • Ip S, D'Ambrosio C, Patel K, Obadan N, Kitsios GD, Chung M, et al. Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses. Systematic reviews [Internet]. 2012 Jan; 1(1): 20. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=3351715&tool=pmcentrez&rendertype=abstract.
    • (2012) Systematic reviews [Internet] , vol.1 , Issue.1 , pp. 20
    • Ip, S.1    D'Ambrosio, C.2    Patel, K.3    Obadan, N.4    Kitsios, G.D.5    Chung, M.6
  • 15
    • 37549016362 scopus 로고    scopus 로고
    • Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007
    • Jan, Available from
    • Morgenthaler TI, Aurora RN, Brown T, Zak R, Alessi C, Boehlecke B, et al. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. An American Academy of Sleep Medicine report. Sleep [Internet]. 2008 Jan; 31(1): 141-7. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=2225554&tool=pmcentrez&rendertype=abstract.
    • (2008) An American Academy of Sleep Medicine report. Sleep [Internet] , vol.31 , Issue.1 , pp. 141-147
    • Morgenthaler, T.I.1    Aurora, R.N.2    Brown, T.3    Zak, R.4    Alessi, C.5    Boehlecke, B.6
  • 16
    • 77954357784 scopus 로고    scopus 로고
    • Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome
    • Jul [cited 2012 Jun 5], Available from
    • Prasad B, Radulovacki M, Olopade C, Herdegen JJ, Logan T, Carley DW. Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome. Sleep [Internet]. 2010 Jul [cited 2012 Jun 5]; 33(7): 982-9. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=2894441&tool=pmcentrez&rendertype=abstract.
    • (2010) Sleep [Internet] , vol.33 , Issue.7 , pp. 982-989
    • Prasad, B.1    Radulovacki, M.2    Olopade, C.3    Herdegen, J.J.4    Logan, T.5    Carley, D.W.6
  • 18
    • 0026347853 scopus 로고
    • Response of obstructive sleep apnea to fluoxetine and protriptyline
    • Aug [cited 2012 Jun 5], Available from
    • Hanzel DA, Proia NG, Hudgel DW. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest [Internet]. 1991 Aug [cited 2012 Jun 5]; 100(2): 416-21. Available from: http://www. ncbi. nlm. nih. gov/pubmed/1864117.
    • (1991) Chest [Internet] , vol.100 , Issue.2 , pp. 416-421
    • Hanzel, D.A.1    Proia, N.G.2    Hudgel, D.W.3
  • 19
    • 33846227045 scopus 로고    scopus 로고
    • Efficacy of mirtazapine in obstructive sleep apnea syndrome
    • Jan [cited 2012 Jun 6], Available from
    • Carley DW, Olopade C, Ruigt GS, Radulovacki M. Efficacy of mirtazapine in obstructive sleep apnea syndrome. Sleep [Internet]. 2007 Jan [cited 2012 Jun 6]; 30(1): 35-41. Available from: http://www. ncbi. nlm. nih. gov/pubmed/17310863.
    • (2007) Sleep [Internet] , vol.30 , Issue.1 , pp. 35-41
    • Carley, D.W.1    Olopade, C.2    Ruigt, G.S.3    Radulovacki, M.4
  • 20
    • 44949217822 scopus 로고    scopus 로고
    • Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea
    • Jun [cited 2012 Jun 6], Available from
    • Marshall NS, Yee BJ, Desai AV, Buchanan PR, Wong KKH, Crompton R, et al. Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea. Sleep [Internet]. 2008 Jun [cited 2012 Jun 6]; 31(6): 824-31. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=2442407&tool=pmcentrez&rendertype=abstract.
    • (2008) Sleep [Internet] , vol.31 , Issue.6 , pp. 824-831
    • Marshall, N.S.1    Yee, B.J.2    Desai, A.V.3    Buchanan, P.R.4    Wong, K.K.H.5    Crompton, R.6
  • 21
    • 0025071628 scopus 로고
    • Treatment of obstructive sleep apnea. A preliminary report comparing nasal CPAP to nasal oxygen in patients with mild OSA
    • Aug [cited 2012 Jun 6], Available from
    • Phillips BA, Schmitt FA, Berry DT, Lamb DG, Amin M, Cook YR. Treatment of obstructive sleep apnea. A preliminary report comparing nasal CPAP to nasal oxygen in patients with mild OSA. Chest [Internet]. 1990 Aug [cited 2012 Jun 6]; 98(2): 325-30. Available from: http://www. ncbi. nlm. nih. gov/pubmed/2198135.
    • (1990) Chest [Internet] , vol.98 , Issue.2 , pp. 325-330
    • Phillips, B.A.1    Schmitt, F.A.2    Berry, D.T.3    Lamb, D.G.4    Amin, M.5    Cook, Y.R.6
  • 22
    • 0025373856 scopus 로고
    • Preliminary findings in the treatment of obstructive sleep apnea with transtracheal oxygen
    • Apr [cited 2012 Jun 5], Available from
    • Chauncey JB, Aldrich MS. Preliminary findings in the treatment of obstructive sleep apnea with transtracheal oxygen. Sleep [Internet]. 1990 Apr [cited 2012 Jun 5]; 13(2): 167-74. Available from: http://www. ncbi. nlm. nih. gov/pubmed/2184489.
    • (1990) Sleep [Internet] , vol.13 , Issue.2 , pp. 167-174
    • Chauncey, J.B.1    Aldrich, M.S.2
  • 23
    • 0035202831 scopus 로고    scopus 로고
    • Treatment of hypoxemia in obstructive sleep apnea
    • [cited 2012 Jun 6], Available from
    • Landsberg R, Friedman M, Ascher-Landsberg J. Treatment of hypoxemia in obstructive sleep apnea. American journal of rhinology [Internet]. [cited 2012 Jun 6]; 15(5): 311-3. Available from: http://www. ncbi. nlm. nih. gov/pubmed/11732817.
    • American journal of rhinology [Internet] , vol.15 , Issue.5 , pp. 311-313
    • Landsberg, R.1    Friedman, M.2    Ascher-Landsberg, J.3
  • 24
    • 38349153331 scopus 로고    scopus 로고
    • Armodafinil improves wakefulness and long-term episodic memory in nCPAP-adherent patients with excessive sleepiness associated with obstructive sleep apnea
    • Mar [cited 2012 Jun 6], Available from
    • Roth T, Rippon GA, Arora S. Armodafinil improves wakefulness and long-term episodic memory in nCPAP-adherent patients with excessive sleepiness associated with obstructive sleep apnea. Sleep & breathing = Schlaf & Atmung [Internet]. 2008 Mar [cited 2012 Jun 6]; 12(1): 53-62. Available from: http://www. researchgate. net/publication/5969225_Armodafinil_improves_wakefulness_and_long-term_e pisodic_memory_in_nCPAP-adherent_patients_with_excessive_sleepiness_asso ciated_with_obstructive_sleep_apnea.
    • (2008) Sleep & breathing = Schlaf & Atmung [Internet] , vol.12 , Issue.1 , pp. 53-62
    • Roth, T.1    Rippon, G.A.2    Arora, S.3
  • 25
    • 34249814318 scopus 로고    scopus 로고
    • Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning
    • Jun [cited 2012 Jun 6], Available from
    • Weaver TE, Maislin G, Dinges DF, Bloxham T, George CFP, Greenberg H, et al. Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning. Sleep [Internet]. 2007 Jun [cited 2012 Jun 6]; 30(6): 711-9. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=1978355&tool=pmcentrez&rendertype=abstract.
    • (2007) Sleep [Internet] , vol.30 , Issue.6 , pp. 711-719
    • Weaver, T.E.1    Maislin, G.2    Dinges, D.F.3    Bloxham, T.4    George, C.F.P.5    Greenberg, H.6
  • 26
    • 33846652856 scopus 로고    scopus 로고
    • Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome
    • Mar 1 [cited 2012 Apr 13], Available from
    • Hirshkowitz M, Black JE, Wesnes K, Niebler G, Arora S, Roth T. Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome. Respiratory medicine [Internet]. 2007 Mar 1 [cited 2012 Apr 13]; 101(3): 616-27. Available from: http://www. resmedjournal. com/article/S0954-6111(06)00315-5/abstract.
    • (2007) Respiratory medicine [Internet] , vol.101 , Issue.3 , pp. 616-627
    • Hirshkowitz, M.1    Black, J.E.2    Wesnes, K.3    Niebler, G.4    Arora, S.5    Roth, T.6
  • 27
    • 84879787047 scopus 로고    scopus 로고
    • Vivus. No Title. 2012
    • Vivus. No Title. 2012.
  • 28
    • 84862582505 scopus 로고    scopus 로고
    • Anti-Obesity Drugs: A Review about Their Effects and Safety
    • Feb [cited 2012 Jun 6], Available from
    • Kang JG, Park C-Y. Anti-Obesity Drugs: A Review about Their Effects and Safety. Diabetes & metabolism journal [Internet]. 2012 Feb [cited 2012 Jun 6]; 36(1): 13-25. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=3283822&tool=pmcentrez&rendertype=abstract.
    • (2012) Diabetes & metabolism journal [Internet] , vol.36 , Issue.1 , pp. 13-25
    • Kang, J.G.1    Park, C.-Y.2
  • 29
    • 84862777611 scopus 로고    scopus 로고
    • What is the prognosis for new centrally-acting anti-obesity drugs?
    • Jan 30 [cited 2012 Jun 5]; Available from
    • Heal DJ, Gosden J, Smith SL. What is the prognosis for new centrally-acting anti-obesity drugs? Neuropharmacology [Internet]. 2012 Jan 30 [cited 2012 Jun 5]; Available from: http://www. ncbi. nlm. nih. gov/pubmed/22313529.
    • (2012) Neuropharmacology [Internet]
    • Heal, D.J.1    Gosden, J.2    Smith, S.L.3
  • 31
    • 0022628755 scopus 로고
    • The effects of posture on obstructive sleep apnea
    • Apr [cited 2012 Jun 5], Available from
    • McEvoy RD, Sharp DJ, Thornton AT. The effects of posture on obstructive sleep apnea. The American review of respiratory disease [Internet]. 1986 Apr [cited 2012 Jun 5]; 133(4): 662-6. Available from: http://www. ncbi. nlm. nih. gov/pubmed/3963630.
    • (1986) The American review of respiratory disease [Internet] , vol.133 , Issue.4 , pp. 662-666
    • McEvoy, R.D.1    Sharp, D.J.2    Thornton, A.T.3
  • 36
    • 5044242948 scopus 로고    scopus 로고
    • Bariatric surgery: A systematic review and meta-analysis. JAMA?: The journal of the American Medical Association [Internet]
    • Oct 13 [cited 2012 Mar 10], Available from
    • Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA?: the journal of the American Medical Association [Internet]. 2004 Oct 13 [cited 2012 Mar 10]; 292(14): 1724-37. Available from: http://www. ncbi. nlm. nih. gov/pubmed/15479938.
    • (2004) , vol.292 , Issue.14 , pp. 1724-1737
    • Buchwald, H.1    Avidor, Y.2    Braunwald, E.3    Jensen, M.D.4    Pories, W.5    Fahrbach, K.6
  • 38
    • 32544439238 scopus 로고    scopus 로고
    • Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial
    • Feb 4 [cited 2012 Mar 11], Available from
    • Puhan M, Suarez A, Lo Cascio C, Zahn A, Heitz M, Braendli O. Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial. BMJ (Clinical research ed.) [Internet]. 2006 Feb 4 [cited 2012 Mar 11]; 332(7536): 266-70. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=1360393&tool=pmcentrez&rendertype=abstract.
    • (2006) BMJ (Clinical research ed.) [Internet] , vol.332 , Issue.7536 , pp. 266-270
    • Puhan, M.1    Suarez, A.2    Lo Cascio, C.3    Zahn, A.4    Heitz, M.5    Braendli, O.6
  • 40
    • 67349188872 scopus 로고    scopus 로고
    • Risk of sleep apnea in orchestra members
    • Elsevier B. V, Jul [cited 2012 May 31], Available from
    • Brown DL, Zahuranec DB, Majersik JJ, Wren P a, Gruis KL, Zupancic M, et al. Risk of sleep apnea in orchestra members. Sleep medicine [Internet]. Elsevier B. V.; 2009 Jul [cited 2012 May 31]; 10(6): 657-60. Available from: http://www. ncbi. nlm. nih. gov/pubmed/19014898.
    • (2009) Sleep medicine [Internet] , vol.10 , Issue.6 , pp. 657-660
    • Brown, D.L.1    Zahuranec, D.B.2    Majersik, J.J.3    Wren, P.4    Gruis, K.L.5    Zupancic, M.6
  • 41
    • 0033806477 scopus 로고    scopus 로고
    • Effect of Nasal-Valve Dilation on Obstructive Sleep Apnea
    • Sep 1 [cited 2012 May 31], Available from
    • Schonhofer B. Effect of Nasal-Valve Dilation on Obstructive Sleep Apnea. Chest [Internet]. 2000 Sep 1 [cited 2012 May 31]; 118(3): 587-90. Available from: http://www. chestjournal. org/cgi/doi/10. 1378/chest. 118. 3. 587.
    • (2000) Chest [Internet] , vol.118 , Issue.3 , pp. 587-590
    • Schonhofer, B.1
  • 43
    • 79953652107 scopus 로고    scopus 로고
    • A novel nasal expiratory positive airway pressure (EPAP) device for the treatment of obstructive sleep apnea: a randomized controlled trial
    • Apr [cited 2012 May 8], Available from
    • Berry RB, Kryger MH, Massie CA. A novel nasal expiratory positive airway pressure (EPAP) device for the treatment of obstructive sleep apnea: a randomized controlled trial. Sleep [Internet]. 2011 Apr [cited 2012 May 8]; 34(4): 479-85. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artid=3065258&tool=pmcentrez&rendertype=abstract.
    • (2011) Sleep [Internet] , vol.34 , Issue.4 , pp. 479-485
    • Berry, R.B.1    Krauer, M.H.2    Massie, C.A.3
  • 44
    • 77951952094 scopus 로고    scopus 로고
    • Electrical stimulation of the hypoglossal nerve in the treatment of obstructive sleep apnea
    • Oct [cited 2012 Mar 22], Available from
    • Kezirian EJ, Boudewyns A, Eisele DW, Schwartz AR, Smith PL, van de Heyning PH, et al. Electrical stimulation of the hypoglossal nerve in the treatment of obstructive sleep apnea. Sleep medicine reviews [Internet]. 2010 Oct [cited 2012 Mar 22]; 14(5): 299-305. Available from: http://www. ncbi. nlm. nih. gov/pubmed/20116305.
    • (2010) Sleep medicine reviews [Internet] , vol.14 , Issue.5 , pp. 299-305
    • Kezirian, E.J.1    Boudewyns, A.2    Eisele, D.W.3    Schwartz, A.R.4    Smith, P.L.5    van de Heyning, P.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.