Substandard artemisinin-based antimalarial medicines in licensed retail pharmaceutical outlets in Ghana

Journal of Vector Borne Diseases

Volumn 49, Issue 3, 2012, Pages 131-139

  El Duah, M ^a   Ofori Kwakye, K ^a  

^a KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

Author keywords

Artemisinin based combination therapy; Artesunate monotherapy; Counterfeit antimalarials; Substandard antimalarials

Indexed keywords

AMODIAQUINE; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ DERIVATIVE; ARTESUNATE; COUNTERFEIT DRUG;

ANALYTICAL PARAMETERS; ARTICLE; AUTHENTICITY; COLORIMETRY; CONTROLLED STUDY; CRUSHING STRENGTH; DRUG QUALITY; DRUG SURVEILLANCE PROGRAM; DRUG UNDERDOSE; INDIA; PERCENTAGE CONTENT OF ACTIVE PHARMACEUTICAL INGREDIENT; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REGISTRATION; SHELF LIFE; SUBSTANDARD QUALITY; TABLET DISINTEGRATION TIME; TABLET MASS; TABLET PROPERTY; THIN LAYER CHROMATOGRAPHY; UNIFORMITY OF MASS;

AMODIAQUINE; ANTIMALARIALS; ARTEMISININS; CHEMISTRY TECHNIQUES, ANALYTICAL; DRUG AND NARCOTIC CONTROL; DRUG EVALUATION; DRUG INDUSTRY; GHANA; PHARMACEUTICAL PREPARATIONS; PHARMACIES; QUALITY CONTROL;

EID: 84868012581     PISSN: 09729062     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Attaran A, Barnes KI, Curtis C, d'Alessandro U, Fanello CI, Galinski MR, et al. WHO, the global fund and medical malpractice in malaria treatment. Lancet 2004; 363(9404): 237-40
2. Counterfeit drugs - Guidelines for the development of measures to combat counterfeit drugs. Geneva, Switzerland: Department of Essential Drugs and other Medicines, WHO; 1999: p. 1-62
3. Kaur H, Goodman C, Thompson E, Thompson KA, Masanja I, Kachur SP, et al. A nationwide survey of the quality of antimalarials in retail outlets in Tanzania. PLoS ONE 3(10):e3403. doi: 10.1371/journal.pone.003403
4. Gibson L. Drug regulators study global treaty to tackle counterfeit drugs. Br Med J 2004; 328: 486
5. Morris J, Stevens P. Counterfeit medicines in less developed countries - problems and solutions. London: International Policy Network 2006
6. Dondorp AM, Newton PN, Mayxay M, van Damme W, Smithuis FM, Yeung S, et al. Fake antimalarials in Southeast Asia are a major impediment to malaria control: Multinational cross-sectional survey on the prevalence of fake antimalarials. Trop Med Int Health 2004; 9: 1241-6
7. Esimone CO, Okoye FBC, Onah BU, Nworu CS, Omeje EO. In vitro bioequivalence study of nine brands of artesunate tablets marketed in Nigeria. J Vector Borne Dis 2008; 45: 60-5
8. Ofori-Kwakye K, Asantewaa Y, Gaye O. Quality of artesunate tablets sold in pharmacies in Kumasi, Ghana. Trop J Pharm Res 2008; 7(4): 1179-84
9. Osei-Safo D, Harrison JJEK, Addae-Mensah I. Validation and application of quality assurance methods developed for artemisinin-based antimalarial drugs to assess the quality of a selection of such drugs distributed in Accra, Ghana. African J Pharmaceutical Sci Pharma 2010; 1(1): 1-25
10. Tipke M, Diallo S, Coulibaly B, Störzinger D, Hoppe-Tichy T, Sie A, et al. Substandard antimalarial drugs in Burkina Faso. Malar J 2008; 7: 95
11. Atemnkeng MA, De Cock K, Plaizier-Vercammen J. Quality control of active ingredients in artemisinin-derivative antimalarials within Kenya and DR Congo. Trop Med Int Health 2007; 12(1): 68-74
12. Newton PN, McGready R, Fernández FM, Green MD, Sunjio M, Bruneton C, et al. Manslaughter by fake artesunate in Asia: Will Africa be next? PLoS Med 2006; 3(6): e197. doi: 10.1371/ journal.pmed.0030197
13. Bate R, Coticelli P, Tren R, Attaran A. Antimalarial drug quality in the most severely malarious parts of Africa - a six country study. PLoS ONE 2008; 3(5): e2132. doi: 10.1371/journal.pone.002132
14. Hall KA, Newton PN, Green MD, De Veij M, Vandenabeele P, Pizzanelli D, et al. Characterisation of counterfeit artesunate antimalarial tablets from South East Asia. Am J Trop Med Hyg 2006; 75(5): 804-11
15. Newton PN, Dondorp A, Green M, Mayxay M, White NJ. Counterfeit artesunate antimalarials in Southeast Asia. Lancet 2003; 362(9378): 169
16. Rozendaal J. Fake antimalaria drugs in Cambodia. Lancet 2001; 357(9259): 890
17. Green MD, Mount DL, Wirtz RA, White NJ. A colorimetric field method to assess the authenticity of drugs sold as the antimalarial artesunate. J Pharm Biomed Anal 2000; 24: 65-70
18. Ioset JR, Kaur H. Simple field assays to check quality of current artemisinin-based antimalarial combination formulations. PLoS ONE 2009; 4(9): e7270. doi: 10.1371/journal.pone.0007270
19. United States Pharmacopoeia and National Formulary. USP29- NF24 2010; p. 155
20. International Pharmacopoeia. Monographs for antimalarial drugs, v. 5. III edn. Geneva: World Health Organization 2003; p. 185-234
21. Shrivastava A, Nagori BP, Saini P, Issarani R, Gaur SS. New simple and economical spectrophotometric method for estimation of artemether in pharmaceutical dosage forms. Asian J Res Chem 2008; 1(1): 19-21
22. da Costa César I, Nogueira FH, Pianetti GA. Comparison of HPLC, UV spectrophotometry and potentiometric titration methods for the determination of lumefantrine in pharmaceutical products. J Pharm Biomed Anal 2008; 48(1): 223-6
23. Awofisayo SO, Willie E, Umoh E. Quality control evaluation of multi-source artemether-lumefantrine tablets prescribed for uncomplicated multi-drug resistant malaria. Indian J Novel Drug Delivery 2010; 2(4): 153-7
24. Caudron JM, Ford N, Henkens M, Macé C, Kiddle-Monroe R, Pinel J. Substandard medicines in resource-poor settings: A problem that can no longer be ignored. Trop Med Int Health 2008; 13(8): 1062-72
25. Senior K. Global health-care implications of substandard medicines. Lancet Infect Dis 2008; 8(11): 666
26. Newton PN, Green MD, Fernández FM. Impact of poor-quality medicines in the 'developing' world. Trends Pharmacol Sci 2010; 31(3): 99-101