Significant differences in coeliac immunotoxicity of barley varieties

Molecular Nutrition and Food Research

Volumn 56, Issue 11, 2012, Pages 1697-1707

  Comino, Isabel ^a   Real, Ana ^a   Gil Humanes, Javier ^b   Pistón, Fernando ^b   de Lorenzo, Laura ^c   Moreno, Ma de Lourdes ^a   López Casado, Miguel Ángel ^d   Lorite, Pedro ^e   Cebolla, Ángel ^f   Torres, Ma Isabel ^e   Barro, Francisco ^b   Sousa, Carolina ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b INSTITUTO DE AGRICULTURA SOSTENIBLE   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^e Campus Universitario Las Lagunillas   (Spain)

^f Biomedal SL   (Spain)

Author keywords

33 mer; Barley; Coeliac disease; Interferon gamma; Monoclonal antibody

Indexed keywords

EPITOPE; GAMMA INTERFERON; GLIADIN; GLUTEN; PHENYLPROPANOLAMINE;

ADOLESCENT; AMINO ACID SEQUENCE; ARTICLE; BIOPSY; CASE CONTROL STUDY; CELIAC DISEASE; CELL PROLIFERATION; CHILD; FEMALE; HORDEUM; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MOLECULAR GENETICS; ORGAN CULTURE TECHNIQUE; PRESCHOOL CHILD; SMALL INTESTINE;

ADOLESCENT; AMINO ACID SEQUENCE; BIOPSY; CASE-CONTROL STUDIES; CELIAC DISEASE; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; EPITOPES; FEMALE; GLIADIN; GLUTENS; HORDEUM; HUMANS; INTERFERON-GAMMA; INTESTINE, SMALL; MALE; MOLECULAR SEQUENCE DATA; ORGAN CULTURE TECHNIQUES; PHENYLPROPANOLAMINE;

AVENA; HORDEUM; HORDEUM VULGARE SUBSP. SPONTANEUM; SECALE CEREALE; TRITICUM AESTIVUM;

EID: 84867977505     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200358     Document Type: Article

References (52)

1. Baik, B. K., Ullrich, S. E., Barley for food: characteristics, improvement, and renewed interest. J. Cereal Sci. 2008, 48, 304-318.
2. Finnie, C., Svensson, B., Barley seed proteomics from spots to structures. J. Proteomics 2009, 72, 315-324.
3. Sollid, L. M., Coeliac disease: dissecting a complex inflammatory disorder. Nat. Rev. Immunol. 2002, 2, 647-655.
4. Arentz-Hansen, H., Fleckenstein, B., Molberg, Ø., Scott, H. et al., The molecular basis for oat intolerance in patients with celiac disease. PLoS Medic. 2004, 1, 84-92.
5. Comino, I., Real, A., de Lorenzo, L., Cornell, H. et al., Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease. Gut 2011, 60, 915-920.
6. Fasano, A., Clinical presentation of celiac disease in the pediatric population. Gastroenterol. 2005, 128, S68-S73.
7. Sollid, L. M., Markussen, G., Ek, J., Gjerde, H. et al., Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J. Exp. Med. 1989, 169, 345-350.
8. Lundin, K. E., Scott, H., Hansen, T., Paulsen, G. et al., Gliadin-specific, HLA-DQ (alpha 1*0501, beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J. Exp. Med. 1993, 178, 187-196.
9. Sollid, L. M., Khosla, C., Novel therapies for coeliac disease. J. Intern. Med. 2011, 269, 604-613.
10. Marsh, M. N., Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterol. 1992, 102, 330-354.
11. Kim, C. Y., Quarsten, H., Bergseng, E., Khosla, C., Sollid, L. M., Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc. Natl. Acad. Sci. USA 2004, 101, 4175-4179.
12. Sjöström, H., Lundin, K. E., Molberg, O., Körner, R. et al., Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition. Scand. J. Immunol. 1998, 48, 111-115.
13. Vader, W., Kooy, Y., Van Veelen, P., De Ru, A. et al., The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. Gastroenterol. 2002, 122, 1729-1737.
14. Shan, L., Molberg, Ø., Parrot, I., Hausch, F. et al., Structural basis for gluten intolerance in celiac sprue. Science 2002, 297, 2275-2279.
15. Tye-Din, J. A., Stewart, J. A., Dromey, J. A., Beissbarth, T. et al., Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease. Sci. Transl. Med. 2010, 2, 41ra51.
16. De Palma, G., Nadal, I., Collado, M. C., Sanz, Y., Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects. Br. J. Nutr. 2009, 102, 1154-1160.
17. Tripathi, A., Lammers, K. M., Goldblum, S., Shea-Donohue, T. et al., Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc. Natl. Acad. Sci. USA 2009, 106, 16799-16804.
18. Gil-Humanes, J., Pistón, F., Tollefsen, S., Sollid, L. M. et al., Effective shutdown in the expression of celiac disease-related wheat gliadin T-cell epitopes by RNA interference. Proc. Natl. Acad. Sci. USA 2010, 107, 17023-17028.
19. Daveson, A. J., Jones, D. M., Gaze, S., McSorley, H. et al., Effect of hookworm infection on wheat challenge in celiac disease: a randomised double-blinded placebo controlled trial. PLoS One 2011, 6, e17366.
20. Crespo Perez, L., Castillejo de Villasante, G., Cano Ruiz, A., León, F., Non-dietary therapeutic clinical trials in coeliac disease. Eur. J. Intern. Med. 2012, 23, 9-14.
21. Bernardo, D., Peña, A. S., Developing strategies to improve the quality of life of patients with gluten intolerance in patients with and without coeliac disease. Eur. J. Intern. Med. 2012, 23, 6-8.
22. Saisho, D., Takeda, K., Barley: emergence as a new research material of crop science. Plant Cell Physiol. 2011, 52, 724-727.
23. Mayer, K. F. X., Martis, M., Hedley, P. E., Šimková, H. et al., Unlocking the barley genome by chromosomal and comparative genomics. Plant Cell 2011, 23, 1249-1263.
24. Schulte, D., Close, T. J., Graner, A., Langridge, P. et al., The international barley sequencing consortium -at the threshold of efficient access to the barley genome. Plant Physiol. 2009, 149, 142-147.
25. Morón, B., Cebolla, A., Manyani, H., Álvarez-Maqueda, M. et al., Sensitive detection of cereal fractions that are toxic to celiac disease patients by using monoclonal antibodies to a main immunogenic wheat peptide. Am. J. Clin. Nutr. 2008, 87, 405-414.
26. Morón, B., Bethune, M., Comino, I., Manyani, H. et al., Towards the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide. PloS One 2008, 3, e2294.
27. Ehren, J., Morón, B., Martin, E., Bethune, M. T. et al., A food-grade enzyme preparation with modest gluten detoxification properties. PLoS One 2009, 4, e6313.
28. Bradford, M. M., Rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
29. Hernando, A., Valdés, I., Méndez, E., New strategy for the determination of gliadins in maize- or rice-based foods matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: fractionation of gliadins from maize or rice prolamins by acidic treatment. J. Mass Spectr. 2003, 38, 862-871.
30. Comino, I., Real, A., Vivas, S., Síglez, M. Á. et al., Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces. Am. J. Clin. Nutr. 2012, 95, 670-677.
31. Gass, J., Bethune, M. T., Siegel, M., Spencer, A. et al., Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterol. 2007, 133, 472-480.
32. Molberg, O., Lundin, K. E., Nilsen, E. M., Scott, H. et al., HLA restriction patterns of gliadin- and astrovirus-specific CD4+ T cells isolated in parallel from the small intestine of celiac disease patients. Tissue Antigens 1998, 52, 407-415.
33. Vincentini, O., Borrelli, O., Silano, M., Gazza, L. et al., T-cell response to different cultivars of farro wheat, Triticum turgidum ssp. Dicoccum, in celiac disease patients. Clin. Nutr. 2009, 28, 272-277.
34. Marsh, M. N., Crowe, P. T., Morphology of the mucosal lesion in gluten sensitivity. Baillieres Clin. Gastroenterol. 1995, 9, 273-293.
35. Browning, T. H., Trier, J. S., Organ culture of mucosal biopsies of human small intestine. J. Clin. Invest. 1969, 48, 1423-1432.
36. Martín, A., Álvarez, J. B., Martin, L. M., Barro, F., Ballesteros, J., The development of tritordeum: a novel cereal for food processing. J. Cereal Sci. 1999, 30, 85-95.
37. Álvarez, J. B., Ballesteros, J., Sillero, J. A., Martín, L. M., Tritordeum: a new crop of potential importance in the food industry. Hereditas 1992, 116, 193-197.
38. Qian, Y., Preston, K., Krokhin, O., Mellish, J. et al., Characterization of wheat gluten proteins by HPLC and MALDI TOF mass spectrometry. J. Am. Mass Spectrom. 2008, 19, 1542-1550.
39. Marín, S., Gil-Humanes, J., Hernando, A., Barro, F., Characterization of α/β-, and γ-gliadins in commercial varieties and breeding lines of durum wheat by MALDI-TOF and A-PAGE gels. Biochem. Genet. 2011, 49, 735-747
40. Pistón, F., Dorado, G., Martín, A., Barro, F., Cloning and characterization of a gamma-3 hordein mRNA (cDNA) from Hordeum chilense (Roem. et Schult). Theor. Appl. Genet. 2004, 108, 1359-1365.
41. Pistón, F., Martín, A., Dorado, G., Barro, F., Cloning and molecular characterization of B-hordeins from Hordeum chilense (Roem. et Schult). Theor. Appl. Genet. 2005, 111, 551-560.
42. Kanazin, V., Ananiev, E., Blake, T., Variability among members of the Hor-2 multigene family. Genome 1993, 36, 397-403.
43. Spaenij-Dekking, L., Kooy-Winkelaar, Y., van Veelen, P., Drijfhout, J. W. et al., Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. Gastroenterol. 2005, 129, 797-806.
44. Molberg, O., Uhlen, A. K., Jensen, T., Flaete, N. S. et al., Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease. Gastroenterol. 2005, 128, 393-401.
45. Londei, M., Ciacci, C., Ricciardelli, I., Vacca, L. et al., Gliadin as a stimulator of innate responses in celiac disease. Mol. Immunol. 2005, 42, 913-918.
46. Monteleone, I., Monteleone, G., Del Vecchio Blanco, G., Vavassori, P. et al., Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa. Gut 2004, 53, 1090-1095.
47. Ellis, H. J., Rosen-Bronson, S., O'Reilly, N., Ciclitira, P. J., Measurement of gluten using a monoclonal antibody to a coeliac toxic peptide of A-gliadin. Gut 1998, 43, 190-195.
48. Sturgess, R. P., Day, P., Ellis, H. J., Lundin, K. et al., Wheat peptide challenge in coeliac disease. Lancet 1994, 343, 758-761.
49. Tanner, G. J., Howitt, R. I., Forrester, R. I., Campbell, P. M. et al., Dissecting the T-cell response to hordeins in coeliac disease can develop barley with reduced immunotoxicity. Aliment. Pharmacol. Ther. 2010, 32, 1184-1191.
50. Dostálek, P., Hochel, I., Méndez, E., Hernando, A. et al., Immunochemical determination of gluten in malts and beers. Food Addit. Contam. 2006, 11, 1074-1078.
51. Sollid, L. M., Molecular basis of celiac disease. Annu. Rev. Immunol. 2000, 18, 53-81.
52. Greco, L., Romino, R., Coto, I., Di Cosmo, N. et al., The first large population based twin study of coeliac disease. Gut 2002, 50, 624-628.