Bradyarrhythmias in the Elderly

Clinics in Geriatric Medicine

Volumn 28, Issue 4, 2012, Pages 703-715

  Kumar, Preetham ^a   Kusumoto, Fred M ^a   Goldschlager, Nora ^b,c  

^a MAYO CLINIC   (United States)

^b SAN FRANCISCO GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bradyarrhythmias; Elderly; Management; Sinus node dysfunction

Indexed keywords

THEOPHYLLINE;

AGE DISTRIBUTION; AGED; ARTIFICIAL HEART PACEMAKER; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; CLINICAL EXAMINATION; CLINICAL FEATURE; COGNITION; COMORBIDITY; DEVICE THERAPY; ELDERLY CARE; ELECTROCARDIOGRAM; FOLLOW UP; HEALTH CARE PERSONNEL; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART ATRIUM PACING; HEART BUNDLE BRANCH BLOCK; HEART FAILURE; HEART PACING; HIGH RISK POPULATION; HOSPITALIZATION; HUMAN; IATROGENIC DISEASE; LIFE EXPECTANCY; LIFE EXTENSION; MEDICAL DECISION MAKING; PACEMAKER SYNDROME; PATHOPHYSIOLOGY; PATIENT EDUCATION; PHYSICAL ACTIVITY; PNEUMOTHORAX; PREVALENCE; PROGNOSIS; PSYCHOLOGICAL WELL BEING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMOTE SENSING; REVIEW; RISK BENEFIT ANALYSIS; RISK REDUCTION; SICK SINUS SYNDROME; SINUS NODE DISEASE; SOCIAL ASPECT; SOCIAL SUPPORT; UNITED STATES;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BRADYCARDIA; ELECTROCARDIOGRAPHY; FEMALE; HEART BLOCK; HEART RATE; HUMANS; MALE; MIDDLE AGED; PACEMAKER, ARTIFICIAL; PROGNOSIS; SINOATRIAL NODE;

EID: 84867942298     PISSN: 07490690     EISSN: 18798853     Source Type: Journal    
DOI: 10.1016/j.cger.2012.08.004     Document Type: Review

References (35)

1. United States census data 2010; United States Census Bureau. Available at: Accessed July 20, 2012. http://www.census.gov/2010census/.
2. United Nations, world populations prospects: the 2008 revision (medium scenario). 2009. Available at: Accessed July 20, 2012. http://www.un.org/esa/population/./wpp2008/wpp2008_text_tables.pdf.
3. Brubaker P.H., Kitzman D.W. Chronotropic incompetence: causes, consequences, and management. Circulation 2011, 123(9):1010-1020.
4. Ogawa T., Spina R.J., Martin W.H., et al. Effects of aging, sex, and physical training on cardiovascular responses to exercise. Circulation 1992, 86(2):494-503.
5. Gulati M., Shaw L.J., Thisted R.A., et al. Heart rate response to exercise stress testing in asymptomatic women: the St. James Women Take Heart Project. Circulation 2010, 122:130-137.
6. Bharati S., Lev M. The pathologic changes in the conduction system beyond the age of ninety. Am Heart J 1992, 124(2):486-496.
7. Song Y., Laaksonen H., Saukko P., et al. Histopathological findings of cardiac conduction system of 150 finns. Forensic Sci Int 2001, 119(3):310-317.
8. Kuo C.T., Wu J.M., Lin K.H., et al. The effects of aging on AV nodal recovery properties. Pacing Clin Electrophysiol 2001, 24(2):194-198.
9. Chow L.T., Chow S.S., Anderson R.H., et al. Autonomic innervation of the human cardiac conduction system: changes from infancy to senility-an immunohistochemical and histochemical analysis. Anat Rec 2001, 264(2):169-182.
10. Assar M.D., Krahn A.D., Klein G.J., et al. Optimal duration of monitoring in patients with unexplained syncope. Am J Cardiol 2003, 92:1231-1233.
11. Manolio T.A., Furberg C.D., Rautaharju P.M., et al. Cardiac arrhythmias on 24-hour ambulatory electrocardiography in older women and men: the Cardiovascular Health Study. J Am Coll Cardiol 1994, 23:916-925.
12. Wakida Y., Okamoto Y., Iwa T., et al. Arrhythmias in centenarians. Pacing Clin Electrophysiol 1994, 17(11 Pt 2):2217-2221.
13. Craft N., Schwartz J.B. Effects of age on intrinsic heart rate, heart rate variability, and AV conduction in healthy humans. Am J Physiol 1995, 268(4 Pt 2):H1441-H1452.
14. Eriksson P., Hansson P.O., Eriksson H., et al. Bundle-branch block in a general male population: the study of men born 1913. Circulation 1998, 98:2494-2500.
15. Fahy G.J., Pinski S.L., Miller D.P., et al. Natural history of isolated bundle branch block. Am J Cardiol 1996, 77:1185-1190.
16. Kreger B.E., Anderson K.M., Kannel W.B. Prevalence of intra-ventricular block in the general population. The Framingham Study. Am Heart J 1989, 117:903-910.
17. Gill S.S., Anderson G.M., Fischer H.D., et al. Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study. Arch Intern Med 2009, 169(9):867-873.
18. Dungen H.D., Apostolovic S., Inkrot S., et al. Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD Trial. Eur J Heart Fail 2011, 13:670-680.
19. Goldschlager N. Conduction disorders & cardiac pacing. Current diagnosis & treatment: cardiology 2011, 222-227. McGraw Hill, New York. Michael Crawford (Ed.).
20. Kusumoto F.M., Goldschlager N. Cardiac pacing. N Engl J Med 1996, 334(2):89-97.
21. Menozzi C., Brignole M., Alboni P., et al. The natural course of untreated sick sinus syndrome and identification of the variables predictive of unfavorable outcome. Am J Cardiol 1998, 82:1205-1208.
22. Mymin D., Mathewson F.A., Tate R.B., et al. The natural history of primary first-degree atrioventricular heart block. N Engl J Med 1986, 315:1183-1187.
23. Zeltser D., Justo D., Halkin A., et al. Drug-induced atrioventricular block: prognosis after discontinuation of the culprit drug. J Am Coll Cardiol 2004, 44:105-108.
24. Alboni P., Menozzi C., Brignole M., et al. Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial. Circulation 1997, 96(1):260-266.
25. Lamas G.A., Lee K., Sweeney M., et al. The Mode Selection Trial (MOST) in sinus node dysfunction: design, rationale, and baseline characteristics of the first 1000 patients. Am Heart J 2000, 140:541-551.
26. Kerr C.R., Connolly S.J., Abdollah H., et al. Canadian trial of physiological pacing: effects of physiological pacing during long-term follow-up. Circulation 2004, 109:357-362.
27. Nielsen J.C., Thomsen P.O.B., Hojberg S., et al. A comparison of single-lead atrial pacing with dual-chamber pacing in sick sinus syndrome. Eur Heart J 2011, 32:686-696.
28. Toff W.D., Camm A.J., Skehan J.D. Single-chamber versus dual-chamber pacing for high-grade atrioventricular block. N Engl J Med 2005, 353:145-155. UKPACE.
29. Heist E.K., Harthorne J.W., Sinhgh J.P. Pacing for AV block. N Engl J Med 2005, 353:1742-1744.
30. Sweeney M.O., Hellkamp A.S., Ellenbogen K.A., et al. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation 2003, 107:2932-2937.
31. Wilkoff B.L., Cook J.R., Epstein A.E., et al. Dual chamber and VVI implantable defibrillator trial inestigators. JAMA 2002, 288:3115-3123.
32. Link M.S., Estes N.A., Griffin J.J., et al. Complications of dual chamber pacemaker implantation in the elderly. Pacemaker Selection in the Elderly (PASE) investigators. J Interv Card Electrophysiol 1998, 2:175-179.
33. Armaganijan L.V., Toff W.D., Nielsen J.C., et al. Are elderly patients at increased risk of complications following pacemaker implantation? A meta-analysis of randomized trials. Pacing Clin Electrophysiol 2012, 35(2):131-134.
34. Healey J.S., Connolly S.J., Gold M.R., et al. Subclinical atrial fibrillation and the risk of stroke. N Engl J Med 2012, 366(2):120-129. ASSERT Investigators.
35. Crossley G.H., Chen J., Choucair W., et al. Clinical benefits of remote versus transtelephonic monitoring of implanted pacemakers. J Am Coll Cardiol 2009, 54:2012-2019.