Dendritic cells sequester antigenic epitopes for prolonged periods in the absence of antigen-encoding genetic information

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 43, 2012, Pages 17543-17548

  Li, Changying ^a,b   Buckwalter, Matthew R ^a   Basu, Sreyashi ^a   Garg, Manish ^a   Chang, Jiwu ^b   Srivastava, Pramod K ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b SECOND HOSPITAL OF TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Chaperone; Cross presentation; Heat shock protein

Indexed keywords

EPITOPE; HEAT SHOCK PROTEIN 90; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGENICITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GENETIC CODE; IMMUNOSTIMULATION; IN VITRO SELECTION; IN VIVO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL;

ANIMALS; ANTIGENS; DENDRITIC CELLS; EPITOPES; HSP90 HEAT-SHOCK PROTEINS; MICE; MICE, INBRED C57BL;

EID: 84867911430     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205867109     Document Type: Article

References (28)

1. P'ringle C-R, Shirodaria P-V, Cash P, Chiswell D-J, Malloy P (1978) Initiation and maintenance of persistent infection by respiratory syncytial virus. J Virol 28:199-211.
2. Schwarze J, O'Donnell D-R, Rohwedder A, Openshaw P-J (2004) Latency and persistence of respiratory syncytial virus despite T cell immunity. Am J Respir Crit Care Med 169:801-805. (Pubitemid 38402454)
3. Mori I, et al. (1995) Parainfluenza virus type 1 infects olfactory neurons and establishes long-term persistence in the nerve tissue. J Gen Virol 76:1251-1254.
4. Jelley-Gibbs D-M, et al. (2005) Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. J Exp Med 202:697-706.
5. Zammit D-J, Turner D-L, Klonowski K-D, Lefrançois L, Cauley L-S (2006) Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration. Immunity 24:439-449.
6. Turner DL, Cauley LS, Khanna KM, Lefrançois L (2007) Persistent antigen presentation after acute vesicular stomatitis virus infection. J Virol 81:2039-2046. (Pubitemid 46214475)
7. Khanna K-M, et al. (2008) In situ imaging reveals different responses by naïve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection. Eur J Immunol 38:3304-3315.
8. Kim T-S, Hufford M-M, Sun J, Fu Y-X, Braciale T-J (2010) Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection. J Exp Med 207:1161-1172.
9. Fazilleau N, et al. (2007) Lymphoid reservoirs of antigen-specific memory T helper cells. Nat Immunol 8:753-761. (Pubitemid 46965351)
10. Itano A-A, Jenkins M-K (2003) Antigen presentation to naive CD4 T cells in the lymph node. Nat Immunol 4:733-739.
11. Itano A-A, et al. (2003) Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19:47-57.
12. Sixt M, et al. (2005) The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22:19-29. (Pubitemid 40143448)
13. Storkus W-J, Zeh H-J, 3rd, Salter R-D, Lotze M-T (1993) Identification of T-cell epitopes: rapid isolation of class I-presented peptides from viable cells by mild acid elution. J Immunother Emphasis Tumor Immunol 14:94-103.
14. Ishii T, et al. (1999) Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96. J Immunol 162:1303-1309. (Pubitemid 29306999)
15. Kunisawa J, Shastri N (2006) Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway. Immunity 24:523-534. (Pubitemid 43728158)
16. Callahan M-K, Garg M, Srivastava P-K (2008) Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation. Proc Natl Acad Sci USA 105:1662-1667. (Pubitemid 351346571)
17. Imai T, et al. (2011) Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci USA 108:16363-16368.
18. Banerji U, Judson I, Workman P (2003) The clinical applications of heat shock protein inhibitors in cancer - present and future. Curr Cancer Drug Targets 3:385-390. (Pubitemid 37128325)
19. van Montfoort N, et al. (2009) Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity. Proc Natl Acad Sci USA 106:6730-6735.
20. Faure F, et al. (2009) Long-lasting cross-presentation of tumor antigen in human DC. Eur J Immunol 39:380-390.
21. Reboulet R-A, Hennies C-M, Garcia Z, Nierkens S, Janssen E-M (2010) Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime antitumor responses in tumor-bearing mice. J Immunol 185:3337-3347.
22. McCloskey M-L, Curotto de Lafaille M-A, Carroll M-C, Erlebacher A (2011) Acquisition and presentation of follicular dendritic cell-bound antigen by lymph node-resident dendritic cells. J Exp Med 208:135-148.
23. Kamath A-T, Henri S, Battye F, Tough D-F, Shortman K (2002) Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood 100:1734-1741. (Pubitemid 34925152)
24. Geissmann F (2007) The origin of dendritic cells. Nat Immunol 8:558-560.
25. Woodland D-L, Kohlmeier J-E (2009) Migration, maintenance and recall of memory T cells in peripheral tissues. Nat Rev Immunol 9:153-161.
26. Allan R-S, et al. (2006) Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity 25:153-162.
27. Lelouard H, et al. (2002) Transient aggregation of ubiquitinated proteins during dendritic cell maturation. Nature 417:177-182. (Pubitemid 34506798)
28. Taipale M, Jarosz D-F, Lindquist S (2010) HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 11:515-528.