Case report: Treatment of granulomatous amoebic encephalitis with voriconazole and miltefosine in an immunocompetent soldier

American Journal of Tropical Medicine and Hygiene

Volumn 87, Issue 4, 2012, Pages 715-718

  Webster, Duncan ^a   Umar, Imram ^a   Kolyvas, George ^a   Bilbao, Juan ^b   Guiot, Marie Christine ^c   Duplisea, Kevin ^d   Qvarnstrom, Yvonne ^e   Visvesvara, Govinda S ^f  

^a SAINT JOHN REGIONAL HOSPITAL   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d TORONTO WESTERN HOSPITAL   (Canada)

^e NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^f NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; MILTEFOSINE; PARASITE ANTIBODY; PHENYTOIN; VALPROIC ACID; VORICONAZOLE; DRUG DERIVATIVE; PHOSPHORYLCHOLINE; PYRIMIDINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ACANTHAMOEBA; ACANTHAMOEBA ENCEPHALITIS; ADULT; ANTICONVULSANT THERAPY; ANTIMICROBIAL THERAPY; ARTICLE; BRAIN BIOPSY; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CRANIOTOMY; DRUG DOSE REDUCTION; DRUG ERUPTION; DRUG RESPONSE; DRUG WITHDRAWAL; GASTROINTESTINAL SYMPTOM; GRANULOMATOUS AMEBIC ENCEPHALITIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENCE; IMMUNOHISTOCHEMISTRY; KIDNEY DYSFUNCTION; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PSEUDOTUMOR; REAL TIME POLYMERASE CHAIN REACTION; SOLDIER; TINNITUS; TONIC CLONIC SEIZURE; AMEBIASIS; ANIMAL; DRUG EFFECT; ENCEPHALITIS; GRANULOMA; ISOLATION AND PURIFICATION; PARASITOLOGY; TREATMENT OUTCOME;

ACANTHAMOEBA; ADULT; AMEBIASIS; ANIMALS; ENCEPHALITIS; GRANULOMA; HUMANS; IMMUNOCOMPETENCE; MALE; MILITARY PERSONNEL; PHOSPHORYLCHOLINE; PYRIMIDINES; TREATMENT OUTCOME; TRIAZOLES;

EID: 84867908387     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2012.12-0100     Document Type: Article

References (27)

1. Visvesvara GS, Moura H, Schuster FL, 2007. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri and Sappinia diploidea. FEMS Immunol Med 50: 1-26. (Pubitemid 46763469)
2. Schuster FL, Visvesvara GS, 2004. Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals. Int J Parasitol 34: 1001-1027. (Pubitemid 39106843)
3. Abramowicz M (ed), 2007. Drugs for parasitic infections. Treat Guidel Med Lett 5 (Suppl): e1-e15.
4. Singhal T, Bajpai A, Kalra V, Kabra SK, Samantaray JC, Satpathy G, Gupta AK, 2001. Successful treatment of Acanthamoeba meningitis with combination oral antimicrobials. Pediatr Infect Dis J 20: 623-627. (Pubitemid 32567727)
5. Gupta D, Bakhshi S, Panda GS, 2008. Successful treatment of Acanthamoeba meningoencephalitis during induction therapy of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 50: 1292-1293. (Pubitemid 351555572)
6. Saxena A, Mittal S, Burnam P, Garg P, 2009. Acanthamoeba meningitis with successful outcome. Indian J Pediatr 76: 1063-1064.
7. Ofori-Kwakye SK, Sidebottom DG, Herbert J, Fischer EG, Visvesvara GS, 1986. Granulomatous brain tumor caused by Acanthamoeba. J Neurosurg 64: 505-509. (Pubitemid 16035075)
8. Martinez MS, Gonzalez-Mediero G, Santiago P, Rodriguez de Lope A, Diz J, Conde C, Visvesvara GS, 2000. Granulomatous amebic encephalitis in a patient with AIDS: isolation of Acanthamoeba sp. group II from brain tissue and successful treatment with sulfadiazine and fluconazole. J Clin Microbiol 38: 3892-3895.
9. Fung KT, Dhillon AP, McLaughlin JE, Lucas SB, Davidson B, Rolles K, Patch D, Burroughs AK, 2008. Cure of Acanthamoeba cerebral abscess in a liver transplant patient. Liver Transpl 14: 308-312. (Pubitemid 351425484)
10. Aichelburg A, Walochnik J, Assadian O, Prosch H, Steuer A, Perneczky G, Visvesvara GS, Aspöck H, Vetter N, 2008. Successful treatment of disseminated Acanthamoeba sp. infection with miltefosine. Emerg Infect Dis 14: 1743-1746.
11. Siddiqui R, Khan NA, 2012. Biology and pathogenesis of Acanthamoeba. Available at: http://www.parasitesandvectors.com/content/5/1/6. Accessed May 16, 2012.
12. Walochnik J, Aichelburg A, Assadian O, Steuer A, Visvesvara G, Vetter N, Aspöck H, 2008. Granulomatous amoebic encephalitis caused by Acanthamoeba amoebae of genotype T2 in a human immunodeficiency virus-negative patient. J Clin Microbiol 46: 338-340.
13. Pan NR, Ghosh TN, 1971. Primary amoebic meningo-encephalitis in two Indian children. J Indian Med Assoc 56: 134-137.
14. Lalitha MK, Anandi V, Srivastava A, Thomas K, Cherian AM, Chandi SM, 1985. Isolation of Acanthamoeba culbertsoni from a patient with meningitis. J Clin Microbiol 21: 666-667. (Pubitemid 15106539)
15. Karande SC, Lahiri KR, Sheth SS, Nadkarni US, Jain MK, Shah MD, 1991. Acanthamoeba meningoencephalitis complicating pyogenic meningitis. Indian Pediatr 28: 794-797.
16. Sharma PP, Gupta P, Murali MV, Ramachandran VG, 1993. Primary amebic meningoencephalitis caused by Acanthamoeba: successfully treated with cotrimoxazole. Indian Pediatr 30: 1219-1222. (Pubitemid 23314744)
17. Petry F, Torzewski M, Bohl J, Wilhelm-Schwenkmezger T, Scheid P, Walochnik J, Michel R, Zoller L, Werhahn KJ, Bhakdi S, Lackner KJ, 2006. Early diagnosis of Acanthamoeba infection during routine cytological examination of cerebrospinal fluid. J Clin Microbiol 44: 1903-1904. (Pubitemid 43726298)
18. Sheng WH, Hung CC, Huang HH, Liang SY, Cheng YJ, Ji DD, Chang SC, 2009. First case of granulomatous aebic encephalitis caused by Acanthamoeba castellanii in Taiwan. Am J Trop Med Hyg 81: 277-279.
19. Lackner P, Beer R, Broessner G, Helbok R, Pfausler B, Brenneis C, Auer H, Walochnik J, Schmutzhard E, 2010. Acute granulomatous Acanthamoeba encephalitis in an immunocompetent patient. Neurocrit Care 12: 91-94.
20. Maritschnegg P, Sovinz P, Lackner H, Benesch M, Nebl A, Schwinger W, Walochnik J, Urban C, 2011. Granulomatous amebic encephalitis in a child with acute lymphoblastic leukemia successfully treated with multimodal antimicrobial therapy and hyperbaric oxygen. J Clin Microbiol 49: 446-448.
21. Schuster F, Yagi S, Gavali S, Michelson D, Raghaven R, Blomquist I, Glastonbury C, Bollen AW, Scharnhorst D, Reed SL, Kuriyama S, Visvesvara GV, Glaser CA, 2009. Under the radar: Balamuthia amebic encephalitis. Clin Infect Dis 48: 879-887.
22. Schuster FL, Guglielmo BJ, Visvesvara GS, 2006. In vitro activity of miltefosine and voriconazole on clinical isolates of free-living amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri. J Eukaryot Microbiol 53: 121-126. (Pubitemid 43357017)
23. Walochnik J, Duchêne M, Seifert K, Obwaller A, Hottkowitz T, Wiedermann G, Eibl H, Aspöck H, 2002. Cytotoxic activities of alkylphosphocholines against clinical isolates of Acanthamoeba spp. Antimicrob Agents Chemother 46: 695-701. (Pubitemid 34157653)
24. Walia R, Montoya JG, Visvesvera GS, Booton GC, Doyle RL, 2007. Acase of successful treatment of cutaneous Acanthamoeba infection in a lung transplant recipient. Transpl Infect Dis 9: 51-54.
25. Sundar S, Jha TK, Thakur CP, Bhattacharya SK, Rai M, 2002. Oral miltefosine for Indian visceral leishmaniasis. N Engl J Med 347: 1739-1746. (Pubitemid 35375612)
26. Murray HW, 2012. Leishmaniasis in the United States: treatment in 2012. Am J Trop Med Hyg 86: 434-440.
27. Kesson A, Bellemore M, O'Mara T, Ellis D, Sorrell T, 2009. Scedosporium prolificans osteomyelitis in an immunocompetent child treated with a novel agent, hexadecylphosphocholine (miltefosine), in combination with terbinafine and voriconazole: a case report. Clin Infect Dis 48: 1257-1261.