Low dose oxidative stress induces mitochondrial damage in hair cells

Anatomical Record

Volumn 295, Issue 11, 2012, Pages 1868-1876

  Baker, Kim ^a   Staecker, Hinrich ^b  

^a Department of Otolaryngology   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Hair cells; Mitochondria; Oxidative stress

Indexed keywords

CASPASE; HYDROGEN PEROXIDE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DAMAGE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE EXPRESSION; HAIR CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CASPASES; CELLS, CULTURED; ENZYME ACTIVATION; HAIR CELLS, AUDITORY; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; ORGAN OF CORTI; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN BIOSYNTHESIS; REACTIVE OXYGEN SPECIES;

EID: 84867901061     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.22594     Document Type: Article

References (19)

1. Arnaiz SL, Coronel MF, Boveris A. 1999. Nitric Acid, superoxide, and hydrogen peroxide production in brain mitochondria after haloperidol treatment. Nitric Oxide 3: 235-243.
2. Clerici WJ, Hensley K, DiMartino DL, Butterfield DA. 1996. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 98: 116-124.
3. Clerici WJ, Yang L. 1996. Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hear Res 101: 14-22.
4. Dehne N, Lautermann AWJF, Cate A, Rauen U, de Groot H. 2000. In vitro effects of hydrogen peroxide on the cochlear neurosensory epithelium of the guinea pig. Hear Res 143: 162-170.
5. Fiskum G, Murphy AN, Beal MF. 1999. Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases. J Cereb Blood Flow Metab 19: 351-369.
6. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R. 1995. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology 21: 1465-1468.
7. Hoyt KR, Gallagher AJ, Hastings TG, Reynolds IJ. 1997. Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons. Neurochem Res 22: 333-340.
8. Hu BH, Guo W, Wang PY, Henderson D, Jiang SC. 2000. Intense noise induced apoptosis in hair cells of guinea pig cochleae. Acta Otolaryngol 120: 19-24.
9. Hu BH, Henderson D, Nicotera TM. 2002. Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise. Hear Res 166: 62-71.
10. Hu B, Yang WP, Nicotera T, Henderson D. 2003. Mitochondrial functions in apoptotic and necrotic OHCs following exposure to impulse noise. ARO MidWinter Meeting.
11. Jin GF, Hurst JS, Godley BF. 2001. Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells. Curr Eye Res 22: 165-173.
12. Kopke RD, Liu W, Gabaizadeh R, Jacono A, Feghali J, Spray D, Garcia P, Steinman H, Malgrange B, Rubin RJ, Rybak L, Van De Water TR. 1997. Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am J Otol 18: 559-571.
13. Ohinata Y, Miller JM, Altschuler RA, Schacht J. 2000. Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea. Brain Res 878: 163-173.
14. Ohinata Y, Miller JM, Schacht J. 2003. Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea. Brain Res 966: 265-273.
15. Ohlemiller KK, Dugan LL. 1999. Elevation of reactive oxygen species following Ischemia-reperfusion in mouse cochlea observed in vivo. Audiol Neurootol 4: 219-228.
16. Ohlemiller KK, Wright JS, Dugan LL. 1999. Early elevation of cochlear reactive oxygen species following noise exposure. Audiol Neurootol 4: 229-236.
17. Sha SH, Taylor R, Forge A, Schacht J. 2001. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 155: 1-8.
18. Yamashita D, Jiang HY, Miller JM, Schacht J. 2003. Late mergence of free radicals after noise exposure. ARO MidWinter Meeting.
19. Yang WP, Bohne BA, Nicotera T, Henderson D. 2003. Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise. ARO MidWinter Meeting.