Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6923-6928

  Poslusney, Michael S ^a,b   Sevel, Christian ^a,b   Utley, Thomas J ^a,b   Bridges, Thomas M ^a,b   Morrison, Ryan D ^a,b   Kett, Nathan R ^a,b   Sheffler, Douglas J ^a,b   Niswender, Colleen M ^a,b   Daniels, J S ^a,b   Conn, P J ^a,b   Lindsley, Craig W ^a,b   Wood, Michael R ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Fluorination; M1 antagonist; Muscarinic acetylcholine receptor 1; VU0431263; VU0433670

Indexed keywords

ATROPINE; MUSCARINIC M1 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; VU 0431263; VU 0433670;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG BINDING; DRUG COMPETITION; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINE; AMIDES; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; PIPERAZINES; RECEPTOR, MUSCARINIC M1; STEREOISOMERISM; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867890933     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.011     Document Type: Article

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