Flare phenomenon following gefitinib treatment of lung adenocarcinoma with bone metastasis

Tohoku Journal of Experimental Medicine

Volumn 228, Issue 2, 2012, Pages 163-168

  Hashisako, Mikiko ^a   Wakamatsu, Kentarou ^a   Ikegame, Satoshi ^a   Kumazoe, Hiroyuki ^a   Nagata, Nobuhiko ^b   Kajiki, Akira ^a  

^a Omuta National Hospital   (Japan)

^b Fukuoka University Chikushi Hospital   (Japan)

Author keywords

Bone metastasis; Bone scintigraphy; Flare phenomenon; Gefitinib; Lung cancer

Indexed keywords

ALKALINE PHOSPHATASE; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; POLYPHOSPHORIC ACID TC 99M;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BONE METASTASIS; BONE SCINTISCANNING; CANCER CYTODIAGNOSIS; CANCER STAGING; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; EPIDERMAL GROWTH FACTOR RECEPTOR GENE; EXON; HUMAN; HUMAN CELL; LEUKOCYTE COUNT; LUNG ADENOCARCINOMA; MALE; MEDICAL HISTORY; MISSENSE MUTATION; RECEPTOR GENE; SMOKING; SPUTUM CYTODIAGNOSIS; THORAX RADIOGRAPHY; TRIGEMINUS NEURALGIA; TUMOR FLARE; TUMOR VOLUME; WEIGHT REDUCTION;

ADENOCARCINOMA; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENTS; BONE AND BONES; BONE NEOPLASMS; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; POLYPHOSPHATES; QUINAZOLINES; RADIONUCLIDE IMAGING; TECHNETIUM COMPOUNDS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84867884246     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.228.163     Document Type: Article

References (17)

1. Amoroso, V., Pittiani, F., Grisanti, S., Valcamonico, F., Simoncini, E., Ferrari, V.D. & Marini, G. (2007) Osteoblastic flare in a patient with advanced gastric cancer after treatment with pemetrexed and oxaliplatin: implications for response assessment with RECIST crtiteria. BMC Cancer, 7, 94.
2. Arai, Y. & Kojima, A. (2007) A case of lung cancer with alkaline phosphatase flare phenomenon during gefitinib therapy. Nihon Kokyuki Gakkai Zasshi, 45, 962-966.
3. Chao, H.S., Chang, C.P., Chiu, C.H., Chu, L.S., Chen, Y.M. & Tsai, C.M. (2009) Bone scan flare phenomenon in non-small-cell lung cancer patients treated with gefitinib. Clin. Nucl. Med., 34, 346-349.
4. Coleman, R.E., Whitaker, K.B., Moss, D.W., Mashiter, G., Fogelman, I. & Rubens, R.D. (1988) Biochemical prediction of response of bone metastases to treatment. Br. J. Cancer, 58, 205-210.
5. Cosolo, W., Morstyn, G., Arkles, B., Zimet, A.S. & Zalcberg, J.R. (1988) Flare response in small cell carcinoma of the lung. Clin. Nucl. Med., 13, 13-16.
6. Greenberg, E.J., Chu, F.C.H., Dwyer, A.J., Ziminski, E.M., Dimich, A.B. & Laughlin, J.S. (1972) Effects of radiation therapy on bone lesions as measured by 47Ca and 85Sr local kinetics. J. Nucl. Med., 13, 747-751.
7. Killian, C.S., Vargas, F.P., Pontes, E.J., Beckley, S., Slack, N.H., Murphy, G.P. & Chu, T.M. (1981) The use of serum isoenzymes of alkaline and acid phosphatase as possible quantitative markers of tumor load in prostate cancer. Prostate, 2, 187-206.
8. Koizumi, M., Matsumoto, S., Takahashi, S., Yamashita, T. & Ogata, E. (1999) Bone metabolic markers in the evaluation of bone scan flare phenomenon in bone metastases of breast cancer. Clin. Nucl. Med., 1, 15-20.
9. Koizumi, M. (2004) Bone metastasis. THE BONE, 18, 583-586.
10. Krupitskaya, Y., Eslamy, H.K., Nguyen, D.D., Kumar, A. & Wakelee, H.A. (2009) Osteoblastic bone flare on F18-FDG PET in non-small cell lung cancer (NSCLC) patients receiving bevacizumab in addition to standard chemotherapy. J. Thorac. Oncol., 4, 429-431.
11. Lemieux, J., Guimond, J., Laberge, F., St-Pierre, C. & Cormier, Y. (2002) The bone scan flare phenomenon in non-small-cell lung cancer. Clin. Nucl. Med., 27, 486-489.
12. Lind, J.S., Postmus, P.E. & Smit, E.F. (2010) Osteoblastic bone lesions developing during treatment with erlotinib indicate major response in patients with non-small cell lung cancer: a brief report. J. Thorac. Oncol., 5, 554-557.
13. Pluquet, E., Cadranel, J., Legendre, A., Faller, M.B., Souquet, P.J., Zalcman, G., Perol, M., Fraboulet, G., Oliveiro, G., De Fraipont, F., Quoix, E., Lantuejoul, S., Milleron, B. & Moro-Sibilot, D. (2010) Osteoblastic reaction in non-small cell lung carcinoma and its association to epidermal growth factor receptor tyrosine kinase inhibitors response and prolonged survival. J. Thorac. Oncol., 5, 491-496.
14. Pollen, J.J., Witztum, K.F. & Ashburn, W.L. (1984) The flare phenomenon on radionuclide bone scan in metastatic prostate cancer. Am. J. Roentgenol., 4, 773-776.
15. Schumacher, T., Brink, I., Mix, M., Reinhardt, M., Herget, G., Digel, W., Henke, M., Moser, E. & Nitzsche, E. (2001) FDG-PET imaging for the staging and follow-up of small cell lung cancer. Eur. J. Nucl. Med., 28, 483-488.
16. Toloza, E.M., Harpole, L. & McCrory, D.C. (2003) Noninvasive staging of non-small cell lung cancer: a review of the current evidence. Chest, 123, 137S-146S.
17. Vogel, C.L., Schoenfelder, J., Shemano, I., Hayes, D.F. & Gams, R.A. (1995) Worsening bone scan in the evaluation of antitumor response during hormonal therapy of breast cancer. J. Clin. Oncol., 13, 1123-1128.