Indoxyl Sulfate Predicts Cardiovascular Disease and Renal Function Deterioration in Advanced Chronic Kidney Disease

Archives of Medical Research

Volumn 43, Issue 6, 2012, Pages 451-456

  Lin, Cheng Jui ^a,d   Liu, Hsuan Liang ^d   Pan, Chi Feng ^a   Chuang, Chih Kuang ^b,c,d   Jayakumar, Thanasekaran ^a   Wang, Tuen Jen ^e   Chen, Han Hsiang ^a   Wu, Chih Jen ^a  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^e NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY   (Taiwan)

Author keywords

Cardiovascular event; Chronic kidney disease; Dialysis; Indoxyl sulfate

Indexed keywords

CREATININE; INDICAN; PHOSPHATE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; CREATININE BLOOD LEVEL; FEMALE; FOLLOW UP; HEMODIALYSIS PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PHOSPHATE BLOOD LEVEL;

ADULT; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; FEMALE; HUMANS; INDICAN; KIDNEY FAILURE, CHRONIC; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS;

EID: 84867877505     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2012.08.002     Document Type: Article

References (29)

1. Samak M.J., Levey A.S., Schoolwerth A.C., et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association councils on kidney in cardiovascular disease, high blood pressure research, clinical cardiology, and epidemiology and prevention. Circulation 2003, 108:2154-2169.
2. Go A.S., Chertow G.M., Fan D., et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004, 351:1296-1305.
3. Keith D.S., Nichols G.A., Gullion C.M., et al. Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 2004, 164:659-663.
4. Sarnak M.J., Levey A.S. Cardiovascular disease and chronic renal disease: a new paradigm. Am J Kidney Dis Suppl 2000, 35:S117-S131.
5. Culleton B.F., Wilson P.W.F. Cardiovascular disease: risk factors, secular trends and therapeutic guidelines. J Am Soc Nephrol 1998, 9:5-15.
6. Longenecker J.C., Coresh J., Powe N.R., et al. Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE Study. J Am Soc Nephrol 2002, 13:1918-1927.
7. Clarke R., Daly L., Robinson K., et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991, 324:1149-1155.
8. Bammens B., Evenepoel P., Keuleers H., et al. Free serum concentrations of the protein bound retention solute p-cresol predict mortality in hemodialysis patients. Kidney Int 2006, 69:1081-1087.
9. Meijers B.K., Bammens B., De Moor B., et al. Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Kidney Int 2008, 73:1174-1180.
10. Lin C.J., Wu C.J., Pan C.F., et al. Serum protein-bound uraemic toxins and clinical outcomes in haemodialysis patients. Nephrol Dial Transplant 2010, 25:3693-3700.
11. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999, 340:115-126.
12. Wheeler D.C. Cardiovascular disease in patients with chronic renal failure. Lancet 1996, 348:1673-1674.
13. Miyazaki T., Ise M., Hirata M., et al. Indoxyl sulfate stimulates renal synthesis of transforming growth factor-β1 and progression of renal failure. Kidney Int Suppl 1997, 63:S211-S214.
14. Miyazaki T., Ise M., Seo H., et al. Indoxyl sulfate increases the gene expressions of TGF-b1, TIMP-1 and proa1(I) collagen in kidneys of uremic rats. Kidney Int Suppl 1997, 62:S15-S22.
15. Motojima M., Hosokawa A., Yamato H., et al. Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kB and free radical in proximal tubular cells. Kidney Int 2003, 63:1671-1680.
16. Stavrou D. Neovascularisation in wound healing. J Wound Care 2008, 17:298-300. 302.
17. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003, 9:653-660.
18. Yamamoto H., Tsuruoka S., Ioka T., et al. Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells. Kidney Int 2006, 69:1780-1785.
19. Tumur Z., Niwa T. Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells. Am J Nephrol 2009, 29:551-557.
20. Barreto F.C., Barreto D.V., Liabeuf S., et al. Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol 2009, 4:1551-1558.
21. Taki K., Tsuruta Y., Niwa T. Indoxyl sulfate and atherosclerotic risk factors in hemodialysis patients. Am J Nephrol 2007, 27:30-35.
22. Tonelli M., Wiebe N., Culleton B., et al. Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol 2006, 17:2034-2047.
23. Heitzer T., Schlinzig T., Krohn K., et al. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001, 104:2673-2678.
24. Niwa T., Miyazaki T., Hashimoto N., et al. Suppressed serum and urine levels of indoxyl sulfate by oral sorbent in experimental uremic rats. Am J Nephrol 1992, 12:201-206.
25. Lin C.J., Chen H.H., Pan C.F., et al. P-cresylsulfate and indoxyl sulfate level at different stages of chronic kidney disease. J Clin Lab Anal 2011, 25:191-197.
26. Enomoto A., Takeda M., Tojo A., et al. Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. J Am Soc Nephrol 2002, 13:1711-1720.
27. Dou L., Bertrand E., Cerini C., et al. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney Int 2004, 65:442-451.
28. Yu M., Kim Y.J., Kang D.H. Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress. Clin J Am Soc Nephrol 2011, 6:30-39.
29. Lin C.J., Chuang C.K., Liu H.L., et al. The serum levels of P-cresol and indoxyl sulfate in different hemodialysis vintage. J Clin Med Res 2011, 3:114-119.