QT interval and long-term mortality risk in the Framingham heart study

Annals of Noninvasive Electrocardiology

Volumn 17, Issue 4, 2012, Pages 340-348

  Noseworthy, Peter A ^a,b   Peloso, Gina M ^a,c   Hwang, Shih Jen ^c   Larson, Martin G ^c,d,e   Levy, Daniel ^c,f   O'Donnell, Christopher J ^c   Newton Cheh, Christopher ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c FRAMINGHAM HEART STUDY   (United States)

^d Boston University   (United States)

^e BOSTON UNIVERSITY   (United States)

^f NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

heart rate; mortality; QT interval; sudden cardiac death

Indexed keywords

ADULT; ARTICLE; CARDIOVASCULAR RISK; COHORT ANALYSIS; CONFIDENCE INTERVAL; ELECTROCARDIOGRAM; FEMALE; FOLLOW UP; FRAMINGHAM RISK SCORE; HAZARD RATIO; HEART RATE; HUMAN; ISCHEMIC HEART DISEASE; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROGENY; PROPORTIONAL HAZARDS MODEL; QT INTERVAL; RR INTERVAL; SUDDEN DEATH;

ADULT; COHORT STUDIES; CORONARY DISEASE; DEATH, SUDDEN, CARDIAC; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HEART RATE; HUMANS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RISK; RISK FACTORS; UNITED STATES;

EID: 84867870896     PISSN: 1082720X     EISSN: 1542474X     Source Type: Journal    
DOI: 10.1111/j.1542-474X.2012.00535.x     Document Type: Article

References (35)

1. Zheng ZJ, Croft JB, Giles WH, et al., Sudden cardiac death in the United States, 1989 to 1998. Circulation 2001; 104 (18): 2158-2163.
2. Myerburg RJ, Interian A, Jr., Mitrani RM, et al., Frequency of sudden cardiac death and profiles of risk. Am J Cardiol 1997; 80 (5B): 10F-9F.
3. Newton-Cheh C, Larson MG, Corey DC, et al., QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study. Heart Rhythm 2005; 2 (3): 277-284.
4. Akylbekova EL, Crow RS, Johnson WD, et al., Clinical correlates and heritability of QT interval duration in blacks: The Jackson Heart Study. Circ Arrhythmia Electrophysiol 2009; 2: 427-432.
5. Schouten EG, Dekker JM, Meppelink P, et al., QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation 1991; 84 (4): 1516-1523.
6. Straus SM, Kors JA, De Bruin ML, et al., Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 2006; 47 (2): 362-367.
7. Algra A, Tijssen JG, Roelandt JR, et al., QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation 1991; 83 (6): 1888-1894.
8. Dekker JM, Schouten EG, Klootwijk P, et al., Association between QT interval and coronary heart disease in middle-aged and elderly men. The Zutphen Study. Circulation 1994; 90 (2): 779-785.
9. Karjalainen J, Reunanen A, Ristola P, et al., QT interval as a cardiac risk factor in a middle aged population. Heart 1997; 77 (6): 543-548.
10. Elming H, Holm E, Jun L, et al., The prognostic value of the QT interval and QT interval dispersion in all-cause and cardiac mortality and morbidity in a population of Danish citizens. Eur Heart J 1998; 19 (9): 1391-400.
11. Crow RS, Hannan PJ, Folsom AR,. Prognostic significance of corrected QT and corrected JT interval for incident coronary heart disease in a general population sample stratified by presence or absence of wide QRS complex: The ARIC Study with 13 years of follow-up. Circulation 2003; 108 (16): 1985-1989.
12. Dekker JM, Crow RS, Hannan PJ, et al., Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: The ARIC study. J Am Coll Cardiol 2004; 43 (4): 565-571.
13. Robbins J, Nelson JC, Rautaharju PM, et al., The association between the length of the QT interval and mortality in the Cardiovascular Health Study. Am J Med 2003; 115 (9): 689-694.
14. Goldberg RJ, Bengtson J, Chen ZY, et al., Duration of the QT interval and total and cardiovascular mortality in healthy persons (The Framingham Heart Study experience). Am J Cardiol 1991; 67 (1): 55-58.
15. Dawber TR, Kannel WB, Lyell LP,. An approach to longitudinal studies in a community: The Framingham Study. Ann N Y Acad Sci 1963; 107: 539-556.
16. Dawber TR, Meadors GF, Moore FE, Jr., Epidemiological approaches to heart disease: The Framingham Study. Am J Public Health Nations Health 1951; 41 (3): 279-281.
17. Feinleib M, Kannel WB, Garrison RJ, et al., The Framingham offspring study. Design and preliminary data. Prev Med 1975; 4 (4): 518-525.
18. Sagie A, Larson MG, Goldberg RJ, et al., An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study). Am J Cardiol 1992; 70 (7): 797-801.
19. Larson MG, Atwood LD, Benjamin EJ, et al., Framingham Heart Study 100K project: Genome-wide associations for cardiovascular disease outcomes. BMC Med Genet 2007; 8 (Suppl 1): S5.
20. Fox CS, Evans JC, Larson MG, et al., A comparison of death certificate out-of-hospital coronary heart disease death with physician-adjudicated sudden cardiac death. Am J Cardiol 2005; 95 (7): 856-859.
21. Terry Therneau and original Splus->R port by Thomas Lumley (2011). Survival: Survival analysis including penalised likelihood. R package version 2.36-5. http://CRAN.R-project.org/package=survival.
22. Committee for Proprietary Medicinal Products (CPMP). Points to consider: the assessment of the potential for QT interval prolongation by non-cardiovascular medicinal products. European Agency for the Evaluation of Medicinal Products, London, UK, 1997.
23. Products CfPM. The assessment of the potential for QT interval prolongation by non-cardiovascular medicinal products. Committee for Proprietary Medicinal Products; 1997.
24. de Bruyne MC, Hoes AW, Kors JA, et al., Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study. Eur Heart J 1999; 20 (4): 278-284.
25. Chugh SS, Reinier K, Singh T, et al., Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: The Oregon Sudden Unexpected Death Study. Circulation 2009; 119 (5): 663-670.
26. Montanez A, Ruskin JN, Hebert PR, et al., Prolonged QTc interval and risks of total and cardiovascular mortality and sudden death in the general population: A review and qualitative overview of the prospective cohort studies. Arch Intern Med 2004; 164 (9): 943-948.
27. Zhang Y, Post WS, Dalal D, et al., QT-interval duration and mortality rate: Results from the Third National Health and Nutrition Examination Survey. Arch Intern Med 171 (19): 1727-1733.
28. Newton-Cheh C, Eijgelsheim M, Rice KM, et al., Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet 2009; 41 (4): 399-406.
29. Pfeufer A, Sanna S, Arking DE, et al., Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet 2009; 41 (4): 407-414.
30. Akhras F, Rickards AF,. The relationship between QT interval and heart rate during physiological exercise and pacing. Jpn Heart J 1981; 22 (3): 345-351.
31. Jouven X, Empana JP, Escolano S, et al., Relation of heart rate at rest and long-term (>20 years) death rate in initially healthy middle-aged men. Am J Cardiol 2009; 103 (2): 279-283.
32. Jouven X, Zureik M, Desnos M, et al., Resting heart rate as a predictive risk factor for sudden death in middle-aged men. Cardiovasc Res 2001; 50 (2): 373-378.
33. Russell MW, Law I, Sholinsky P, et al., Heritability of ECG measurements in adult male twins. J Electrocardiol 1998; 30 (Suppl): 64-68.
34. Dalageorgou C, Ge D, Jamshidi Y, et al., Heritability of QT interval: How much is explained by genes for resting heart rate? J Cardiovasc Electrophysiol 2008; 19 (4): 386-391.
35. Rautaharju PM, Surawicz B, Gettes LS, et al., AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: Part IV: The ST segment, T and U waves, and the QT interval: A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: Endorsed by the International Society for Computerized Electrocardiology. Circulation 2009; 119 (10): e241-e250.