Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea

Planta Medica

Volumn 78, Issue 15, 2012, Pages 1661-1666

  Wang, Nan ^a   Li, Zhan Lin ^a   Song, Dan Dan ^a   Li, Wei ^b   Pei, Yue Hu ^a   Jing, Yong Kui ^c   Hua, Hui Ming ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b TOHO UNIVERSITY   (Japan)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

antiproliferative activity; Kadsura coccinea; leukemia HL 60; Schizandraceae; triterpenoid

Indexed keywords

3,4 SECO LANOSTANE; ANTINEOPLASTIC AGENT; FLUOROURACIL; SECO COCCINIC ACID; TRITERPENOID; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CELL GROWTH; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; KADSURA; KADSURA COCCINEA; LEUKEMIA CELL; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; DRUGS, CHINESE HERBAL; HL-60 CELLS; HUMANS; KADSURA; LANOSTEROL; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PLANT ROOTS; PLANTS, MEDICINAL; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRITERPENES;

KADSURA COCCINEA;

EID: 84867863526     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1315260     Document Type: Article

References (18)

1. Song L. R., Hong X., Ding X. L., Zang Z. Y. Dictionary of modern science of Chinese materia medica, Volume 2. Beijing Peoples Health Publishing House: 2001; 2172 2173
2. Jiangsu New Medical College Dictionary of traditional Chinese medicine. Shanghai Shanghai Science and Technology Publishing House: 1999; 3330 3331
3. Li L. N., Xue H., Tan R. Dibenzocyclooctadiene lignans from roots and stems of Kadsura coccinea. Planta Med: 1985; 51 297 300 (Pubitemid 15014324)
4. Liu J. S., Li L. Schisantherins L-O and acetylschisantherin L from Kadsura coccinea. Phytochemistry: 1993; 32 1293 1296
5. Liu J. S., Li L. Kadsulignans L-N, three dibenzocyclooctadiene lignans from Kadsura coccinea. Phytochemistry: 1995; 38 241 245
6. Li H. R., Feng Y. L., Yang Z. G., Wang J., Daikonya A., Kitanaka S., Xu L. Z., Yang S. L. New lignans from Kadsura coccinea and their nitric oxide inhibitory activities. Chem Pharm Bull: 2006; 54 1022 1025
7. Li H. R., Wang L. Y., Yang Z. G., Kitanaka S. Kadsuralignans H-K from Kadsura coccinea and their nitric oxide production inhibitory effects. J Nat Prod: 2007; 70 1999 2002
8. Li L. N., Xue H. Triterpenoids from roots and stems of Kadsura coccinea. Planta Med: 1986; 52 492 493 (Pubitemid 17226400)
9. Gao X. M., Pu J. X., Huang S. X., Lu Y., Luo L. G., Li R. T., Xiao W. L., Chang Y., Sun H. D. Kadcoccilactones A-J, triterpenoids from Kadsura coccinea. J Nat Prod: 2008; 71 1182 1188
10. Gao X. M., Pu J. X., Xiao W. L., Huang S. X., Lou L. G., Sun H. D. Kadcoccilactones K-R, triterpenoids from Kadsura coccinea. Tetrahedron: 2008; 64 11673 11679
11. Li H. R., Wang L. Y., Miyata S., Kitanaka S. Kasuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis. J Nat Prod: 2008; 71 739 741 (Pubitemid 351656220)
12. Sy L. K., Brown G. D. Novel seco-cycloartanes from Kadsura coccinea and the assisted autoxidation of a tri-substituted alkene. Tetrahedron: 1999; 55 119 132 (Pubitemid 29005271)
13. Wang N., Li Z. L., Song D. D., Li W., Fu H. W., Koike K., Pei Y. H., Jing Y. K. Lanostane-type triterpenoids from the roots of Kadsura coccinea. J Nat Prod: 2008; 71 990 994 (Pubitemid 352013499)
14. Wang N., Li Z. L., Li D. Y., Pei Y. H., Hua H. M. Five new triterpenoids from the roots of Kadsura coccinea. Helv Chim Acta: 2009; 92 1413 1418
15. Ban N. K., Thanh B. V., Kiem P. V., Minh C. V., Cuong N. X., Nhiem N. X., Huong H. T., Anh H. T., Park E. J., Sohn D. H., Kim Y. H. Dibenzocyclooctadiene lignans and lanostane derivatives from the roots of Kadsura coccinea and their protective effects on primary rat hepatocyte injury induced by t -butyl hydroperoxide. Planta Med: 2009; 75 1253 1257
16. Wang F., Hua H. M., Pei Y. H., Chen D., Jing Y. K. Triterpenoids from the resin of Styrax tonkinensis and their antiproliferative and differentiation effects in human leukemia HL-60 cells. J Nat Prod: 2006; 69 807 810 (Pubitemid 44021410)
17. Liu J. S., Huang M. F., Tao Y. Anwuweizonic acid and manwuweizic acid, the putative anticancer active principle of Schisandra propinqua. Can J Chem: 1988; 66 414 415
18. Arjun H. B., Yasuhiro T., Kim Q. T., Ken T., Ikuo S., Shigetoshi K. Thirteen novel cycloartane-type triterpenes from Combretum guadrangulare. J Nat Prod: 2000; 63 57 64