Contribution of the oatp1b subfamily to cancer biology and treatment

Clinical Pharmacology and Therapeutics

Volumn 92, Issue 5, 2012, Pages 658-660

  Sissung, T M ^a   Reece, K M ^a   Spencer, S ^a   Figg, W D ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABIRATERONE; CABAZITAXEL; ENZALUTAMIDE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1B; OXALIPLATIN; TESTOSTERONE; UNCLASSIFIED DRUG;

CANCER RESISTANCE; CANCER THERAPY; HOMEOSTASIS; HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; REVIEW;

GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER; NEOPLASMS; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT;

EID: 84867857794     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2012.127     Document Type: Review

References (5)

1. Obaidat, A., Roth, M. & Hagenbuch, B. The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Annu. Rev. Pharmacol. Toxicol. 52, 135-151 (2012).
2. Hamada, A. et al. Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer. Clin. Cancer Res. 14, 3312-3318 (2008).
3. Nagai, M. et al. Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells. Biochem. Biophys. Res. Commun. 418, 818-823 (2012).
4. Giorgi, E.P. Studies on androgen transport into canine prostate in vitro. J. Endocrinol. 68, 109-119 (1976).
5. van de Steeg, E. et al. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J. Clin. Invest. 122, 519-528 (2012).